Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer’s Disease

Herpes Simplex Virus Type I Induces an Incomplete Autophagic Response in Human Neuroblastoma Cells

(2018) Soraya Santana et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory and Neurodegeneration Markers during Asymptomatic HSV-1 Reactivation

(2018) Carolina Martin et al.   JOURNAL OF ALZHEIMERS DISEASE

Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation

(2017) Soichiro Kakuta et al.   FASEB JOURNAL

Herpes simplex virus type 1 and Alzheimer’s disease: possible mechanisms and signposts

(2017) Ruth F. Itzhaki   FASEB JOURNAL

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

(2017) Alexis E. González et al.   FASEB JOURNAL

Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation

(2017) Hai-Bin Ruan et al.   GENES & DEVELOPMENT

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease

(2017) Stuart D. Portbury et al.   JOURNAL OF ALZHEIMERS DISEASE

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1

(2017) Yingli He et al.   JOURNAL OF CELL BIOLOGY

Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress

(2017) Elizabeth I. Vink et al.   JOURNAL OF VIROLOGY

Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation

(2017) Kefeng Lu et al.   NATURE CELL BIOLOGY

ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease

(2017) Bo-Jeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

(2017) Yong Tae Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

(2017) Xuan Li et al.   Nature Communications

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

(2017) YouJin Lee et al.   Cell Reports

Reversible phosphorylation of the 26S proteasome

(2017) Xing Guo et al.   Protein & Cell

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   eLife

C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease

(2017) María-Salud García-Ayllón et al.   Scientific Reports

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation

(2016) Gayathri Swaminathan et al.   Autophagy

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

(2016) Roland Hjerpe et al.   CELL

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

The recognition of ubiquitinated proteins by the proteasome

(2016) Guinevere L. Grice et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

(2016) Daichao Xu et al.   GENES & DEVELOPMENT

The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

(2016) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration

(2016) Wei Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons

(2016) Sarah Katzenell et al.   JOURNAL OF VIROLOGY

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

(2016) Krisztina Hegedűs et al.   MOLECULAR BIOLOGY OF THE CELL

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval

(2016) Timothy J. Jarome et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease

(2016) Antonella Tramutola et al.   Oxidative Medicine and Cellular Longevity

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

(2016) Y. Shi et al.   SCIENCE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

(2016) Jianbin Zhang et al.   Oncotarget

ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

(2016) Ryuji Oshima et al.   Scientific Reports

Identification of Differentially Expressed Genes through Integrated Study of Alzheimer’s Disease Affected Brain Regions

(2016) Nisha Puthiyedth et al.   PLoS One

Neurotropic virus infections as the cause of immediate and delayed neuropathology

(2015) Martin Ludlow et al.   ACTA NEUROPATHOLOGICA

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy

(2015) Stefan Drießen et al.   Autophagy

Chaperone-mediated 26S Proteasome Remodeling Facilitates Free K63 Ubiquitin Chain Production and Aggresome Clearance

(2015) Priyaanka Nanduri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

(2015) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

(2015) S Kim et al.   MOLECULAR PSYCHIATRY

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis

(2015) Xing Guo et al.   NATURE CELL BIOLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Protein Expression of Proteasome Subunits in Elderly Patients with Schizophrenia

(2015) Madeline R Scott et al.   NEUROPSYCHOPHARMACOLOGY

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

(2015) Swetha Gowrishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection

(2015) Luis Leyton et al.   VIRUS RESEARCH

c-Abl Regulates Proteasome Abundance by Controlling the Ubiquitin-Proteasomal Degradation of PSMA7 Subunit

(2015) Dapei Li et al.   Cell Reports

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy

(2015) Bettina Wurzer et al.   eLife

Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy

(2015) Viviana A. Cavieres et al.   PLoS One

Phosphorylation of NBR1 by GSK3 modulates protein aggregation

(2014) Anne-Sophie Nicot et al.   Autophagy

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding

(2014) Frank Christian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ubiquilin gene family: evolutionary patterns and functional insights

(2014) Ignacio Marín   BMC EVOLUTIONARY BIOLOGY

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

(2014) Seung-Hyun Ro et al.   FEBS Journal

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

(2014) Yanying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Proteostasis and the Aging Proteome in Health and Disease

(2014) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Nrf2, a Regulator of the Proteasome, Controls Self-Renewal and Pluripotency in Human Embryonic Stem Cells

(2014) Jiwon Jang et al.   STEM CELLS

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

(2014) Mingming Zhang et al.   Scientific Reports

The proteasome and the degradation of oxidized proteins: Part III—Redox regulation of the proteasomal system

