Wai Lo

United States UConn

Article

Commented on Protein partners of plant ubiquitin-specific proteases (UBPs)
Ubiquitin-specific proteases (UBPs), a category of deubiquitinases (DUBs), are crucial for regulating plant development and stress responses, though their functional mechanisms largely remain to be elucidated. Recent progress in identifying UBPs' functional partners and understanding their molecular interactions offers promising avenues for uncovering the roles of protein deubiquitination in plants, potentially leading to a deeper comprehension of UBPs' physiological importance.

Article

Commented on Emerging potential of ubiquitin-specific proteases and ubiquitin-specific proteases inhibitors in breast cancer treatment
Ubiquitin-specific peptidases (USPs) play a crucial role in the etiology and progression of breast cancer, representing promising therapeutic targets. This review highlights the involvement of various USPs in breast cancer and summarizes the inhibitors investigated for treatment, emphasizing the potential of USPs as a focus for developing effective therapies despite none being clinically approved yet.

Article

Commented on Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders
Ubiquitination and deubiquitination are key reversible processes that affect protein characteristics, with ubiquitin-specific proteases (USPs) playing a significant role in metabolic diseases by either improving or worsening conditions like hyperglycemia, diabetic nephropathy, NAFLD, and atherosclerosis. USPs have both positive and negative impacts on these conditions, with specific USPs associated with various effects in different tissues, indicating their complex roles in energy metabolism and related disorders.

Article

Commented on Ubiquitin-specific proteases as cancer drug targets
Ubiquitin-specific proteases are deubiquitinating enzymes involved in the removal of ubiquitin from specific protein substrates resulting in protein salvage from proteasome degradation, regulation of protein localization or activation. DNA alteration and overexpression in different cancer types, as well as involvement in many cancer-associated pathways, make ubiquitin-specific proteases attractive for the cancer drug discovery purposes. Their proteolytic function associated to available structural biology data reinforce their potential for pharmacological interference. The authors reviewed this class of enzymes as cancer drug targets in terms of validation and draggability.

Article

Commented on Advances in natural killer cell therapies for breast cancer
Breast cancer (BC), the leading cause of cancer death among women, sees 30% of cases advancing to metastatic disease, with current treatments unable to cure and average survival around 2 years. Recent advances in adoptive cell therapy, specifically NK and CAR-NK cell immunotherapy, offer new hope for BC treatment through targeting cancer cells with enhanced immune responses without harming healthy cells.

Article

Commented on iPSC-Derived Natural Killer Cell Therapies - Expansion and Targeting
The development of allogeneic natural killer (NK) cell therapies for cancer treatment, particularly against hematologic malignancies, has advanced with clinical trials exploring NK cells derived from various sources. Recent progress includes genetic enhancements for better tumor targeting and methods to increase the expansion and persistence of induced pluripotent stem cell (iPSC)-derived NK cells, promising future improvements in NK cell-based treatments for both hematologic and solid tumors.

Article

Commented on High prevalence of clade 8 Escherichia coli O157:H7 isolated from retail meat and butcher shop environment
Escherichia coli O157:H7, a significant food safety threat causing morbidity and mortality worldwide, has diverse genetic profiles in Argentina, with 70% of strains linked to severe disease outcomes belonging to clade 8. This study analyzed 20 STEC O157:H7 strains from ground beef and environmental samples, revealing high genetic diversity and identifying two main lineages (clade 8 and clade 6) through SNP analysis.

Webinar

Commented on Semiconductor Industry: Present & Future
He is from one of the most powerful companies (TMSC) in the world.

Article

Commented on AI in Health science: A Perspective
With minimum human participation, AI is quickly growing in healthcare, and numerous AI applications have been created to address current issues.

Journal

Commented on Med
Not sure if this is published by the Cell Press. https://www.cell.com/med/home

Journal

Commented on CELL
I found this is a very good option: Cell Press Multi-Journal Submission helps us to find the right fit for our research paper quickly and easily by considering it simultaneously for multiple Cell Press journals of our choice. Choosing Multi-Journal Submission increases the likelihood that your paper will be formally peer reviewed at Cell Press, helps us avoid serial rounds of review, and shortens the time needed to go from submission to publication.

Funding

Commented on Science for Peace and Security Programme (SPS Programme)
Just notice that this is funded by NATO. Wondering who will get this type of finding.

Article

Commented on Acute Effects of Coffee Consumption on Health among Ambulatory Adults
Good article recently published in NEJM. In short, in this randomized trial, the consumption of caffeinated coffee did not result in significantly more daily premature atrial contractions than the avoidance of caffeine.

Article

Commented on Energy Drinks and atrial fibrillation in young adults
Interesting article! The study highlights the potential link between high consumption of Energy Drinks (EDs), particularly when mixed with alcohol, and the onset of atrial fibrillation (AF) in young individuals, evidenced by three clinical cases. It underscores the need for heightened awareness regarding cardiac risks associated with EDs among young people, due to the combined effects of caffeine and other substances in these drinks.

Article

Commented on Influence of coffee and caffeine consumption on atrial fibrillation in hypertensive patients
Consumption of coffee and caffeine impacts the natural resolution of atrial fibrillation. Individuals without high blood pressure who rarely consume coffee have a higher chance of their arrhythmia resolving on its own within 48 hours from when symptoms begin. In contrast, patients with high blood pressure exhibit a U-shaped correlation between their coffee intake and the natural resolution of atrial fibrillation; those who consume a moderate amount of coffee are less likely to experience this spontaneous resolution. Furthermore, patients with an enlarged left ventricle experience a decreased likelihood of their arrhythmia resolving without intervention.