Wai Lo

United States UConn

Article

Commented on Passive monitoring by smart toilets for precision health
This group won an Ig Nobel prize in 2023 for their work on the Precision Health toilet, a “smart toilet” device capable of detecting diseases from excreta.

Article

Commented on Measurement and quantification of cadaveric nasal hairs
The 2023 Ig Nobel Medicine Prize was awarded to Christine Pham, Bobak Hedayati, Kiana Hashemi, Ella Csuka, Tiana Mamaghani, Margit Juhasz, Jamie Wikenheiser, and Natasha Mesinkovska, for using cadavers to explore whether there is an equal number of hairs in each of a person’s two nostrils. They documented their research in the study “The Quantification and Measurement of Nasal Hairs in a Cadaveric Population,” published in the International Journal of Dermatology.

Article

Commented on Necrobotics: Biotic Materials as Ready‐to‐Use Actuators
This is a very interesting article. The engineers at Rice University in Houston, Texas, has made robotic grippers from dead spiders. And they’re being recognized for their creation of the mechanical gripping tools. They were awarded an Ig Nobel Prize in 2023.

Journal

Commented on JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
This journal has rapid publication rate. According to the journal, time to first decision - 3 days for initial decision without review, 40 days with review. Time to publication - 2-22 days for online publication and 39 days for publication in print.

Journal

Commented on Journal of the American Heart Association
This journal has a rapid publication. According to the journal, the time to publication - 21 days from acceptance.

Journal

Commented on BIOLOGY BULLETIN
The Biology Bulletin is a peer-reviewed journal on all topics in biology. The main attention is paid to fundamental research in the field of theoretical and evolutionary biology, cell biology, biochemistry, developmental biology, zoology, genetics, botany, plant physiology, animal and human physiology, and ecology.

Journal

Commented on ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Annals of the New York Academy of Sciences is a multidisciplinary journal publishing research in most areas of science. Each issue stimulates new thinking by presenting a wide array of research across many institutions and fields.

Article

Commented on Interim Recommendations for Use of Bivalent mRNA COVID-19 Vaccines for Persons Aged ≥6 Months — United States, April 2023
Transition to a single bivalent COVID-19 vaccine dose for most persons, with additional doses for persons at increased risk for severe disease, facilitates implementation of simpler, more flexible recommendations. All persons aged ≥6 months should receive ≥1 bivalent vaccine dose.

Article

Commented on Boosting with updated COVID-19 mRNA vaccines
Certain evidence shows that boosting with updated mRNA vaccines that target SARS-CoV-2 variants stimulates better neutralizing antibody responses than homologous boosters.

Article

Commented on COVID ‐19 mRNA vaccines and myopericarditis
This review paper shows that COVID-19 mRNA vaccines and associated myopericarditis including risk factors, proposed mechanism, and treatment including management strategies for refractory disease.

Article

Commented on Carrier-free, functionalized pure drug nanorods as a novel cancer-targeted drug delivery platform
Seems interesting! How does the novel carrier-free, pure drug nanorod-based 1D drug delivery system (DDS) enhance drug efficiency and selectivity towards cancer cells compared to traditional encapsulated drug delivery methods?

Article

Commented on A side-effect free method for identifying cancer drug targets
The challenge of identifying drug targets without adverse effects is highlighted by the risk of drugs being withdrawn due to the side effects associated with pleiotropic genes. An integrated approach using protein interactome analysis, particularly focusing on k-core, functional connectivity, and centrality (KFC) measures, has been proposed to simplify disease complexity and pinpoint effective drug targets in cancer. By analyzing proteins from experimental pathway databases and their interactions, this method has identified reasons for drug withdrawals and shortlisted ten proteins as promising candidates for future drug development, aiming to mitigate the risks associated with earlier pharmaceutical approaches.

Article

Commented on Drug-free Nanotherapies for Cancer Treatment
Technological advancements in cancer treatment have aimed to surpass traditional methods, yet they often result in harmful effects on healthy tissues due to cytotoxicity and limitations in drug delivery. This review highlights the potential of nanotherapy, employing drug-free macromolecules and advanced delivery systems like molecularly imprinted polymers and nanotubes, to enhance therapeutic efficacy and selectivity while minimizing adverse effects on non-target tissues.

Article

Commented on Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery
Chemotherapeutic drugs acting as immunogenic cell death (ICD) inducers show promise in transforming the immunosuppressive tumor microenvironment into immune-responsive tumors, with their efficacy enhanced through nanomedicine to overcome poor pharmacokinetics and tumor targeting. Tumor-activated, carrier-free prodrug nanoparticles (PDNPs) offer a solution to conventional nanoparticle limitations, improving drug delivery safety and effectiveness, and when combined with other therapies, significantly enhance responses to immune checkpoint blockade therapy.