Mutant TP53 Posttranslational Modifications: Challenges and Opportunities

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

(2016) Nicola J. Maclaine et al.   Aging-US

Lysine methylation and the regulation of p53

(2014) Simon M. Carr et al.   Essays in Biochemistry

Insights into Wild-Type and Mutant p53 Functions Provided by Genetically Engineered Mice

(2014) Lawrence A. Donehower   HUMAN MUTATION

Readout of Epigenetic Modifications

(2013) Dinshaw J. Patel et al.   Annual Review of Biochemistry

A Novel p53 Mutant Found in Iatrogenic Urothelial Cancers Is Dysfunctional and Can Be Rescued by a Second-site Global Suppressor Mutation

(2013) Adam F. Odell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulation of the Acetyltransferase TIP60-p53 Interplay by UHRF1 (Ubiquitin-like with PHD and RING Finger Domains 1)

(2013) Chao Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

(2013) Petra Kleiblova et al.   JOURNAL OF CELL BIOLOGY

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53

(2013) Caroline J. DeHart et al.   MOLECULAR & CELLULAR PROTEOMICS

Emerging roles for chromatin as a signal integration and storage platform

(2013) Aimee I. Badeaux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

(2013) S. Rokudai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

(2013) Oleg Timofeev et al.   Cell Reports

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

The Structural Basis for Control of Eukaryotic Protein Kinases

(2012) Jane A. Endicott et al.   Annual Review of Biochemistry

The impact of post-transcriptional regulation in the p53 network

(2012) J. A. Freeman et al.   Briefings in Functional Genomics

Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53

(2012) Lorna Jane Warnock et al.   CANCER BIOLOGY & THERAPY

The DNA binding and accumulation of p53 from breast cancer cell lines and the link with serine 15 phosphorylation

(2012) Debolina Ray et al.   CANCER BIOLOGY & THERAPY

Cell-type, Dose, and Mutation-type Specificity Dictate Mutant p53 Functions In Vivo

(2012) Ming Kei Lee et al.   CANCER CELL

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

p53 N-terminal phosphorylation: a defining layer of complex regulation

(2012) L. M. M. Jenkins et al.   CARCINOGENESIS

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop

(2012) Fabio Valenti et al.   CELL CYCLE

Global tumor protein p53/p63 interactome

(2012) Yiping Huang et al.   CELL CYCLE

Dietary downregulation of mutant p53 levels via glucose restriction

(2012) Olga Catalina Rodriguez et al.   CELL CYCLE

PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage

(2012) Yuwen Li et al.   CELLULAR SIGNALLING

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

(2012) Cynthia R Coffill et al.   EMBO REPORTS

Surf the Post-translational Modification Network of p53 Regulation

(2012) Bo Gu et al.   International Journal of Biological Sciences

Identification of Akt Interaction Protein PHF20/TZP That Transcriptionally Regulates p53

(2012) Sungman Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

(2012) Gaofeng Cui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis

(2012) Bernard Leroy et al.   NUCLEIC ACIDS RESEARCH

Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription

(2012) K Kim et al.   ONCOGENE

DNA-PK, ATM and ATR collaboratively regulate p53–RPA interaction to facilitate homologous recombination DNA repair

(2012) M A Serrano et al.   ONCOGENE

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

Functional p53 determines docetaxel sensitivity in prostate cancer cells

(2012) Chengfei Liu et al.   PROSTATE

DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

(2012) Laura Zannini et al.   Journal of Molecular Cell Biology

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Prolyl cis/trans isomerase signalling pathways in cancer

(2011) Martin Theuerkorn et al.   CURRENT OPINION IN PHARMACOLOGY

53BP1-mediated DNA double strand break repair: Insert bad pun here

(2011) Angela T. Noon et al.   DNA REPAIR

Beyond ATM: The protein kinase landscape of the DNA damage response

(2011) Ariel Bensimon et al.   FEBS LETTERS

Peptide-Protein Interactions Suggest That Acetylation of Lysines 381 and 382 of p53 Is Important for Positive Coactivator 4-p53 Interaction

(2011) Subrata Debnath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element

