The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies

Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs)

(2015) Hongmei Zhang et al.   BIOMATERIALS

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

(2015) Nina S. Funa et al.   Cell Stem Cell

The Anthelmintic Drug Niclosamide Inhibits the Proliferative Activity of Human Osteosarcoma Cells by Targeting Multiple Signal Pathways

(2015) Zhan Liao et al.   CURRENT CANCER DRUG TARGETS

FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus

(2015) Wenqi Wang et al.   DEVELOPMENTAL CELL

The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling

(2015) Graeme M. Birdsey et al.   DEVELOPMENTAL CELL

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

(2015) Jing Cai et al.   GENES & DEVELOPMENT

Targeting Wnts at the Source--New Mechanisms, New Biomarkers, New Drugs

(2015) B. Madan et al.   MOLECULAR CANCER THERAPEUTICS

Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition

(2015) Chengfei Liu et al.   PROSTATE

LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling

(2015) Lu Yang et al.   STEM CELLS

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

Repairing organs: lessons from intestine and liver

(2015) Helmuth Gehart et al.   TRENDS IN GENETICS

Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

(2015) Hua Tian et al.   Cell Reports

Focal Chromosomal Copy Number Aberrations Identify CMTM8 and GPR177 as New Candidate Driver Genes in Osteosarcoma

(2015) Joeri Both et al.   PLoS One

Safely targeting cancer stem cells via selective catenin coactivator antagonism

(2014) Heinz-Josef Lenz et al.   CANCER SCIENCE

Wntless (GPR177) expression correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia via Wnt signaling

(2014) Shyh-Shin Chiou et al.   CARCINOGENESIS

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Wnt–Notch signalling crosstalk in development and disease

(2014) Giovanna M. Collu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells

(2014) Wenyan Lu et al.   CELLULAR SIGNALLING

Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8

(2014) Martijn H. van den Bosch et al.   CELLULAR SIGNALLING

Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer

(2014) C. Liu et al.   CLINICAL CANCER RESEARCH

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

(2014) Z. Kabiri et al.   DEVELOPMENT

WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion

(2014) Jia Yu et al.   DEVELOPMENTAL CELL

Concentration-dependent effects of WNTLESS on WNT1/3A signaling

(2014) Lisa M. Galli et al.   DEVELOPMENTAL DYNAMICS

Inhibition of Wnt/β-catenin pathway by niclosamide: A therapeutic target for ovarian cancer

(2014) Rebecca C. Arend et al.   GYNECOLOGIC ONCOLOGY

Regulation of Induced Pluripotent Stem (iPS) Cell Induction by Wnt/β-Catenin Signaling

(2014) Peilin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of wntless (WLS) expression in gastric, ovarian and breast cancers reveals a strong association with HER2 overexpression

(2014) Jonathan Stewart et al.   MODERN PATHOLOGY

Effect of Niclosamide on Basal-like Breast Cancers

(2014) A. I. Londono-Joshi et al.   MOLECULAR CANCER THERAPEUTICS

Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice

(2014) L. Tumova et al.   MOLECULAR CANCER THERAPEUTICS

In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators

(2014) Wen-Hui Lien et al.   NATURE CELL BIOLOGY

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Pygo2 regulates  -catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia

(2014) P. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells

(2014) J. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Signaling mechanisms of the epithelial-mesenchymal transition

(2014) D. M. Gonzalez et al.   Science Signaling

Targeting the β-catenin nuclear transport pathway in cancer

(2014) Cara Jamieson et al.   SEMINARS IN CANCER BIOLOGY

Bone Morphogenetic Protein-9 Effectively Induces Osteo/Odontoblastic Differentiation of the Reversibly Immortalized Stem Cells of Dental Apical Papilla

(2014) Jinhua Wang et al.   STEM CELLS AND DEVELOPMENT

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

(2013) Y. Zhang et al.   CANCER RESEARCH

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

(2013) T. Lau et al.   CANCER RESEARCH

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Gpr177 regulates pulmonary vasculature development

(2013) M. Jiang et al.   DEVELOPMENT

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours

(2013) Peter Wend et al.   EMBO JOURNAL

Tankyrases as drug targets

(2013) Lari Lehtiö et al.   FEBS Journal

Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/β-catenin/CBP pathway

(2013) Kaijie He et al.   INTERNATIONAL JOURNAL OF CANCER

The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms

(2013) H. Yamamoto et al.   JOURNAL OF CELL SCIENCE

Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

(2013) E J Gang et al.   ONCOGENE

Gpr177 Deficiency Impairs Mammary Development and Prohibits Wnt-Induced Tumorigenesis

(2013) Eri Ohfuchi Maruyama et al.   PLoS One

The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium

(2013) Tomoyo Sasaki et al.   PLoS One

Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation

(2013) Eve Kandyba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt7b Is an Important Intrinsic Regulator of Hair Follicle Stem Cell Homeostasis and Hair Follicle Cycling