(2014) Tobias Jung et al.   Redox Biology

Structural Biology of the Proteasome

(2013) Erik Kish-Trier et al.   Annual Review of Biophysics

Regulation of proteasome activity in health and disease

(2013) Marion Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

HDAC6 mediates the acetylation of TRIM50

(2013) Carmela Fusco et al.   CELLULAR SIGNALLING

Interaction Domains of p62: A Bridge Between p62 and Selective Autophagy

(2013) Xiaolong Lin et al.   DNA AND CELL BIOLOGY

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

(2013) Khushbu K Patel et al.   EMBO JOURNAL

Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery

(2013) Dong Yun Lee et al.   EMBO REPORTS

Autophagy and cell death

(2013) Tohru Yonekawa et al.   Essays in Biochemistry

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond

(2013) Ziyou Cui et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice

(2013) Jing Du et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains

(2013) Rui Hao et al.   MOLECULAR CELL

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Turnover of C99 is Controlled by a Crosstalk between ERAD and Ubiquitin-Independent Lysosomal Degradation in Human Neuroglioma Cells

(2013) Hianara A. Bustamante et al.   PLoS One

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

(2012) Lyndsay Murrow et al.   Annual Review of Pathology-Mechanisms of Disease

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy

(2012) E Keil et al.   CELL DEATH AND DIFFERENTIATION

HSV, axonal transport and Alzheimer’s disease:in vitroandin vivoevidence for causal relationships

(2012) Elaine L Bearer   Future Virology

Enhanced  -secretase processing alters APP axonal transport and leads to axonal defects

(2012) E. M. Rodrigues et al.   HUMAN MOLECULAR GENETICS

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

(2012) Yogikala Prabhu et al.   MOLECULAR BIOLOGY OF THE CELL

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688

(2012) A. El Ayadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

(2011) Utano Tomaru et al.   AMERICAN JOURNAL OF PATHOLOGY

The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes

(2011) Qun Lu et al.   DEVELOPMENTAL CELL

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein

(2011) Emily S. Stieren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1

(2011) Mingming Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells

(2011) Soraya Santana et al.   NEUROBIOLOGY OF AGING

Herpes Simplex Virus Dances with Amyloid Precursor Protein while Exiting the Cell

(2011) Shi-Bin Cheng et al.   PLoS One

Activity Dependent Protein Degradation Is Critical for the Formation and Stability of Fear Memory in the Amygdala

(2011) Timothy J. Jarome et al.   PLoS One

Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing

(2011) N C Inestrosa et al.   Translational Psychiatry

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Ubiquilin at a crossroads in protein degradation pathways

(2010) Cara Rothenberg et al.   Autophagy

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

(2010) Patricia V. Burgos et al.   DEVELOPMENTAL CELL

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication

(2010) U. Chuluunbaatar et al.   GENES & DEVELOPMENT

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

(2010) C. Rothenberg et al.   HUMAN MOLECULAR GENETICS

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osmotic Stress Inhibits Proteasome by p38 MAPK-dependent Phosphorylation

(2010) Seung-Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Exit from the Golgi Is Required for the Expansion of the Autophagosomal Phagophore in Yeast Saccharomyces cerevisiae

(2010) Aniek van der Vaart et al.   MOLECULAR BIOLOGY OF THE CELL

ATP-Dependent Steps in the Binding of Ubiquitin Conjugates to the 26S Proteasome that Commit to Degradation

(2010) Andreas Peth et al.   MOLECULAR CELL

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

Heterohexameric Ring Arrangement of the Eukaryotic Proteasomal ATPases: Implications for Proteasome Structure and Assembly

(2010) Robert J. Tomko et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives

(2010) Nikolaos K. Robakis   NEUROBIOLOGY OF AGING

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagosome Formation Depends on the Small GTPase Rab1 and Functional ER Exit Sites

(2010) Felipe Carlos Martín Zoppino et al.   TRAFFIC

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Intracellular Aβ and C99 aggregates induce mitochondria-dependent cell death in human neuroglioma H4 cells through recruitment of the 20S proteasome subunits

(2009) Hyo-Jin Park et al.   BRAIN RESEARCH

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation

(2009) Elsa-Noah N'Diaye et al.   EMBO REPORTS

Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover

(2009) Sarah Waters et al.   FEBS LETTERS

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Regulation of the Proteasome by Neuronal Activity and Calcium/Calmodulin-dependent Protein Kinase II

(2009) Stevan N. Djakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Herpes simplex type I (HSV-1) infection of the nervous system: Is an immune response a good thing?

(2009) Christopher D. Conrady et al.   JOURNAL OF NEUROIMMUNOLOGY

Interaction of ICP34.5 with Beclin 1 Modulates Herpes Simplex Virus Type 1 Pathogenesis through Control of CD4+ T-Cell Responses

(2009) D. A. Leib et al.   JOURNAL OF VIROLOGY

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alzheimer's-related endosome dysfunction in Down syndrome is A -independent but requires APP and is reversed by BACE-1 inhibition

(2009) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

(2009) V. I. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herp enhances ER-associated protein degradation by recruiting ubiquilins

(2008) Tae-Yeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION

Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease

(2008) Yi Li et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts

(2008) Mitsutoshi Asai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Primary target cells of herpes simplex virus type 1 in the hippocampus

(2008) Yoshinori Ando et al.   MICROBES AND INFECTION

Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

(2008) Julius Rabl et al.   MOLECULAR CELL

Proteasome subunit Rpn13 is a novel ubiquitin receptor

(2008) Koraljka Husnjak et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

(2007) Bertrand P. Tseng et al.   NEUROBIOLOGY OF AGING