Wai Lo

United States UConn

期刊

评论了 Coffee Science
Looks like this is a Brazilian journal that specializes in coffee science and production.

期刊

评论了 AI
Not sure if this is a real journal.

期刊

评论了 AI MAGAZINE
The name “magazine” is a bit confusing but it is actually a peer reviewed journal that has a long history.

论文

评论了 An integrated Asian human SNV and indel benchmark established using multiple sequencing methods
INteresting work!!! This study established an Asian human variation benchmark using a stabilized cell line from a Chinese Han volunteer, generating comprehensive sequencing data and identifying high-confidence variations, which will aid future sequencing-based clinical developments.

论文

评论了 Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development
This paper presents novel methods for developing PDAC organoids from PDX tumors and matched primary cell lines, showing that these organoid models retain similar transcriptomic signatures to their original tumors, thus providing valuable resources for high-throughput screening, functional genomics, and tumor microenvironment studies.

论文

评论了 Establishment and characterization of a new human colon cancer cell line, PUMC-CRC1
Colorectal cancer (CRC) is a prevalent and deadly gastrointestinal cancer, necessitating new CRC cell lines for research. The newly established PUMC-CRC1 cell line, derived from a 47-year-old Chinese female, exhibits genetic stability and complex chromosomal abnormalities, making it a valuable model for studying CRC mechanisms and evaluating treatments.

论文

评论了 Short Acquisition Time Super-Resolution Ultrasound Microvessel Imaging via Microbubble Separation
Super-resolution ultrasound localization microscopy (ULM) achieves high-resolution microvascular imaging but is limited by the need for dilute microbubble (MB) concentrations and long acquisition times. This paper proposes a method to separate overlapping MB events into sub-populations based on flow dynamics, enabling robust ULM imaging with higher MB concentrations, significantly reducing acquisition time and demonstrating potential for clinical application.

海报

评论了 Prediction of Antimicrobial Peptides Using Machine Learning Approach
Great work! This is one of the examples for drug discovery using AI or machine learning.

论文

评论了 Coffee Consumption and Kidney Function: A Mendelian Randomization Study
This study provides evidence of a beneficial effect of coffee on kidney function. Given widespread coffee consumption and limited interventions to prevent CKD incidence and progression, this could have significant implications for global public health in view of the increasing burden of CKD worldwide.

论文

评论了 Association of coffee consumption and chronic kidney disease: A meta-analysis
Their study demonstrates no significant association between coffee consumption and CKD in males. However, future studies are required to assess a potential inverse association between coffee consumption and risk for developing CKD in females.

论文

评论了 Coffee Intake and Chronic Kidney Disease
They have concerns about the lack of a dose-response relationship and the need for further research on coffee intake levels, as well as the insufficient discussion on the effect of smoking on CKD, which warrants simultaneous consideration of smoking and albuminuria (proteinuria) in such assessments.

论文

评论了 Coffee and kidney disease
Interesting article!

论文

评论了 Direct observation of DNA alterations induced by a DNA disruptor
In this study, they employed a single-molecule electrical detection method to observe directly how DNA alterations influence transcription factor binding, specifically examining the effects of the nucleic acid analogue trifluridine (FTD) on p53 transcription factor binding motifs in cancer cells. Their findings reveal that approximately 10% of the p53 binding regions incorporated FTD after a 5-month exposure, resulting in diminished p53 binding and suggesting that single-molecule detection is an effective tool for elucidating the impacts of DNA alterations on transcriptional activity.

论文

评论了 Benchmarking germline CNV calling tools from exome sequencing data
Whole-exome sequencing is gaining favor over microarray analysis due to its cost-effectiveness and ability to detect copy number variations (CNV) across various sizes, though previous studies have shown a high rate of false positives among popular CNV calling tools. Their comprehensive analysis using a standardized CNV reference set for the NA12878 sample evaluated 16 germline CNV calling tools, revealing significant differences in performance, including detected CNV lengths and concordance, guiding more precise selections for specific research or clinical needs.