More targets, more pathways and more clues for mutant p53

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

Different Mutant/Wild-Type p53 Combinations Cause a Spectrum of Increased Invasive Potential in Nonmalignant Immortalized Human Mammary Epithelial Cells

(2015) Damian J. Junk et al.   NEOPLASIA

Metabolic changes in cancer: beyond the Warburg effect

(2012) W. Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Allele specific gain-of-function activity of p53 mutants in lung cancer cells

(2012) Catherine A. Vaughan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proline dehydrogenase (oxidase) in cancer

(2012) Wei Liu et al.   BIOFACTORS

The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer

(2012) Anders Christiansen et al.   CANCER LETTERS

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis

(2012) Bernard Leroy et al.   NUCLEIC ACIDS RESEARCH

Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

(2012) P Dong et al.   ONCOGENE

Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice

(2012) Deepak Kanojia et al.   PROTEOMICS

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity

(2011) Catherine A. Vaughan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Heavy Chain Ferritin siRNA Delivered by Cationic Liposomes Increases Sensitivity of Cancer Cells to Chemotherapeutic Agents

(2011) X. Liu et al.   CANCER RESEARCH

The p53 response element and transcriptional repression

(2011) Bei Wang et al.   CELL CYCLE

Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop

(2011) G Blandino et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

(2011) S Donzelli et al.   CELL DEATH AND DIFFERENTIATION

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

One Function—Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor

(2011) Levin Böhlig et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

p53, a novel regulator of lipid metabolism pathways

(2011) Ido Goldstein et al.   JOURNAL OF HEPATOLOGY

Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras

(2011) Sergio Acin et al.   JOURNAL OF PATHOLOGY

Mutant p53 gain of function is interwoven into the hallmarks of cancer

(2011) Hilla Solomon et al.   JOURNAL OF PATHOLOGY

Wild-type p53 controls cell motility and invasion by dual regulation of MET expression

(2011) C.-I. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

To repress or not to repress: This is the guardian's question

(2011) John L. Rinn et al.   TRENDS IN CELL BIOLOGY

Reciprocal influence of the p53 and the hypoxic pathways

(2011) A Sermeus et al.   Cell Death & Disease

COMPASSS (COMplex PAttern of Sequence Search Software), a simple and effective tool for mining complex motifs in whole genomes

(2010) Giuseppe Maccari et al.   BIOINFORMATICS

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy

(2010) Gianluca Bossi et al.   CELL CYCLE

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function

(2010) Aymone Gurtner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Research: The Past Thirty Years and the Next Thirty Years

(2010) D. Lane et al.   Cold Spring Harbor Perspectives in Biology

Targeting p53 for enhanced radio- and chemo-sensitivity

(2009) Chao Lu et al.   APOPTOSIS

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

(2009) Maria A. Lebedeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?

(2009) Maria Isabel Waddington Achatz et al.   LANCET ONCOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

A common gain of function of p53 cancer mutants in inducing genetic instability

(2009) D P Liu et al.   ONCOGENE

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Activated p53 induces NF-κB DNA binding but suppresses its transcriptional activation

(2008) Keiko Kawauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncogenomic Approaches in Exploring Gain of Function of Mutant p53

(2008) Sara Donzelli et al.   CURRENT GENOMICS

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Par complex in cancer: a regulator of normal cell polarity joins the dark side

(2008) V Aranda et al.   ONCOGENE

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

(2008) Jennifer J. Jordan et al.   PLoS Genetics