TP53 Mutants in the Tower of Babel of Cancer Progression

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

Mutant TP53 Posttranslational Modifications: Challenges and Opportunities

(2014) Thuy-Ai Nguyen et al.   HUMAN MUTATION

Locus-Specific Databases in Cancer: What Future in a Post-Genomic Era? The TP53 LSDB paradigm

(2014) Thierry Soussi   HUMAN MUTATION

Insights into Wild-Type and Mutant p53 Functions Provided by Genetically Engineered Mice

(2014) Lawrence A. Donehower   HUMAN MUTATION

Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

(2013) Jerson L. Silva et al.   BIOSCIENCE REPORTS

Li Fraumeni syndrome, cancer and senescence: a new hypothesis

(2013) Pan Pantziarka   Cancer Cell International

Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

(2013) W Hanel et al.   CELL DEATH AND DIFFERENTIATION

XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling

(2013) Xing Huang et al.   EMBO JOURNAL

Does TP53 mutation promote ovarian cancer metastasis to omentum by regulating lipid metabolism?

(2013) Jing Hu et al.   MEDICAL HYPOTHESES

Increased Oxidative Metabolism in the Li–Fraumeni Syndrome

(2013) Ping-Yuan Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

(2013) Daniel Menendez et al.   NUCLEIC ACIDS RESEARCH

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code

(2013) Y. Ciribilli et al.   NUCLEIC ACIDS RESEARCH

Small molecule induced reactivation of mutant p53 in cancer cells

(2013) Xiangrui Liu et al.   NUCLEIC ACIDS RESEARCH

Preferential Binding of Hot Spot Mutant p53 Proteins to Supercoiled DNA In Vitro and in Cells

(2013) Marie Brázdová et al.   PLoS One

Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta

(2013) Shalom Madar et al.   PLoS One

Expression of Galectin-7 Is Induced in Breast Cancer Cells by Mutant p53

(2013) Carole G. Campion et al.   PLoS One

Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression

(2013) W Wang et al.   Cell Death & Disease

p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

(2013) Bei Wang et al.   Nature Communications

More targets, more pathways and more clues for mutant p53

(2013) S Garritano et al.   Oncogenesis

Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment

(2013) G S Wong et al.   Oncogenesis

The rebel angel: mutant p53 as the driving oncogene in breast cancer

(2012) D. Walerych et al.   CARCINOGENESIS

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop

(2012) Fabio Valenti et al.   CELL CYCLE

Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity

(2012) Timo Quante et al.   CELL CYCLE

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

(2012) Cynthia R Coffill et al.   EMBO REPORTS

Mutant p53 cooperates with ETS2 to promote etoposide resistance

(2012) P. M. Do et al.   GENES & DEVELOPMENT

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Drastic Effect of GermlineTP53Missense Mutations in Li-Fraumeni Patients

(2012) Yasmine Zerdoumi et al.   HUMAN MUTATION

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

(2012) Hilla Solomon et al.   JOURNAL OF CELL SCIENCE

Mutant p53R273Hattenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

(2012) Eyal Kalo et al.   JOURNAL OF CELL SCIENCE

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis

(2012) Bernard Leroy et al.   NUCLEIC ACIDS RESEARCH

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

Mutant p53 drives invasion in breast tumors through up-regulation of miR-155

(2012) P M Neilsen et al.   ONCOGENE

Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

(2012) P Dong et al.   ONCOGENE

Increased Oxidative Damage in Carriers of the Germline TP53 p.R337H Mutation

(2012) Gabriel S. Macedo et al.   PLoS One

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

(2012) A. S. Ethayathulla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence-dependent sliding kinetics of p53

(2012) J. S. Leith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs, wild-type and mutant p53: More questions than answers

(2012) Matthew Fletcher Jones et al.   RNA Biology

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration

(2011) W.Andrew Yeudall et al.   CARCINOGENESIS

Phospho-ΔNp63α is a key regulator of the cisplatin-induced microRNAome in cancer cells

(2011) Y Huang et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

(2011) S Donzelli et al.   CELL DEATH AND DIFFERENTIATION

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

p53, a novel regulator of lipid metabolism pathways

(2011) Ido Goldstein et al.   JOURNAL OF HEPATOLOGY

TopBP1 Mediates Mutant p53 Gain of Function through NF-Y and p63/p73

(2011) K. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Dominant-Negative Features of Mutant TP53 in Germline Carriers Have Limited Impact on Cancer Outcomes

(2011) P. Monti et al.   MOLECULAR CANCER RESEARCH

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription

(2011) Emily C. Knouf et al.   NUCLEIC ACIDS RESEARCH

Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11

(2011) J E Noll et al.   ONCOGENE

Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

(2010) Perry Stambolsky et al.   CANCER CELL

Transcription Factor NF-Y Induces Apoptosis in Cells Expressing Wild-Type p53 through E2F1 Upregulation and p53 Activation

(2010) A. Gurtner et al.   CANCER RESEARCH

Id2gene is a transcriptional target of the protein complex mutant p53/E2F1

(2010) Giulia Fontemaggi et al.   CELL CYCLE

Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells

(2010) I Kogan-Sakin et al.   CELL DEATH AND DIFFERENTIATION

Characterization of Functional Domains Necessary for Mutant p53 Gain of Function

(2010) Wensheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway

(2010) Ricardo E. Perez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

(2010) Jennifer J. Jordan et al.   MOLECULAR CANCER RESEARCH

DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

(2010) Katharina Schlereth et al.   MOLECULAR CELL

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

(2010) Malka Kitayner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cross talk between stimulated NF-κB and the tumor suppressor p53

(2010) G Schneider et al.   ONCOGENE

The Coordinated P53 and Estrogen Receptor Cis-Regulation at an FLT1 Promoter SNP Is Specific to Genotoxic Stress and Estrogenic Compound

(2010) Yari Ciribilli et al.   PLoS One

Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences

(2010) D. Menendez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Research: The Past Thirty Years and the Next Thirty Years

(2010) D. Lane et al.   Cold Spring Harbor Perspectives in Biology

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

(2009) S. Haupt et al.   CANCER RESEARCH

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

(2009) Giulia Fontemaggi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A common gain of function of p53 cancer mutants in inducing genetic instability

(2009) D P Liu et al.   ONCOGENE

Ultraslow oligomerization equilibria of p53 and its implications

(2009) E. Natan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

(2009) A. C. Joerger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

Mouse Models of p53 Functions

(2009) G. Lozano   Cold Spring Harbor Perspectives in Biology

Clinical Outcomes and Correlates of TP53 Mutations and Cancer

(2009) A. I. Robles et al.   Cold Spring Harbor Perspectives in Biology

Presence of dominant negative mutation of TP53 is a risk of early recurrence in oral cancer

(2008) Nur Mohammad Monsur Hassan et al.   CANCER LETTERS

PTEN Has Tumor-Promoting Properties in the Setting of Gain-of-Function p53 Mutations

(2008) Y. Li et al.   CANCER RESEARCH

Suppression of Inhibitor of Differentiation 2, a Target of Mutant p53, Is Required for Gain-of-Function Mutations

(2008) W. Yan et al.   CANCER RESEARCH

Oncogenomic Approaches in Exploring Gain of Function of Mutant p53

(2008) Sara Donzelli et al.   CURRENT GENOMICS

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome

(2008) A. Shlien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

(2008) Jennifer J. Jordan et al.   PLoS Genetics