Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects

The effect of grapefruit juice on drug disposition

(2011) Michael J Hanley et al.   Expert Opinion on Drug Metabolism & Toxicology

Fruit juice inhibition of uptake transport: a new type of food-drug interaction

(2010) David G. Bailey   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren

(2010) Tuija Tapaninen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Grapefruit Juice Greatly Reduces the Plasma Concentrations of the OATP2B1 and CYP3A4 Substrate Aliskiren

(2010) T Tapaninen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patients with hypertension

(2009) Karl Andersen et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Clinical Pharmacokinetics and Pharmacodynamics of Aliskiren

(2008) Sujata Vaidyanathan et al.   CLINICAL PHARMACOKINETICS

Aliskiren Accumulates in Renin Secretory Granules and Binds Plasma Prorenin

(2008) Manne Krop et al.   HYPERTENSION

Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats

(2008) David L. Feldman et al.   HYPERTENSION

Pharmacokinetics of the Oral Direct Renin Inhibitor Aliskiren in Combination With Digoxin, Atorvastatin, and Ketoconazole in Healthy Subjects: The Role of P-Glycoprotein in the Disposition of Aliskiren

(2008) Sujata Vaidyanathan et al.   JOURNAL OF CLINICAL PHARMACOLOGY