(2011) S. Emamzadah et al.   MOLECULAR CANCER RESEARCH

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

p53-Dependent Transcription and Tumor Suppression Are Not Affected in Set7/9-Deficient Mice

(2011) Bernhard Lehnertz et al.   MOLECULAR CELL

The Methyltransferase Set7/9 (Setd7) Is Dispensable for the p53-Mediated DNA Damage Response In Vivo

(2011) Stefano Campaner et al.   MOLECULAR CELL

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

(2011) Klara Acs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90

(2011) C. Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

(2011) D. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

14-3-3 proteins as signaling integration points for cell cycle control and apoptosis

(2011) Alexandra K. Gardino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

(2011) Yih-Cherng Liou et al.   TRENDS IN BIOCHEMICAL SCIENCES

To repress or not to repress: This is the guardian's question

(2011) John L. Rinn et al.   TRENDS IN CELL BIOLOGY

Regulation of p53 function by lysine methylation

(2011) Lisandra E West et al.   Epigenomics

Nitration of the Tumor Suppressor Protein p53 at Tyrosine 327 Promotes p53 Oligomerization and Activation

(2010) Vasily A. Yakovlev et al.   BIOCHEMISTRY

Influence of tetramerisation on site-specific post-translational modifications of p53: comparison of human and murine p53 tumour suppressor protein.

(2010) Lorna Jane Warnock et al.   CANCER BIOLOGY & THERAPY

Mdm2 and p53 are highly conserved from placozoans to man

(2010) David P. Lane et al.   CELL CYCLE

Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation

(2010) Sébastien Gillotin et al.   CELL CYCLE

Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo

(2010) M K Lee et al.   CELL DEATH AND DIFFERENTIATION

p53-family proteins and their regulators: hubs and spokes in tumor suppression

(2010) L Collavin et al.   CELL DEATH AND DIFFERENTIATION

Next-generation sequencing: emerging lessons on the origins of human cancer

(2010) Gerd P Pfeifer et al.   CURRENT OPINION IN ONCOLOGY

Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer

(2010) Benjamin Schumacher et al.   FEBS LETTERS

Regulation of the p53 pathway by ubiquitin and related proteins

(2010) Andreas Hock et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Expression of p53 Protein Phosphorylated at Serine 20 and Serine 392 in Malignant and Benign Ovarian Neoplasms

(2010) Julia K. Bar et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Cancer-associated p53 Tetramerization Domain Mutants

(2010) Rui Kamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression

(2010) Lisandra E. West et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway

(2010) Ricardo E. Perez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structural Insight into p53 Recognition by the 53BP1 Tandem Tudor Domain

(2010) Siddhartha Roy et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

Requirement of the ATM/p53 Tumor Suppressor Pathway for Glucose Homeostasis

(2010) H. L. Armata et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p53 Serine 18 Upregulates Apoptosis to Suppress Myc-Induced Tumorigenesis

(2010) H. K. Sluss et al.   MOLECULAR CANCER RESEARCH

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells

(2010) R Puca et al.   ONCOGENE

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

(2010) C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo

(2010) E. A. Slee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

(2009) S. Haupt et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

Modifications of p53: competing for the lysines

(2009) Stephanie Carter et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Plk1-mediated Phosphorylation of Topors Regulates p53 Stability

(2009) Xiaoming Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational Modifications Affect the Interaction of S100 Proteins with Tumor Suppressor p53

(2009) Jan van Dieck et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

(2009) D P Teufel et al.   ONCOGENE

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

MSL2 Promotes Mdm2-independent Cytoplasmic Localization of p53

(2008) Jan-Philipp Kruse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for 53BP1 Tudor Domain Recognition of p53 Dimethylated at Lysine 382 in DNA Damage Signaling

(2008) Ioulia Kachirskaia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomics Analysis of the Effects of Ionizing Radiation in Wild Type and p53K317RKnock-in Mouse Thymocytes

(2008) Lisa M. Miller Jenkins et al.   MOLECULAR & CELLULAR PROTEOMICS

Methylation of p53 by Set7/9 Mediates p53 Acetylation and Activity In Vivo

(2008) Julia K. Kurash et al.   MOLECULAR CELL

Arginine methylation regulates the p53 response

(2008) Martin Jansson et al.   NATURE CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY