Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Ghassan Bkaily, Yanick Simon, Ashley Jazzar, Houssein Najibeddine, Alexandre Normand, Danielle Jacques
Summary: Our understanding of essential hypertension is extensive, and while its treatment is well-known, not all individuals with hypertension are salt-sensitive. Even normotensive individuals may face increased cardiovascular risks with a high salt diet. Research on the mechanisms and treatment of hypertension sensitive to high-sodium diets is crucial.
Article
Medicine, Research & Experimental
Slaven Crnkovic, Francesco Valzano, Elisabeth Fliesser, Juergen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Joerg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna Kwapiszewska
Summary: This study utilized single-cell RNA sequencing to reveal cellular composition changes in pulmonary arterial hypertension and donor lungs. The results showed that remodeling altered communication between immune and structural cells, especially smooth muscle cells. Different populations of smooth muscle cells were enriched in specific biological processes and associated with the development of vascular remodeling.
Article
Biochemistry & Molecular Biology
Xiaowei Nie, Chenyou Shen, Jianxin Tan, Xusheng Yang, Wei Wang, Youai Dai, Haijian Sun, Zhiyuan Wu, Jingyu Chen
Summary: The study demonstrated that Andrographolide (ANDRO) may reverse pulmonary vascular remodeling through modulation of NOX/Nrf2-mediated oxidative stress and NF-kappa B-mediated inflammation, suggesting therapeutic potential in the treatment of pulmonary hypertension.
Review
Pharmacology & Pharmacy
Guang-Xuan Zhu, Jian-Li Zuo, Lin Xu, Shu-Qing Li
Summary: Abnormal vascular remodeling (VR) precedes many cardiovascular diseases, highlighting the potential of ginsenoside as a pivotal target for treatment and prevention. Research suggests that ginsenosides can improve VR caused by vasodilation dysfunction, abnormal structure, and blood pressure.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Carmen Gutierrez-Munoz, Luis Miguel Blanco-Colio
Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Lei Wang, Megan Rice, Sandra Swist, Thomas Kubin, Fan Wu, Shengpeng Wang, Simone Kraut, Norbert Weissmann, Thomas Boettger, Matthew Wheeler, Andre Schneider, Thomas Braun
Summary: The study revealed that BMP9 and BMP10 act directly on VSMCs for induction and maintenance of their contractile state. The effects of BMP9/10 in VSMCs are mediated by different combinations of BMP type 1 receptors in a vessel bed-specific manner, offering new opportunities to manipulate blood pressure in the pulmonary circulation.
Article
Chemistry, Multidisciplinary
Chao Ye, Ying Tong, Nan Wu, Guo-wei Wan, Fen Zheng, Jing-yu Chen, Jian-zhen Lei, Hong Zhou, Ai-dong Chen, Jue-jin Wang, Qi Chen, Yue-hua Li, Yu-ming Kang, Guo-qing Zhu
Summary: The study demonstrated that miR-135a-5p promotes vascular smooth muscle cell (VSMC) proliferation in spontaneously hypertensive rats (SHRs), while FNDC5 inhibits it. Silencing miR-135a-5p or upregulating FNDC5 could attenuate VSMC proliferation and vascular remodeling in SHRs. These findings suggest that manipulating miR-135a-5p or FNDC5 levels may be a therapeutic strategy for reducing vascular remodeling and hypertension.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Materials Science, Biomaterials
Uxue Aizarna-Lopetegui, Clara Garcia-Astrain, Carlos Renero-Lecuna, Patricia Gonzalez-Callejo, Irune Villaluenga, Miguel A. del Pozo, Miguel Sanchez-Alvarez, Malou Henriksen-Lacey, Dorleta Jimenez de Aberasturi
Summary: This study presents a method for creating a dynamic artery model using 3D printing and thermoresponsive polymers that mimic arterial pulsation. The expansion and contraction of the polymers through plasmonic nanoparticles activate mechanotransduction gene pathways, as demonstrated by transcriptional changes.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Charifa Awada, Alice Bourgeois, Sarah-Eve Lemay, Yann Grobs, Tetsuro Yokokawa, Sandra Breuils-Bonnet, Sandra Martineau, Vinod Krishna, Francois Potus, Jey Jeyaseelan, Steeve Provencher, Sebastien Bonnet, Olivier Boucherat
Summary: Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling, and the inhibition of the histone methyltransferase G9a/GLP may represent a new therapeutic approach for PAH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Critical Care Medicine
Geraldine Vitry, Roxane Paulin, Yann Grobs, Marie-Claude Lampron, Tsukasa Shimauchi, Sarah-Eve Lemay, Eve Tremblay, Karima Habbout, Charifa Awada, Alice Bourgeois, Valerie Nadeau, Renee Paradis, Sandra Breuils-Bonnet, Florence Roux-Dalvai, Mark Orcholski, Francois Potus, Steeve Provencher, Olivier Boucherat, Sebastien Bonnet
Summary: The study identified an increased expression of detoxifying DNA enzyme NUDT1 in patients with pulmonary arterial hypertension (PAH) and animal models, with its inhibition leading to improvements in DNA damage, cell death, and vascular remodeling, as well as hemodynamics and cardiac function in animal models of PAH. These findings suggest that NUDT1 inhibitors may represent a new therapeutic option for PAH patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nan Wu, Fen Zheng, Na Li, Ying Han, Xiao-Qing Xiong, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ye-Bo Zhou
Summary: The study revealed that RND3 plays critical roles in attenuating superoxide production, vascular smooth muscle cells migration and proliferation, and vascular remodeling in hypertension by inhibiting ROCK1-NOX1/2 and mitochondria superoxide signaling.
Article
Cardiac & Cardiovascular Systems
Joseph M. Miano, Edward A. Fisher, Mark W. Majesky
Summary: Studying the phenotypic modulation of vascular smooth muscle cells is crucial for understanding the pathogenesis of atherosclerosis and developing new therapies. Recent technological and conceptual advances shed light on the multifunctionality and plasticity of VSMCs.
Article
Biochemistry & Molecular Biology
Sayeman Islam Niloy, Yue Shen, Lirong Guo, Stephen T. O'Rourke, Chengwen Sun
Summary: This study reveals that dysfunction of BKCa channels in vascular smooth muscle cells (VSMCs) is related to abnormal proliferation and morphological changes in hypertension, possibly due to decoupling of IP3R-BKCa. Genetic disruption of IP3R-BKCa coupling increases VSMC proliferation, while infusion of the BKCa opener NS1619 attenuates vascular hypertrophy in hypertensive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)