(2013) Eve Kandyba et al.   STEM CELLS

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

(2013) Oksana Voloshanenko et al.   Nature Communications

Wnt signaling in bone formation and its therapeutic potential for bone diseases

(2013) Jeong Hwan Kim et al.   Therapeutic Advances in Musculoskeletal Disease

Wnt-Notch signalling: An integrated mechanism regulating transitions between cell states

(2012) Silvia Muñoz-Descalzo et al.   BIOESSAYS

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells

(2012) Wenyan Lu et al.   CELLULAR SIGNALLING

Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis

(2012) Xuming Zhu et al.   DEVELOPMENTAL BIOLOGY

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

Glucose-Induced β-Catenin Acetylation Enhances Wnt Signaling in Cancer

(2012) Ana Chocarro-Calvo et al.   MOLECULAR CELL

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

(2012) Min Yu et al.   NATURE

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Wntless functions in mature osteoblasts to regulate bone mass

(2012) Z. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of oncogenic Wnt signaling through direct targeting of  -catenin

(2012) T. N. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling

(2012) K. Takada et al.   Science Translational Medicine

The Hippo signaling pathway and stem cell biology

(2012) Azucena Ramos et al.   TRENDS IN CELL BIOLOGY

Wnt Pathway Regulation of Embryonic Stem Cell Self-Renewal

(2012) B. J. Merrill   Cold Spring Harbor Perspectives in Biology

Wnt Signaling Orchestration with a Small Molecule DYRK Inhibitor Provides Long-Term Xeno-Free Human Pluripotent Cell Expansion

(2012) Kouichi Hasegawa et al.   Stem Cells Translational Medicine

The R-spondin protein family

(2012) Wim BM de Lau et al.   GENOME BIOLOGY

Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction

(2011) Wang Tian et al.   BIOCHEMISTRY

Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells

(2011) C. Schaniel et al.   BLOOD

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations

(2011) T. Osada et al.   CANCER RESEARCH

Wnt to Notch Relay Signaling Induces Definitive Hematopoiesis

(2011) Dirk Loeffler et al.   Cell Stem Cell

BMP-9 Induced Osteogenic Differentiation of Mesenchymal Stem Cells: Molecular Mechanism and Therapeutic Potential

(2011) Gaurav Luther et al.   CURRENT GENE THERAPY

Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development

(2011) Jiang Fu et al.   DEVELOPMENTAL DYNAMICS

The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis

(2011) Iris Augustin et al.   EMBO Molecular Medicine

Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations

(2011) Hanna Taipaleenmäki et al.   EXPERIMENTAL CELL RESEARCH

Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin

(2011) Wei Wei et al.   Molecular Cancer

CREBBP mutations in relapsed acute lymphoblastic leukaemia

(2011) Charles G. Mullighan et al.   NATURE

A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

(2011) Wilson K. Clements et al.   NATURE

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway

(2011) Wenyan Lu et al.   PLoS One

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

(2011) Desheng Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

(2011) F. C. Gonsalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

AV-65, a novel Wnt/β-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model

(2011) H Yao et al.   Blood Cancer Journal

The Therapeutic Potential of the Wnt Signaling Pathway in Bone Disorders

(2011) Eric R. Wagner et al.   Current Molecular Pharmacology

Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture

(2010) S. Singbrant et al.   BLOOD

New avenues to target Wnt/β-catenin signaling

(2010) Folkert Verkaar et al.   DRUG DISCOVERY TODAY

Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling

(2010) Monther Abu-Remaileh et al.   EMBO JOURNAL

Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and β-catenin/Wnt pathways

(2010) Sara Previdi et al.   EUROPEAN JOURNAL OF CANCER

Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling

(2010) He   INTERNATIONAL JOURNAL OF ONCOLOGY

Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization

(2010) C. Metcalfe et al.   JOURNAL OF CELL SCIENCE

Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma

(2010) Sarah Beseme Nambotin et al.   JOURNAL OF HEPATOLOGY

Allosteric Remodelling of the Histone H3 Binding Pocket in the Pygo2 PHD Finger Triggered by Its Binding to the B9L/BCL9 Co-Factor

(2010) Thomas C.R. Miller et al.   JOURNAL OF MOLECULAR BIOLOGY

Current and emerging concepts in tumour metastasis

(2010) Caroline Coghlin et al.   JOURNAL OF PATHOLOGY

Wnt Inhibitory Factor 1 Decreases Tumorigenesis and Metastasis in Osteosarcoma

(2010) E. M. Rubin et al.   MOLECULAR CANCER THERAPEUTICS

Tetrandrine Inhibits Wnt/ -Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer

