Wai Lo

United States UConn

Article

Commented on Burning Fat to Fuel EVs
Very interesting perspective. The study by Huang et al. discovered that lipolysis activates the DNA repair enzyme p53, leading to the release of extracellular vesicles (AdEVs) and free proteins like fatty acid binding protein 4 (FABP4) from adipocytes. This process is suppressed when p53 is inhibited. The research also highlights a role for the mammalian target of rapamycin (mTOR) pathway in this process, suggesting that p53 and mTOR are important regulators of AdEV release. These findings link lipolysis, p53 activation, and the release of AdEVs, offering insights into potential therapeutic targets for metabolic diseases like obesity.

Article

Commented on Structures of human dynein in complex with the lissencephaly 1 protein, LIS1
This research elucidates the molecular interaction between human dynein and the lissencephaly 1 protein (LIS1), crucial for understanding mechanisms underlying diseases like type-1 lissencephaly. By analyzing cryo-EM structures of the dynein-LIS1 complex, the study highlights differences in dynein-LIS1 interactions between yeast and humans, offering insights into the role of LIS1 in dynein activation and providing a framework for investigating disease-related mutations within this complex.

Article

Commented on Lis1-dynein drives corona compaction and limits erroneous microtubule attachment at kinetochores
The study investigates the role of Lis1, a key regulator of the motor protein dynein, in mitotic cell division, particularly how it aids in the removal of the fibrous corona from kinetochores, a critical process for proper chromosome segregation. HeLa cells lacking Lis1 exhibit an inability to disassemble the corona, leading to delays in metaphase due to ongoing spindle assembly checkpoint activation. The research demonstrates that while kinetochore-bound Lis1-dynein is crucial for accurate microtubule attachment, Lis1's role in corona disassembly can also be performed by Lis1 located in the cytoplasm. These findings highlight Lis1's essential contribution to dynein's function in ensuring the proper progression of mitosis and preventing chromosome mis-segregation, which is vital for understanding diseases like lissencephaly that are linked to Lis1 mutations.

Article

Commented on Engineering Novel Actin-Based Molecular Motors from the Microtubule-Based Motor Dynein
Interesting article! This research explores the creation of novel biomolecular motors by combining protein modules from different cytoskeletal systems, resulting in hybrid motors that merge a dynein motor core with actin-binding proteins (ABPs). These hybrids demonstrate the capability to drive actin filament movement in a nucleotide-dependent manner, with the unique ability to reverse the direction of movement by altering the arrangement of the motor core and ABP.

Article

Commented on JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport
The findings highlight the RH1 domains of JIP3 as critical sites for motor protein interaction, underscoring the complex interplay between JIP3-bound dynein and kinesin-1 in the bidirectional transport of organelles. This study sheds light on the molecular mechanisms by which JIP3 coordinates motor proteins to prevent lysosome accumulation in neurons, offering insights into the broader understanding of axonal transport and its implications for neurobiology.

Journal

Commented on JOURNAL OF CATALYSIS
The JOURNAL OF CATALYSIS is recruiting volunteer reviewers for their journal, please register your name in this site: https://www.sciencedirect.com/journal/journal-of-catalysis/about/volunteer-to-review

Journal

Commented on Biomedicines
Biomedicines is recruiting volunteer reviewers. Reviewers are responsible for regularly providing timely, high-quality reports on manuscripts submitted to the journal. More information about the role is available at: https://www.mdpi.com/reviewers.

Journal

Commented on RSC Advances
Royal Society of Chemistry is looking for volunteer reviewers to review their submissions. Please register here: https://www.rsc.org/journals-books-databases/author-and-reviewer-hub/reviewer-information/how-to-become-a-reviewer/

Journal

Commented on BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Biochemical and Biophysical Research Communications is recruiting volunteer to review their papers. You can register your information here: https://www.sciencedirect.com/journal/biochemical-and-biophysical-research-communications/about/news

Funding

Commented on International Research Ethics Education and Curriculum Development Award (R25 Clinical Trial Not Allowed)
Looks like there is another call for minority and underfunded universities or colleges.

Article

Commented on Robotics: Science and Systems
The conference Robotics: Science and Systems was held at the University of Washington in Seattle, from June 28 to July 1, 2009. More than 300 international researchers attended this single-track conference to learn about the most exciting robotics research and most advanced robotic systems. The program committee selected 39 papers out of 154 submissions. The program also included invited talks. The plenary presentations were complemented by workshops.

Journal

Commented on Foundations and Trends in Machine Learning
This ranks the top AI related journal. Current impact factor is 32.8. Published by NOW Publishing LLC.

Journal

Commented on Nature Machine Intelligence
AI / machine learning related journal published by Nature. They launched it in 2019 but the current impact factor is already 23.8 and it is rising. I feel it has the potential to beat the Nature-Nature.

Article

Commented on Tctex-1, a Novel Interaction Partner of Rab3D, Is Required for Osteoclastic Bone Resorption
The interaction between dynein light chain Tctex-1 and osteoclast bone resorption regulator Rab3D plays a key role in modulating the bone-resorbing activities of osteoclasts.

Hub

Commented on AI in education, teaching, learning
AI allows students at all grade levels to interact with the world around them, learn about themselves and other people and explore STEM in new ways.