Reversible phosphorylation of the 26S proteasome

Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G

(2016) Peter P. Rainer et al.   CARDIOVASCULAR RESEARCH

The 26S proteasome: A cell cycle regulator regulated by cell cycle

(2016) Xing Guo et al.   CELL CYCLE

The life cycle of the 26S proteasome: from birth, through regulation and function and onto its death

(2016) Ido Livneh et al.   CELL RESEARCH

Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics

(2016) Grace R. Williams et al.   METHODS

Ramping up degradation for proliferation

(2016) Jon M. Huibregtse et al.   NATURE CELL BIOLOGY

Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder

(2016) Yangyang Bian et al.   Nature Chemical Biology

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval

(2016) Timothy J. Jarome et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Structural basis for dynamic regulation of the human 26S proteasome

(2016) Shuobing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

(2016) Y. Shi et al.   SCIENCE

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome

(2016) Jing Li et al.   Science Signaling

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome

(2016) Jing Li et al.   Science Signaling

Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29

(2016) Prashant S. Wani et al.   Scientific Reports

Quantitative analysis of a phosphoproteome readily altered by the protein kinase CK2 inhibitor quinalizarin in HEK-293T cells

(2015) Cinzia Franchin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase

(2015) Yantao He et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation

(2015) Stephen Rush Fuhs et al.   CELL

A Mass Spectrometry Platform for a Streamlined Investigation of Proteasome Integrity, Posttranslational Modifications, and Inhibitor Binding

(2015) Malte Gersch et al.   CHEMISTRY & BIOLOGY

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis

(2015) Xing Guo et al.   NATURE CELL BIOLOGY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate degradation by the proteasome: A single-molecule kinetic analysis

(2015) Y. Lu et al.   SCIENCE

A molecular census of 26S proteasomes in intact neurons

(2015) S. Asano et al.   SCIENCE

Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics

(2015) Chia-Feng Tsai et al.   Nature Communications

c-Abl Regulates Proteasome Abundance by Controlling the Ubiquitin-Proteasomal Degradation of PSMA7 Subunit

(2015) Dapei Li et al.   Cell Reports

Global discovery of high-NaCl-induced changes of protein phosphorylation

(2014) Rong Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Characterization of the Testis-specific Proteasome Subunit α4s in Mammals

(2014) Hiroyuki Uechi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

(2014) Philipp Mertins et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure of the Rpn11–Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation

(2014) Evan J Worden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome

(2014) P. Unverdorben et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

(2014) Conor J Howard et al.   eLife

Structural Insights into Proteasome Activation by the 19S Regulatory Particle

(2013) Aaron Ehlinger et al.   BIOCHEMISTRY

Regulation of proteasome activity in health and disease

(2013) Marion Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel role of proteasomal β1 subunit in tumorigenesis

(2013) Fuqiang Yuan et al.   BIOSCIENCE REPORTS

A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells

(2013) Fabio Petrocca et al.   CANCER CELL

PKG Primes the Proteasome

(2013) Thomas G. Gillette et al.   CIRCULATION

Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins

(2013) Mark J. Ranek et al.   CIRCULATION

Ubiquitinated Proteins Activate the Proteasomal ATPases by Binding to Usp14 or Uch37 Homologs

(2013) Andreas Peth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond

(2013) Ziyou Cui et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

(2013) Florian Gnad et al.   MOLECULAR & CELLULAR PROTEOMICS

Arginine Methylation Initiates BMP-Induced Smad Signaling

(2013) Jian Xu et al.   MOLECULAR CELL

Conformational switching of the 26S proteasome enables substrate degradation

(2013) Mary E Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of  -Adrenergic Receptor Signaling

(2013) A. Lundby et al.   Science Signaling

Post-translational modification of cardiac proteasomes: functional delineation enabled by proteomics

(2012) Sarah B. Scruggs et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia

(2012) M. Trost et al.   BLOOD

Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors

(2012) Y. Bai et al.   CANCER RESEARCH

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control

(2012) Walter Becker   CELL CYCLE

Phosphorylation of Rpt6 Regulates Synaptic Strength in Hippocampal Neurons

(2012) S. N. Djakovic et al.   JOURNAL OF NEUROSCIENCE

Molecular Characterization of EGFR and EGFRvIII Signaling Networks in Human Glioblastoma Tumor Xenografts

(2012) Hannah Johnson et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Phosphoproteomic Analysis Reveals a Role for Serine and Threonine Kinases in the Cytoskeletal Reorganization in Early T Cell Receptor Activation in Human Primary T Cells

(2012) Patricia Ruperez et al.   MOLECULAR & CELLULAR PROTEOMICS

Investigation of Receptor interacting protein (RIP3)-dependent Protein Phosphorylation by Quantitative Phosphoproteomics

(2012) Xiurong Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways

(2012) Koshi Imami et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease

(2012) J.-T. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Activity-Dependent Growth of New Dendritic Spines Is Regulated by the Proteasome

