This study developed hydroxyapatite from the CaCO3-rich byproduct of sugar beet processing, Carbocal®, using a hydrothermal reactor, demonstrating its potential as a sustainable, economically viable bone filler and osteoinductive implant surface enhancer with bioactivity comparable to natural hydroxyapatite.
Interesting scoping review. How does platelet-rich fibrin (PRF) influence the proliferation, differentiation, and mineralization of bone cells in vitro, and what are the implications of these effects for its therapeutic potential in wound healing and bone regeneration, as evidenced by the systematic review of 76 studies conducted up to August 2023?
What impact does the incorporation of bioactive glass (BG) and silver nanoparticle (SNP) solutions into hydraulic calcium silicate cement (HCSC) have on the antibacterial properties of dentin surfaces and the dentin/material interface when compared to other dental cements such as Biodentine, TotalFill BC RRM putty, and Intermediate Restorative Material (IRM)?
Interesting paper. This study explores the feasibility of using protective, encapsulating polymer hydrogels in a non-invasive cell spray format for better post-transplant cell viability. Various concentrations of type I rat tail collagen hydrogels were tested for deliverability, and cell-enriched hydrogels containing mouse cortical astrocytes were sprayed onto culture substrates. Results showed high astrocyte viability (>80%) post-spraying with maintained marker expression and proliferative potential, indicating that this method could enhance current cell delivery approaches.
The amniotic membrane has been used in various tissue repair applications, but the lack of standardized production methods has resulted in diverse allograft products with varying clinical responses. This review aims to examine the properties, processing, and preservation methods of different human allograft membranes and their applications in tissue engineering and regenerative medicine.
This is an editor's pick article. Briefly, volumetric muscle loss (VML) is a traumatic injury resulting in the destruction of at least 20% of skeletal muscle mass, often treated with autologous tissue transfer, which has a high failure rate due to necrosis or infection. Researchers are developing collagen scaffolds with tunable pore sizes to promote myoblast infiltration and alignment, aiming to improve muscle regeneration and functionality, with the ultimate goal of creating an effective off-the-shelf treatment for VML injuries.
This study establishes a zebrafish embryo xenograft model to observe the dynamic interactions between tumor cells and their microenvironment, revealing that while VEGF signaling inhibition suppresses localized tumor growth, it enhances neutrophil migration, tumor invasiveness, and micrometastasis. The findings demonstrate the in vivo cooperation between VEGF signaling and myeloid cells in metastasis, offering new insights into how VEGFR targeting can inadvertently promote tumor invasiveness.
This review discusses recent advances in intravital imaging (IVI) of mammalian cancer models, highlighting how IVI enhances our understanding of the tumor microenvironment's role in cancer progression and metastasis, and aids in the development of novel treatments and therapies. It also covers new techniques, fluorescent reporters, biosensors, clinical applications, and addresses remaining challenges and future perspectives in the field.
The speaker is the PI of the newly-established Actuate Lab in the Department of Physics. She currently works on both in silico and ex silico engineering of biomolecular crystals, primarily for application areas in eco-friendly sensing and pharmaceuticals.
The clinical microbiome refers to the diverse community of microorganisms, such as bacteria, fungi, and viruses, that reside in or on the human body. Serving as a crucial interface between the body and the external environment, the microbiome plays a vital role in maintaining health. However, disruptions to the microbiome can result in significant health issues.
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Ear lobe creases (ELC) were found more in males and there was a statistically significant positive association between ELC and diabetes, hypertension, heart disease in both sexes. Thus, they suggested to have a routine screening during physical exam.
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