Peripheral membrane proteins in neurons, key for information transfer and transduction, are compartmentalized through unknown mechanisms; this study used probes with lipidation motifs and differently charged linkers expressed in Xenopus rod photoreceptors to investigate. Live imaging revealed variations in probe distribution based on lipid and charge, challenging previous ciliary enrichment models by demonstrating weak membrane binding and diffusion without needing chaperone proteins, suggesting a leaky cilium barrier facilitates a recycling enrichment process.
This journal is no longer published by Spirnger Narure. It is currently published by the Institute of Experimental Botany, Academy of Sciences of the Czech Republic.
Interesting article published in JCB. Research revealed that modifying mitochondrial dynamics—either by blocking fission or fusion—enhances this lifespan extension, independently of the mitochondrial unfolded protein response, and instead relies crucially on the transcription factor HLH-30/TFEB, highlighting a complex interplay between mitochondrial and lysosomal pathways in aging regulation.
Great article published in JCB. They revealed the importance of lineage context in defining neuronal subtypes and provide a demonstration of in vivo lineage-dependent induction of unique retinal neuron subtypes for treatment purposes.
Cyclin-dependent kinases CDK4/6 are shown to regulate lysosome numbers and biogenesis during the cell cycle, as their inactivation increases lysosomal counts by activating transcription factors TFEB and TFE3. These kinases interact with and phosphorylate TFEB/TFE3, controlling their location and activity, and affecting lysosome biogenesis by linking to the phases of the cell cycle, suggesting a new mechanism for managing lysosomal adaptation during cell division.
LINC complexes are essential transmembrane assemblies linking the nucleoskeleton and cytoskeleton, and their dysfunction is linked to diseases like cancer and muscular disorders. Research using FRET biosensors in cultured cells revealed that nesprin, a component of the LINC complex, detects tension from the cytoskeleton and regulates β-catenin signaling based on the extent of epithelial–mesenchymal transition, highlighting its role as a mechanotransducer.
We have published a perspective article relate to our Health Cafe program. This is the pdf link, it is a freely accessed article.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299132/pdf/40615_2020_Article_797.pdf
Annals of Tourism Research is a social sciences journal focusing upon the academic perspectives of tourism. While striving for a balance of theory and application, Annals is ultimately dedicated to developing theoretical constructs. Its strategies are to invite and encourage offerings from various disciplines; to serve as a forum through which these may interact; and thus to expand frontiers of knowledge in and contribute to the literature on tourism social science. In this role, Annals both structures and is structured by the research efforts of a multidisciplinary community of scholars.
One of the top journals in Sociology. As of 2023, Journal Citation Reports gives the journal a 2022 impact factor of 10.5, ranking it second out of 149 journals in the category "Sociology".
Interesting review article! This review explores CyPD’s potential as a therapeutic target for neurodegenerative disorders like Alzheimer’s and Parkinson’s, examining its regulation, interactions beyond the mPTP, and the development of specific inhibitors that could mitigate these conditions.
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