Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

(2011) Hartmut Jaeschke   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products

(2011) Hartmut Jaeschke et al.   LIFE SCIENCES

Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

(2011) Mary Lynn Bajt et al.   TOXICOLOGICAL SCIENCES

Secretory phospholipase A2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2

(2011) Vishakha S. Bhave et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

(2011) Anup Ramachandran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

(2010) Erik Norberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive Nitrogen Species in Acetaminophen-Induced Mitochondrial Damage and Toxicity in Mouse Hepatocytes

(2010) Angela S. Burke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity

(2010) B.K. Park et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pharmacogenomics in Drug Induced Liver Injury

(2010) Raul Andrade et al.   CURRENT DRUG METABOLISM

Involvement of the Immune System in Idiosyncratic Drug Reactions

(2010) Xiachu Zhang et al.   Drug Metabolism and Pharmacokinetics

Pathological aspects of lipid peroxidation

(2010) Anne Negre-Salvayre et al.   FREE RADICAL RESEARCH

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

(2010) Anup Ramachandran et al.   FREE RADICAL RESEARCH

Chemistry and biochemistry of lipid peroxidation products

(2010) F. Guéraud et al.   FREE RADICAL RESEARCH

Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury

(2010) M. Isabel Lucena et al.   HEPATOLOGY

Polymerase γ Gene POLG determines the risk of sodium valproate-induced liver toxicity

(2010) Joanna D. Stewart et al.   HEPATOLOGY

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells

(2010) Ana Blas-García et al.   HEPATOLOGY

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Silencing Glycogen Synthase Kinase-3β Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1

(2010) Mie Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase

(2010) R. Agarwal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice

(2010) Clarence David Williams et al.   LIVER INTERNATIONAL

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(2010) Daniel Antoine et al.   MOLECULAR MEDICINE

Lysosomal Iron Mobilization and Induction of the Mitochondrial Permeability Transition in Acetaminophen-Induced Toxicity to Mouse Hepatocytes

(2010) Kazuyoshi Kon et al.   TOXICOLOGICAL SCIENCES

The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes

(2010) Hui-Min Yan et al.   TOXICOLOGICAL SCIENCES

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES

Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury

(2010) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis

(2009) Cátia C.P. Aires et al.   BIOCHEMICAL PHARMACOLOGY

Carnitine in the treatment of valproic acid-induced toxicity

(2009) Philippe E.R. Lheureux et al.   CLINICAL TOXICOLOGY

Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

(2009) L. P. James et al.   DRUG METABOLISM AND DISPOSITION

Impairment of mitochondrial function by minocycline

(2009) Kathleen Kupsch et al.   FEBS Journal

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. against acetaminophen-induced toxicity in mice

(2009) Hai-Dan Yuan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Immunoallergic Drug-Induced Liver Injury in Humans

(2009) Jack Uetrecht   SEMINARS IN LIVER DISEASE

Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen

(2009) Kazunori Fujimoto et al.   TOXICOLOGIC PATHOLOGY

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

(2009) Rohini Kashimshetty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Inhibitory modulation of the mitochondrial permeability transition by minocycline

(2008) Anne Gieseler et al.   BIOCHEMICAL PHARMACOLOGY

Protective Effects of Salidroside against Acetaminophen-Induced Toxicity in Mice

(2008) Yan-Ling Wu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury

(2008) Akira Uchiyama et al.   HEPATOLOGY

Caspase activation is associated with spontaneous recovery from acute liver failure

(2008) Xandra Volkmann et al.   HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NIM811 (N-Methyl-4-isoleucine Cyclosporine), a Mitochondrial Permeability Transition Inhibitor, Attenuates Cholestatic Liver Injury but Not Fibrosis in Mice

(2008) H. Rehman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury

(2008) Cheng-chin Hsu et al.   PHYTOMEDICINE

Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A

(2008) Woen Ping Siu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: Effect on HMG-CoA synthase

(2008) Kelly K. Andringa et al.   TOXICOLOGY LETTERS

Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice

(2008) Ping-Guo Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY