Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

标题
Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam
作者
关键词
-
出版物
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 39, Issue 5, Pages 298-309
出版商
Elsevier BV
发表日期
2009-12-17
DOI
10.1016/j.ejps.2009.12.002

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