Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
出版年份 2013 全文链接
标题
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
作者
关键词
Non-parenchymal cells, Mechanisms of gene regulation, DILI, 3D Models, Cryopreservation, Clearance, Mathematical modeling
出版物
ARCHIVES OF TOXICOLOGY
Volume 87, Issue 8, Pages 1315-1530
出版商
Springer Nature
发表日期
2013-08-22
DOI
10.1007/s00204-013-1078-5
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- Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction
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- The Glycogen Synthase Kinase Inhibitor 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) Is a Partial Agonist of the Aryl Hydrocarbon Receptor
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- Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver
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- Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
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- Genome-wide association meta-analysis for total serum bilirubin levels
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- Reconstitution of the Death-Inducing Signaling Complex Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival
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- Quantitative Expression Profile of Hepatobiliary Transporters in Sandwich Cultured Rat and Human Hepatocytes
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- XIAP discriminates between type I and type II FAS-induced apoptosis
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- Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714
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- Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection
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- Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
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- Current Industrial Practices in Assessing CYP450 Enzyme Induction: Preclinical and Clinical
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- A review of drug patch testing and implications for HIV clinicians
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- Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model
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- HDAC family: What are the cancer relevant targets?
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- Long-Term Exposure to AZT, but not d4T, Increases Endothelial Cell Oxidative Stress and Mitochondrial Dysfunction
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- Establishment of Immortalized Human Hepatocytes by Introduction of HPV16 E6/E7 and hTERT as Cell Sources for Liver Cell-Based Therapy
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- Cell Lines: A Tool for In Vitro Drug Metabolism Studies
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- Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir
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- Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes
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- Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes
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- Dioxin Exposure, from Infancy through Puberty, Produces Endocrine Disruption and Affects Human Semen Quality
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- Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs
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- CD95 Ligand Is a Proliferative and Antiapoptotic Signal in Quiescent Hepatic Stellate Cells
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- The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers
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- ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes
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- Mechanism of T cell tolerance induction by murine hepatic Kupffer cells
- (2008) Qiang You et al. HEPATOLOGY
- Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function
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- High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
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- The stem cell niche of human livers: Symmetry between development and regeneration
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- Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide
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- The role of matrix stiffness in regulating cell behavior
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- Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes
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- Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response
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- Microencapsule technique protects hepatocytes from cryoinjury
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- Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity
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- Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors
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- The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2
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- Extracellular matrix dynamics in development and regenerative medicine
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- Tumor Necrosis Factor Is a Proximal Mediator of Synergistic Hepatotoxicity from Trovafloxacin/Lipopolysaccharide Coexposure
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