(2010) B.-C. He et al.   MOLECULAR PHARMACOLOGY

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin

(2010) E Lavergne et al.   ONCOGENE

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Wnt Trafficking: New Insights into Wnt Maturation, Secretion and Spreading

(2010) Fillip Port et al.   TRAFFIC

The Sex-Determining Region Y-Box 4 and Homeobox C6 Transcriptional Networks in Prostate Cancer Progression

(2009) Carlos S. Moreno   AMERICAN JOURNAL OF PATHOLOGY

The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling

(2009) Minyong Chen et al.   BIOCHEMISTRY

2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer

(2009) Zecheng Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

(2009) Laura Arce et al.   BMC CANCER

MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3

(2009) Ingrid Revet et al.   CANCER LETTERS

Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/ -Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth

(2009) N. Baryawno et al.   CANCER RESEARCH

Wnt Signaling Stimulates Transcriptional Outcome of the Hedgehog Pathway by Stabilizing GLI1 mRNA

(2009) F. K. Noubissi et al.   CANCER RESEARCH

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics

(2009) Isabelle Bisson et al.   CELL RESEARCH

Metastable Pluripotent States in NOD-Mouse-Derived ESCs

(2009) Jacob Hanna et al.   Cell Stem Cell

Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant  -Catenin Activation in Colon Cancer

(2009) S. Naik et al.   CLINICAL CANCER RESEARCH

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

New Insights into the Role of Hedgehog Signaling in Gastrointestinal Development and Cancer

(2009) Byeong–Moo Kim et al.   GASTROENTEROLOGY

Reduced Level of Smoothened Suppresses Intestinal Tumorigenesis by Down-Regulation of Wnt Signaling

(2009) Sumimasa Arimura et al.   GASTROENTEROLOGY

Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver

(2009) Lisa Longato et al.   HEPATOLOGY

Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors

(2009) Dolores López-Terrada et al.   HUMAN PATHOLOGY

IRS1Regulation by Wnt/β-Catenin Signaling and Varied Contribution ofIRS1to the Neoplastic Phenotype

(2009) Guido T. Bommer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled

(2009) David Grandy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

(2009) Maya Kansara et al.   JOURNAL OF CLINICAL INVESTIGATION

The PHD domain is required to link Drosophila Pygopus to Legless/β-catenin and not to histone H3

(2009) Roman Kessler et al.   MECHANISMS OF DEVELOPMENT

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling

(2009) Frédéric Varnat et al.   MECHANISMS OF DEVELOPMENT

Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells

(2009) Wei Wei et al.   Molecular Cancer

EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin

(2009) Haitao Ji et al.   MOLECULAR CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia

(2009) Hoang Nguyen et al.   NATURE GENETICS

Modulation of the β-Catenin Signaling Pathway by the Dishevelled-Associated Protein Hipk1

(2009) Sarah H. Louie et al.   PLoS One

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation

(2009) J. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation

(2008) T. C. Luis et al.   BLOOD

Crosstalk of hedgehog and Wnt pathways in gastric cancer

(2008) Kosuke Yanai et al.   CANCER LETTERS

Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating  -Catenin Signaling

(2008) R. Pai et al.   CANCER RESEARCH

Periodic Activation of Wnt/β-Catenin Signaling Enhances Somatic Cell Reprogramming Mediated by Cell Fusion

(2008) Frederic Lluis et al.   Cell Stem Cell

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency

(2008) Alexander Marson et al.   Cell Stem Cell

Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood

(2008) M. Cristina Nostro et al.   Cell Stem Cell

Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenstrom's Macroglobulinemia

(2008) A. M. Roccaro et al.   CLINICAL CANCER RESEARCH

Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells

(2008) Katharina Salome Minke et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism

(2008) Ke Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad7 Stabilizes β-Catenin Binding to E-cadherin Complex and Promotes Cell-Cell Adhesion

(2008) Yi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC6 Is Required for Epidermal Growth Factor-induced β-Catenin Nuclear Localization

(2008) Yu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation

(2008) Mikhail V. Semënov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction

(2008) Xiao-qing Gan et al.   JOURNAL OF CELL BIOLOGY

In vivo role of lipid adducts on Wingless

(2008) X. Franch-Marro et al.   JOURNAL OF CELL SCIENCE

BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/β-catenin signalling

(2008) Ni Tang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density

(2008) K. Ellwanger et al.   MOLECULAR AND CELLULAR BIOLOGY

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

(2008) Kyung-Ah Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling

(2008) Steven Hoseong Yang et al.   NATURE GENETICS

Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis

(2008) X Li et al.   ONCOGENE

The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair

(2008) M. P. Alfaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Receptor Substrate-1 Deficiency Promotes Apoptosis in the Putative Intestinal Crypt Stem Cell Region, Limits Apcmin/+Tumors, and Regulates Sox9

(2007) Nicole M. Ramocki et al.   ENDOCRINOLOGY