Omega-3 Fatty Acids and Skeletal Muscle Health

Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice

(2015) Matthew L. Johnson et al.   AGING CELL

Fish oil–derived n−3 PUFA therapy increases muscle mass and function in healthy older adults1

(2015) Gordon I Smith et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

(2015) Philip C. Calder   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans

(2015) Antigoni Z. Lalia et al.   DIABETES CARE

Bioactive products formed in humans from fish oils

(2015) Carsten Skarke et al.   JOURNAL OF LIPID RESEARCH

DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation

(2015) Frédéric Capel et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Age-related neuromuscular changes affecting human vastus lateralis

(2015) M. Piasecki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Both linoleic and α-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats

(2014) Sarthak Matravadia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation

(2014) Francis B. Stephens et al.   CLINICAL SCIENCE

Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle

(2014) E. A. F. Herbst et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal changes in human skeletal muscle and blood lipid composition with fish oil supplementation

(2014) Chris McGlory et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-aged overweight men

(2014) Benjamin B. Albert et al.   Scientific Reports

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet

(2013) Ian R. Lanza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes

(2013) Torkamol Kamolrat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elevated tissue omega-3 fatty acid status prevents age-related glucose intolerance in fat-1 transgenic mice

(2013) Talita Romanatto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Disuse-induced muscle wasting

(2013) Sue C. Bodine   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effects of Age, Sex, Body Mass Index and APOE Genotype on Cardiovascular Biomarker Response to an n-3 Polyunsaturated Fatty Acid Supplementation

(2013) Elisabeth Thifault et al.   Journal of Nutrigenetics and Nutrigenomics

n3 PUFAs Do Not Affect Adipose Tissue Inflammation in Overweight to Moderately Obese Men and Women

(2013) Mario Kratz et al.   JOURNAL OF NUTRITION

Estimation of Total Body Skeletal Muscle Mass in Chinese Adults: Prediction Model by Dual-Energy X-Ray Absorptiometry

(2013) Xinyu Zhao et al.   PLoS One

Individual Variation in Lipidomic Profiles of Healthy Subjects in Response to Omega-3 Fatty Acids

(2013) Malin L. Nording et al.   PLoS One

Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation

(2013) Elizabeth Barber et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Obesity in young men, and individual and combined risks of type 2 diabetes, cardiovascular morbidity and death before 55 years of age: a Danish 33-year follow-up study

(2013) Morten Schmidt et al.   BMJ Open

DHA Inhibits Protein Degradation More Efficiently than EPA by Regulating the PPARγ/NFκB Pathway in C2C12 Myotubes

(2013) Yue Wang et al.   Biomed Research International

Fish-oil supplementation enhances the effects of strength training in elderly women

(2012) Cintia LN Rodacki et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Long-chain n−3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial

(2012) Bianca K Itariu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Docosahexaenoic and Eicosapentaenoic Acids Segregate Differently between Raft and Nonraft Domains

(2012) Justin A. Williams et al.   BIOPHYSICAL JOURNAL

Fish oil supplementation augments post-exercise immune function in young males

(2012) Patrick Gray et al.   BRAIN BEHAVIOR AND IMMUNITY

Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis

(2012) Jason H. Y. Wu et al.   BRITISH JOURNAL OF NUTRITION

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

(2012) Nicolas J Pillon et al.   Cell Communication and Signaling

Resolvins D1, D2, and Other Mediators of Self-Limited Resolution of Inflammation in Human Blood following n-3 Fatty Acid Supplementation

(2012) E. Mas et al.   CLINICAL CHEMISTRY

Fish consumption, omega-3 fatty acids and risk of heart failure: A meta-analysis

(2012) Luc Djoussé et al.   CLINICAL NUTRITION

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

(2012) M. Bosma et al.   DIABETES

Fish oil positively regulates anabolic signalling alongside an increase in whole-body gluconeogenesis in ageing skeletal muscle

(2012) Torkamol Kamolrat et al.   EUROPEAN JOURNAL OF NUTRITION

Association Between Omega-3 Fatty Acid Supplementation and Risk of Major Cardiovascular Disease Events

(2012) Evangelos C. Rizos et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes

(2012) F. H. J. van Tienen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

n-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-κB-dependent mechanisms

(2012) Nalin Siriwardhana et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation

(2012) Peter Magee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells

(2012) Roger A Vaughan et al.   Lipids in Health and Disease

Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health

(2012) Celia G. Walker et al.   NUTRITION

Metabolic Effects of n-3 PUFA as Phospholipids Are Superior to Triglycerides in Mice Fed a High-Fat Diet: Possible Role of Endocannabinoids

(2012) Martin Rossmeisl et al.   PLoS One

Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling

(2012) P. C. Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century

(2011) Tanya L Blasbalg et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs

(2011) W. Smink et al.   Animal

Omega-3: A link between global climate change and human health

(2011) Jing X. Kang   BIOTECHNOLOGY ADVANCES

Omega-3 polyunsaturated fatty acid and insulin sensitivity: A meta-analysis of randomized controlled trials

