The role of protein clearance mechanisms in organismal ageing and age-related diseases
出版年份 2014 全文链接
标题
The role of protein clearance mechanisms in organismal ageing and age-related diseases
作者
关键词
-
出版物
Nature Communications
Volume 5, Issue 1, Pages -
出版商
Springer Nature
发表日期
2014-12-08
DOI
10.1038/ncomms6659
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Enhancing protein disaggregation restores proteasome activity in aged cells
- (2016) Veronica Andersson et al. Aging-US
- Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
- (2014) Anne Simonsen et al. Autophagy
- A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy
- (2014) Randy Singh Atwal et al. Autophagy
- Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans
- (2014) Márton L. Tóth et al. Autophagy
- Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells
- (2014) Chuankai Zhou et al. CELL
- The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
- (2014) Isabel Saez et al. CURRENT GENOMICS
- The nematode Caenorhabditis elegans: A versatile model for the study of proteotoxicity and aging
- (2014) Yuli Volovik et al. METHODS
- Germline stem cell arrest inhibits the collapse of somatic proteostasis early inCaenorhabditis elegansadulthood
- (2013) Netta Shemesh et al. AGING CELL
- FOXO4 is necessary for neural differentiation of human embryonic stem cells
- (2013) David Vilchez et al. AGING CELL
- Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy
- (2013) Keiji Tanaka et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Regulation of proteasome activity in health and disease
- (2013) Marion Schmidt et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Mechanisms that Regulate Stem Cell Aging and Life Span
- (2013) Robert A.J. Signer et al. Cell Stem Cell
- Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress
- (2013) Eleni N. Tsakiri et al. FASEB JOURNAL
- IGF-1 receptor antagonism inhibits autophagy
- (2013) Maurizio Renna et al. HUMAN MOLECULAR GENETICS
- Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
- (2013) Laura J. Blair et al. JOURNAL OF CLINICAL INVESTIGATION
- DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance
- (2013) Maria A. Ermolaeva et al. NATURE
- FOXO3A directs a protective autophagy program in haematopoietic stem cells
- (2013) Matthew R. Warr et al. NATURE
- MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
- (2013) Eyleen J. O’Rourke et al. NATURE CELL BIOLOGY
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- FIP200 is required for maintenance and differentiation of postnatal neural stem cells
- (2013) Chenran Wang et al. NATURE NEUROSCIENCE
- FOXOs: signalling integrators for homeostasis maintenance
- (2013) Astrid Eijkelenboom et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- REG deficiency promotes premature aging via the casein kinase 1 pathway
- (2013) L. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system
- (2013) Min Jae Lee et al. PROGRESS IN NEUROBIOLOGY
- Proteostasis and aging of stem cells
- (2013) David Vilchez et al. TRENDS IN CELL BIOLOGY
- Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28
- (2013) Malin Hernebring et al. Scientific Reports
- Insulin/IGF-1 Signaling Regulates Proteasome Activity through the Deubiquitinating Enzyme UBH-4
- (2013) Olli Matilainen et al. Cell Reports
- The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
- (2013) Tobias Jung et al. Redox Biology
- Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster
- (2012) Åsa Fredriksson et al. AGING CELL
- Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System
- (2012) Shannon M. Buckley et al. Cell Stem Cell
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
- (2012) Adriana Sánchez-Danés et al. EMBO Molecular Medicine
- Motor Neuron-specific Disruption of Proteasomes, but Not Autophagy, Replicates Amyotrophic Lateral Sclerosis
- (2012) Yoshitaka Tashiro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Indirect inhibition of 26S proteasome activity in a cellular model of Huntington’s disease
- (2012) Mark S. Hipp et al. JOURNAL OF CELL BIOLOGY
- Testing Predictions of the Oxidative Stress Hypothesis of Aging Using a Novel Invertebrate Model of Longevity: The Giant Clam (Tridacna Derasa)
