Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

Functional Comparison of Human Adenomatous Polyposis Coli (APC) and APC-Like in Targeting Beta-Catenin for Degradation

(2013) Jean Schneikert et al.   PLoS One

Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

(2012) Henner F. Farin et al.   GASTROENTEROLOGY

Identification of a cKit+ Colonic Crypt Base Secretory Cell That Supports Lgr5+ Stem Cells in Mice

(2012) Michael E. Rothenberg et al.   GASTROENTEROLOGY

Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-boundO-Acyltransferase Porcupine

(2012) Michael E. Dodge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell Proliferation

(2012) Shree Harsha Vijaya Chandra et al.   PLoS One

Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases

(2011) Sebastian M. Dieter et al.   Cell Stem Cell

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis

(2011) Iris Augustin et al.   EMBO Molecular Medicine

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC

(2011) Jean Schneikert et al.   HUMAN MOLECULAR GENETICS

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

(2011) David M. Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

(2011) James A. Stefater III et al.   NATURE

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation

(2011) Natalia Lyashenko et al.   NATURE CELL BIOLOGY

Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis

(2011) A Rohlin et al.   ONCOGENE

Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/ -catenin signaling

(2011) A. Scholer-Dahirel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway

(2010) Christophe Fuerer et al.   PLoS One

Smed-Evi/Wntless is required for  -catenin-dependent and -independent processes during planarian regeneration

(2009) T. Adell et al.   DEVELOPMENT

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Contribution of the 15 amino acid repeats of truncated APC to β-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients

(2009) E M Kohler et al.   ONCOGENE

Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells

(2008) Sebastian Baehs et al.   CANCER LETTERS

APC Is Essential for Targeting Phosphorylated β-Catenin to the SCFβ-TrCP Ubiquitin Ligase

(2008) YunYun Su et al.   MOLECULAR CELL

The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network

(2007) Tatyana Y. Belenkaya et al.   DEVELOPMENTAL CELL