(2011) Akintunde O. Akinkuolie et al.   CLINICAL NUTRITION

Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia–hyperaminoacidaemia in healthy young and middle-aged men and women

(2011) Gordon I. Smith et al.   CLINICAL SCIENCE

Sarcopenia: Origins and Clinical Relevance

(2011) Irwin H. Rosenberg   CLINICS IN GERIATRIC MEDICINE

Regulation of muscle protein synthesis in humans

(2011) Bethan E. Phillips et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men

(2011) I Reinders et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

(2011) Leslie M. Baehr et al.   JOURNAL OF PHYSIOLOGY-LONDON

Elongase Reactions as Control Points in Long-Chain Polyunsaturated Fatty Acid Synthesis

(2011) Melissa K. Gregory et al.   PLoS One

Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial

(2010) Gordon I Smith et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cellular depletion of atypical PKCλ is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells

(2010) Clare Stretton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved glucose tolerance

(2010) Brennan K. Smith et al.   Applied Physiology Nutrition and Metabolism

Dietary fish oil alleviates soleus atrophy during immobilization in association with Akt signaling to p70s6k and E3 ubiquitin ligases in rats

(2010) Jae-Sung You et al.   Applied Physiology Nutrition and Metabolism

Specialized pro-resolving lipid mediators in the inflammatory response: An update

(2010) Gerard Bannenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

EPA inhibits the inhibitor of κBα (IκBα)/NF-κB/muscle RING finger 1 pathway in C2C12 myotubes in a PPARγ-dependent manner

(2010) Feiruo Huang et al.   BRITISH JOURNAL OF NUTRITION

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

AMP-activated Protein Kinase  2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

(2010) T. Jelenik et al.   DIABETES

Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat-Fed Mice

(2010) P. J. White et al.   DIABETES

Metabolic switching of human myotubes is improved by n-3 fatty acids

(2010) N. P. Hessvik et al.   JOURNAL OF LIPID RESEARCH

Effects of Eicosapentaenoic Acid (EPA) Treatment on Insulin Sensitivity in an Animal Model of Diabetes: Improvement of the Inflammatory Status

(2010) Maite Figueras et al.   Obesity

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Docosapentaenoic acid (22:5n-3): A review of its biological effects

(2010) Gunveen Kaur et al.   PROGRESS IN LIPID RESEARCH

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Omega-3 Fatty Acids and Inflammatory Processes

(2010) Philip C. Calder   Nutrients

Enteral Nutrition Enriched With Eicosapentaenoic Acid (EPA) Preserves Lean Body Mass Following Esophageal Cancer Surgery: Results of a Double-Blinded Randomized Controlled Trial

(2009) Aoife M. Ryan et al.   ANNALS OF SURGERY

Omega-3 Dietary Supplements and the Risk of Cardiovascular Events: A Systematic Review

(2009) Paul E. Marik et al.   CLINICAL CARDIOLOGY

Cellular Production of n-3 PUFAs and Reduction of n-6-to-n-3 Ratios in the Pancreatic  -Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death

(2009) D. Wei et al.   DIABETES

Functional Modulation of Mitochondria by Eicosapentaenoic Acid Provides Protection against Ceramide Toxicity to C6 Glioma Cells

(2009) Jaan-Yeh Jeng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling

(2009) Micah J. Drummond et al.   JOURNAL OF APPLIED PHYSIOLOGY

Towards Establishing Dietary Reference Intakes for Eicosapentaenoic and Docosahexaenoic Acids

(2009) William S. Harris et al.   JOURNAL OF NUTRITION

Docosahexaenoic Acid Modifies the Clustering and Size of Lipid Rafts and the Lateral Organization and Surface Expression of MHC Class I of EL4 Cells

(2009) Saame Raza Shaikh et al.   JOURNAL OF NUTRITION

Dietary fish oil inhibits the early stage of recovery of atrophied soleus muscle in rats via Akt–p70s6k signaling and PGF2α

(2009) Jae-Sung You et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Omega-3 Polyunsaturated Fatty Acids Down-Modulate CXCR4 Expression and Function in MDA-MB-231 Breast Cancer Cells

(2009) J. D. Altenburg et al.   MOLECULAR CANCER RESEARCH

Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of  -Oxidation Products Because of Impaired Fatty Acid Oxidation: Effects of Tetradecylthioacetic Acid and Eicosapentaenoic Acid

(2008) A. J. Wensaas et al.   DIABETES

Increased Daily Walking Improves Lipid Oxidation Without Changes in Mitochondrial Function in Type 2 Diabetes

(2008) M. I. Trenell et al.   DIABETES CARE

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear factor-kappa B signaling in skeletal muscle atrophy

(2008) Hong Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation

(2008) Peter Magee et al.   Lipids in Health and Disease

Impaired Skeletal Muscle Substrate Oxidation in Glucose-intolerant Men Improves After Weight Loss

(2008) Eva Corpeleijn et al.   Obesity

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

(2008) C. R. Hancock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The acute effects of differential dietary fatty acids on human skeletal muscle pyruvate dehydrogenase activity

(2007) Nicolette S. Bradley et al.   JOURNAL OF APPLIED PHYSIOLOGY