- (2012) Z. Ungvari et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Increased proteasome activity in human embryonic stem cells is regulated by PSMD11
- (2012) David Vilchez et al. NATURE
- RPN-6 determines C. elegans longevity under proteotoxic stress conditions
- (2012) David Vilchez et al. NATURE
- A Putative Role for the Immunoproteasome in the Maintenance of Pluripotency in Human Embryonic Stem Cells
- (2012) Stuart P. Atkinson et al. STEM CELLS
- Basal Autophagy Decreased During the Differentiation of Human Adult Mesenchymal Stem Cells
- (2012) Lisa Oliver et al. STEM CELLS AND DEVELOPMENT
- Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities
- (2011) Utano Tomaru et al. AMERICAN JOURNAL OF PATHOLOGY
- The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
- (2011) Dan Egan et al. Autophagy
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Autophagy is required for self-renewal and differentiation of adult human stem cells
- (2011) Souzan Salemi et al. CELL RESEARCH
- Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans
- (2011) Louis R. Lapierre et al. CURRENT BIOLOGY
- EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan
- (2011) Gang Liu et al. EMBO JOURNAL
- Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism
- (2011) Thomas Dange et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteasome Activators
- (2011) Beth M. Stadtmueller et al. MOLECULAR CELL
- Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
- (2011) Mohamed Elgendy et al. MOLECULAR CELL
- Molecular chaperones in protein folding and proteostasis
- (2011) F. Ulrich Hartl et al. NATURE
- Autophagy in Human Embryonic Stem Cells
- (2011) Thien Tra et al. PLoS One
- The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together
- (2011) G. R. Pathare et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- Alzheimer's Disease
- (2011) D. J. Selkoe Cold Spring Harbor Perspectives in Biology
- Proteostasis and Movement Disorders: Parkinson's Disease and Amyotrophic Lateral Sclerosis
- (2011) D. A. Bosco et al. Cold Spring Harbor Perspectives in Biology
- Aging as an Event of Proteostasis Collapse
- (2011) R. C. Taylor et al. Cold Spring Harbor Perspectives in Biology
- Huntington's Disease
- (2011) S. Finkbeiner Cold Spring Harbor Perspectives in Biology
- Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae
- (2011) Undine Kruegel et al. PLoS Genetics
- A pathway that links reproductive status to lifespan in Caenorhabditis elegans
- (2010) Cynthia Kenyon Annals of the New York Academy of Sciences
- Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions
- (2010) Tilman Grune et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis
- (2010) Beatriz Caramés et al. ARTHRITIS AND RHEUMATISM
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
- (2010) Pankaj Kapahi et al. Cell Metabolism
- Growth hormone, insulin and aging: The benefits of endocrine defects
- (2010) Andrzej Bartke EXPERIMENTAL GERONTOLOGY
- Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
- (2010) I. Irrcher et al. HUMAN MOLECULAR GENETICS
- Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts
- (2010) Suzanne Kapeta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor for neurodegenerative disorders
- (2010) Claus Zabel et al. Journal of Proteomics
- skn - 1 -Dependent and -Independent Regulation of aip - 1 Expression following Metabolic Stress in Caenorhabditis elegans
- (2010) Annabel A. Ferguson et al. MOLECULAR AND CELLULAR BIOLOGY
- Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes
- (2010) Nobumichi Furuta et al. MOLECULAR BIOLOGY OF THE CELL
- The genetics of ageing
- (2010) Cynthia J. Kenyon NATURE
- Autophagy in mammalian development and differentiation
- (2010) Noboru Mizushima et al. NATURE CELL BIOLOGY
- A photoconvertible reporter of the ubiquitin-proteasome system in vivo
- (2010) Geert Hamer et al. NATURE METHODS
- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
- (2010) Marta Martinez-Vicente et al. NATURE NEUROSCIENCE
- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
- (2010) M. M. Lipinski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- Integration of Clearance Mechanisms: The Proteasome and Autophagy
- (2010) E. Wong et al. Cold Spring Harbor Perspectives in Biology
- A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors
- (2010) Mirela Matecic et al. PLoS Genetics
- Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
- (2009) Evan T. Powers et al. Annual Review of Biochemistry
- Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome
- (2009) Daniel Finley Annual Review of Biochemistry
- Regulation Mechanisms and Signaling Pathways of Autophagy
- (2009) Congcong He et al. Annual Review of Genetics
- A gene expression signature shared by human mature oocytes and embryonic stem cells
- (2009) Said Assou et al. BMC GENOMICS
- Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice
- (2009) Ehud Cohen et al. CELL
- 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
- (2009) Brian M. Zid et al. CELL
- Autophagy Suppresses Tumorigenesis through Elimination of p62
- (2009) Robin Mathew et al. CELL
- Autophagy mediates the mitotic senescence transition
- (2009) A. R.J. Young et al. GENES & DEVELOPMENT
- The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging – A Mini-Review
- (2009) Stuart K. Calderwood et al. GERONTOLOGY
- AIP-1 ameliorates β-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model
- (2009) Wail M. Hassan et al. HUMAN MOLECULAR GENETICS
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat
- (2009) V. I. Perez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association ofFOXO3Avariation with human longevity confirmed in German centenarians
- (2009) Friederike Flachsbart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Signals of youth: endocrine regulation of aging in Caenorhabditis elegans
- (2009) Siler H. Panowski et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Chaperone-mediated autophagy: selectivity pays off
- (2009) Ana Maria Cuervo TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Control of autophagy by oncogenes and tumor suppressor genes
- (2008) M C Maiuri et al. CELL DEATH AND DIFFERENTIATION
- Proteasome activation as a novel antiaging strategy
- (2008) Niki Chondrogianni et al. IUBMB LIFE
- Proteasomes Cleave at Multiple Sites within Polyglutamine Tracts
- (2008) Gregory Pratt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
- (2008) Tereza Vogiatzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson’s disease patients
- (2008) Claudia Wahl et al. JOURNAL OF NEURAL TRANSMISSION
- Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
- (2008) Edward D. Plowey et al. JOURNAL OF NEUROCHEMISTRY
- Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies
- (2008) L. Bedford et al. JOURNAL OF NEUROSCIENCE
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process
- (2008) A. Tonoki et al. MOLECULAR AND CELLULAR BIOLOGY
- The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane
- (2008) U. Bandyopadhyay et al. MOLECULAR AND CELLULAR BIOLOGY
- CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control
- (2008) J.-N. Min et al. MOLECULAR AND CELLULAR BIOLOGY
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
- (2008) Cong Zhang et al. NATURE MEDICINE
- The insulin paradox: aging, proteotoxicity and neurodegeneration
- (2008) Ehud Cohen et al. NATURE REVIEWS NEUROSCIENCE
- How to Live Long and Prosper: Autophagy, Mitochondria, and Aging
- (2008) Wei-Lien Yen et al. PHYSIOLOGY
- A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
- (2008) Malene Hansen et al. PLoS Genetics
- Akt and CHIP coregulate tau degradation through coordinated interactions
- (2008) C. A. Dickey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective benefits of damage partitioning in unicellular systems and its effects on aging
- (2008) N. Erjavec et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
- (2008) I. H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans
- (2008) C. Yun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functionally significant insulin-like growth factor I receptor mutations in centenarians
- (2008) Y. Suh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Ubiquitin-Proteasome Pathway in Huntington's Disease
- (2008) Siddhartha Mitra et al. TheScientificWorldJOURNAL
- Autophagy and aging: keeping that old broom working
- (2008) Ana Maria Cuervo TRENDS IN GENETICS
- Aβ inhibits the proteasome and enhances amyloid and tau accumulation
- (2007) Bertrand P. Tseng et al. NEUROBIOLOGY OF AGING
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