Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
出版年份 2017 全文链接
标题
Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
作者
关键词
-
出版物
eLife
Volume 6, Issue -, Pages -
出版商
eLife Sciences Organisation, Ltd.
发表日期
2017-01-14
DOI
10.7554/elife.21776
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Amyloid-β Secretion, Generation, and Lysosomal Sequestration in Response to Proteasome Inhibition: Involvement of Autophagy
- (2018) Lotta Agholme et al. JOURNAL OF ALZHEIMERS DISEASE
- Compartment-Specific Regulation of Autophagy in Primary Neurons
- (2016) Sandra Maday et al. JOURNAL OF NEUROSCIENCE
- The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes
- (2016) Zheng Wang et al. MOLECULAR CELL
- Axonal autophagosomes use the ride-on service for retrograde transport toward the soma
- (2015) Xiu-Tang Cheng et al. Autophagy
- Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes
- (2015) Xiu-Tang Cheng et al. JOURNAL OF CELL BIOLOGY
- Autophagosome dynamics in neurodegeneration at a glance
- (2015) Y. C. Wong et al. JOURNAL OF CELL SCIENCE
- Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice
- (2015) Yuxiang Xie et al. NEURON
- Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a
- (2015) Yoosoo Yang et al. Cell Reports
- Autophagy and human disease: emerging themes
- (2014) Jaime L Schneider et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes
- (2014) Meng-meng Fu et al. DEVELOPMENTAL CELL
- Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway
- (2014) Sandra Maday et al. DEVELOPMENTAL CELL
- Mitochondrial trafficking and anchoring in neurons: New insight and implications
- (2014) Zu-Hang Sheng JOURNAL OF CELL BIOLOGY
- O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation
- (2014) Bin Guo et al. NATURE CELL BIOLOGY
- The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease
- (2014) Tara L. Spires-Jones et al. NEURON
- Snapin-Mediated BACE1 Retrograde Transport Is Essential for Its Degradation in Lysosomes and Regulation of APP Processing in Neurons
- (2014) Xuan Ye et al. Cell Reports
- Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport
- (2013) Yanmin Chen et al. JOURNAL OF CELL BIOLOGY
- Amyloid- Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3 in Primary Cultured Hippocampal Neurons
- (2013) H. Decker et al. JOURNAL OF NEUROSCIENCE
- Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice
- (2013) A. H. Nagahara et al. JOURNAL OF NEUROSCIENCE
- Long-distance Axonal Transport of AAV9 Is Driven by Dynein and Kinesin-2 and Is Trafficked in a Highly Motile Rab7-positive Compartment
- (2013) Michael J Castle et al. MOLECULAR THERAPY
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity
- (2013) Luisa Diomede et al. NEUROBIOLOGY OF DISEASE
- Accumulation of Intraneuronal β-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses
- (2013) Reisuke H. Takahashi et al. PLoS One
- Guidelines for the use and interpretation of assays for monitoring autophagy
- (2012) Daniel J. Klionsky et al. Autophagy
- The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes
- (2012) Eisuke Itakura et al. CELL
- Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons
- (2012) Qian Cai et al. CURRENT BIOLOGY
- Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases
- (2012) Raquel de Pablo-Latorre et al. HUMAN MOLECULAR GENETICS
- Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
- (2012) Sandra Maday et al. JOURNAL OF CELL BIOLOGY
- Early and Selective Impairments in Axonal Transport Kinetics of Synaptic Cargoes Induced by Soluble Amyloid β-Protein Oligomers
- (2012) Yong Tang et al. TRAFFIC
- Snapin Recruits Dynein to BDNF-TrkB Signaling Endosomes for Retrograde Axonal Transport and Is Essential for Dendrite Growth of Cortical Neurons
- (2012) Bing Zhou et al. Cell Reports
- Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
- (2011) Dun-Sheng Yang et al. Autophagy
- Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy
- (2011) SooYeon Lee et al. Autophagy
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model
- (2011) Sebastian Jimenez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy
- (2011) S. Lee et al. JOURNAL OF NEUROSCIENCE
- Autophagy failure in Alzheimer's disease—locating the primary defect
- (2011) Ralph A. Nixon et al. NEUROBIOLOGY OF DISEASE
- A Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines
- (2010) H. Zempel et al. JOURNAL OF NEUROSCIENCE
- Cell “Self-Eating” (Autophagy) Mechanism in Alzheimer's Disease
- (2010) Sarah F. Funderburk et al. MOUNT SINAI JOURNAL OF MEDICINE
- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
- (2010) Marta Martinez-Vicente et al. NATURE NEUROSCIENCE
- Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons
- (2010) Qian Cai et al. NEURON
- A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
- (2010) A. S. Tsvetkov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
- (2010) H. Du et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1
- (2010) Keith A. Vossel et al. SCIENCE
- The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases
- (2009) Zhenyu Yue et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- β-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure
- (2009) Jorge Parodi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Cleavage Products of Amyloid- Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites
- (2009) V. Muresan et al. JOURNAL OF NEUROSCIENCE
- GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis
- (2009) Renata Sano et al. MOLECULAR CELL
- Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta
- (2009) G. Pigino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation
- (2008) Jian-Sheng Kang et al. CELL
- Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic
- (2008) S. Jimenez et al. JOURNAL OF NEUROSCIENCE
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Role of Endoplasmic Reticulum, Endosomal-Lysosomal Compartments, and Microtubules in Amyloid Precursor Protein Metabolism of Human Neurons
- (2003) Andréa C. LeBlanc et al. JOURNAL OF NEUROCHEMISTRY
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