(2012) Andrew M. Hamilton et al.   NEURON

cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons

(2012) Natura Myeku et al.   NEUROSCIENCE LETTERS

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

(2012) J. M. Drake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative phosphoproteomic analysis of neonatal and adult murine brain

(2012) Tapasree Goswami et al.   PROTEOMICS

Calcineurin stimulates the expression of inflammatory factors in RAW 264.7 cells by interacting with proteasome subunit alpha type 6

(2011) Wen Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcineurin B subunit interacts with proteasome subunit alpha type 7 and represses hypoxia-inducible factor-1α activity via the proteasome pathway

(2011) Ning Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System

(2011) Tsui-Fen Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome Activators

(2011) Beth M. Stadtmueller et al.   MOLECULAR CELL

A large-scale method to measure absolute protein phosphorylation stoichiometries

(2011) Ronghu Wu et al.   NATURE METHODS

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease

(2011) Baris Bingol et al.   NEURON

Keeping proteasomes under control--a role for phosphorylation in the nucleus

(2011) Z. Sha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity

(2011) X. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Quantitative proteome analysis of the 20S proteasome of apoptotic Jurkat T cells

(2010) Frank Schmidt et al.   AMINO ACIDS

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo

(2010) Shuangxi Wang et al.   CIRCULATION RESEARCH

ASK1 Negatively Regulates the 26 S Proteasome

(2010) Ji Won Um et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osmotic Stress Inhibits Proteasome by p38 MAPK-dependent Phosphorylation

(2010) Seung-Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In-depth Analyses of Kinase-dependent Tyrosine Phosphoproteomes Based on Metal Ion-functionalized Soluble Nanopolymers

(2010) Anton B. Iliuk et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Site-specific Phosphorylation Dynamics of Human Protein Kinases during Mitotic Progression

(2010) Kalyan Dulla et al.   MOLECULAR & CELLULAR PROTEOMICS

The phosphoproteome of toll-like receptor-activated macrophages

(2010) Gabriele Weintz et al.   Molecular Systems Biology

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Co- and post-translational modifications of the 26S proteasome in yeast

(2010) Julia Kikuchi et al.   PROTEOMICS

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Multiple Assembly Chaperones Govern Biogenesis of the Proteasome Regulatory Particle Base

(2009) Minoru Funakoshi et al.   CELL

Assembly Pathway of the Mammalian Proteasome Base Subcomplex Is Mediated by Multiple Specific Chaperones

(2009) Takeumi Kaneko et al.   CELL

Phosphoproteomic Analysis of Human Embryonic Stem Cells

(2009) Laurence M. Brill et al.   Cell Stem Cell

Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions

(2009) Yadong Yu et al.   EMBO JOURNAL

Characterization and differential expression of a newly identified phosphorylated isoform of the human 20S proteasome β7 subunit in tumor vs. normal cell lines

(2009) Rothmony Eang et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Regulation of the Proteasome by Neuronal Activity and Calcium/Calmodulin-dependent Protein Kinase II

(2009) Stevan N. Djakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

‘Two-Stage Double-Technique Hybrid (TSDTH)’ Identification Strategy for the Analysis of BMP2-Induced Transdifferentiation of Premyoblast C2C12 Cells to Osteoblast

(2009) Byung-Gyu Kim et al.   JOURNAL OF PROTEOME RESEARCH

Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics

(2009) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure and Activity of the N-Terminal Substrate Recognition Domains in Proteasomal ATPases

(2009) Sergej Djuranovic et al.   MOLECULAR CELL

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

(2009) Chunaram Choudhary et al.   MOLECULAR CELL

Chaperone-mediated pathway of proteasome regulatory particle assembly

(2009) Jeroen Roelofs et al.   NATURE

Hexameric assembly of the proteasomal ATPases is templated through their C termini

(2009) Soyeon Park et al.   NATURE

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment

(2009) Kohji Nagano et al.   PROTEOMICS

Positive Selection of Tyrosine Loss in Metazoan Evolution

(2009) C. S. H. Tan et al.   SCIENCE

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

Role of AMP-activated protein kinase in autophagy and proteasome function

(2008) Rosa Viana et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

(2008) Daniel Moreno et al.   FEBS LETTERS

PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts

(2008) Mitsutoshi Asai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Global Impact of Oncogenic Src on a Phosphotyrosine Proteome

(2008) Weifeng Luo et al.   JOURNAL OF PROTEOME RESEARCH

Revealing the Dynamics of the 20 S Proteasome Phosphoproteome

(2008) Haojie Lu et al.   MOLECULAR & CELLULAR PROTEOMICS

Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

(2008) Julius Rabl et al.   MOLECULAR CELL

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

(2008) Patrick Schreiner et al.   NATURE

Proteasome subunit Rpn13 is a novel ubiquitin receptor

(2008) Koraljka Husnjak et al.   NATURE

Signaling networks assembled by oncogenic EGFR and c-Met

(2008) A. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA