Managing the challenge of chemically reactive metabolites in drug development

Mutant p53 rescue and modulation of p53 redox state

(2011) Vladimir J.N. Bykov et al.   CELL CYCLE

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

(2011) Tomasz Rzymski et al.   CELL CYCLE

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Involvement of natural killer T cells in halothane-induced liver injury in mice

(2010) Linling Cheng et al.   BIOCHEMICAL PHARMACOLOGY

Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis

(2010) Sidonie N. Lavergne et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Differential Regulation of Mitogen-Activated Protein Kinase Pathways by Acetaminophen and Its Nonhepatotoxic Regioisomer 3′-Hydroxyacetanilide in TAMH Cells

(2010) Brendan D. Stamper et al.   TOXICOLOGICAL SCIENCES

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES

Generation of T cell responses targeting the reactive metabolite of halothane in mice

(2010) Qiang You et al.   TOXICOLOGY LETTERS

Effect of bromfenac ophthalmic solution on ocular inflammation following cataract surgery

(2009) Masaru Miyanaga et al.   ACTA OPHTHALMOLOGICA

Fluorescence-Based Liver Microsomal Assay for Screening of Pharmaceutical Reactive Metabolites Using a Glutathione Conjugated 96-Well Plate

(2009) Xiang Ma et al.   BIOCONJUGATE CHEMISTRY

Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

(2009) Jonathon N. Bauman et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

(2009) Dennis A. Smith et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

(2009) S. Nakayama et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

(2009) T. Usui et al.   DRUG METABOLISM AND DISPOSITION

Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

(2009) J. Cheng et al.   DRUG METABOLISM AND DISPOSITION

Rapid Screening of Glutathione-Trapped Reactive Metabolites by Linear Ion Trap Mass Spectrometry with Isotope Pattern-Dependent Scanning and Postacquisition Data Mining

(2008) Li Ma et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparison of in Vitro Bioactivation of Flutamide and Its Cyano Analogue: Evidence for Reductive Activation by Human NADPH:Cytochrome P450 Reductase

(2008) Bo Wen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

(2008) R. Scott Obach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity

(2008) Dennis A. Smith et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Filling and mining the reactive metabolite target protein database

(2008) Robert P. Hanzlik et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Metabolic activation of carboxylic acids

(2008) Christian Skonberg et al.   Expert Opinion on Drug Metabolism & Toxicology

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

(2008) Ian M. Copple et al.   HEPATOLOGY

Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

(2008) Diana Chessman et al.   IMMUNITY

Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

(2007) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY

Protein Damage by Reactive Electrophiles: Targets and Consequences

(2007) Daniel C. Liebler   CHEMICAL RESEARCH IN TOXICOLOGY