Regulating Rho GTPases and their regulators

Fbxw7 regulates tumor apoptosis, growth arrest and the epithelial-to-mesenchymal transition in part through the RhoA signaling pathway in gastric cancer

(2016) Hui Li et al.   CANCER LETTERS

Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1

(2016) Michelle C. Helms et al.   CELLULAR SIGNALLING

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

(2016) Hadir Marei et al.   Nature Communications

Tensin1 positively regulates RhoA activity through its interaction with DLC1

(2015) Yi-Ping Shih et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SND1 Acts Downstream of TGF 1 and Upstream of Smurf1 to Promote Breast Cancer Metastasis

(2015) L. Yu et al.   CANCER RESEARCH

Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion

(2015) Inmaculada Navarro-Lérida et al.   DEVELOPMENTAL CELL

Phosphorylation of Serine 402 Regulates RacGAP Protein Activity of FilGAP Protein

(2015) Yuji Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors

(2015) Stella-Rita C. Ibeawuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

(2015) Anna E. Dart et al.   JOURNAL OF CELL BIOLOGY

Rac1 augments Wnt signaling by stimulating  -catenin-lymphoid enhancer factor-1 complex assembly independent of  -catenin nuclear import

(2015) C. Jamieson et al.   JOURNAL OF CELL SCIENCE

Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity

(2015) E. H. Song et al.   JOURNAL OF CELL SCIENCE

CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling

(2015) Heide Marika Genau et al.   MOLECULAR CELL

An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis

(2015) G Zhu et al.   ONCOGENE

Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression

(2015) E T Goka et al.   ONCOGENE

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation

(2015) Helen J. Whalley et al.   Nature Communications

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

(2015) Sabu Abraham et al.   Nature Communications

A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration

(2015) Xuan Cao et al.   Nature Communications

Coupled local translation and degradation regulate growth cone collapse

(2015) Alessia Deglincerti et al.   Nature Communications

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

(2015) Lynsey Vaughan et al.   Cell Reports

Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway

(2015) Kenji Takemoto et al.   PLoS One

Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint

(2015) Norimasa Tamehiro et al.   PLoS One

Dynamic Control of Excitatory Synapse Development by a Rac1 GEF/GAP Regulatory Complex

(2014) Kyongmi Um et al.   DEVELOPMENTAL CELL

Insights into the biological functions of Dock family guanine nucleotide exchange factors

(2014) M. Laurin et al.   GENES & DEVELOPMENT

Degradation of Tiam1 by Casein Kinase 1 and the SCFβTrCPUbiquitin Ligase Controls the Duration of mTOR-S6K Signaling

(2014) Roberto Magliozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Myosin II-interacting Guanine Nucleotide Exchange Factor (MyoGEF) at Threonine 544 by Aurora B Kinase Promotes the Binding of Polo-like Kinase 1 to MyoGEF

(2014) Di Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone Protein SmgGDS Interacts with Small GTPases Entering the Prenylation Pathway by Recognizing the Last Amino Acid in the CAAXMotif

(2014) Nathan J. Schuld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Activates the Rho GTPase-activating Protein (GAP) Deleted in Liver Cancer 1 via Focal Adhesion Kinase and Protein Phosphatase 2A

(2014) Archna Ravi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte Growth Factor-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier

(2014) Yufeng Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Phosphorylation of Dbl Regulates GTPase Signaling

(2014) Meghana Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK5 is a major regulator of the tumor suppressor DLC1

(2014) Brajendra K. Tripathi et al.   JOURNAL OF CELL BIOLOGY

An Elmo–Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion

(2014) Christopher P. Toret et al.   JOURNAL OF CELL BIOLOGY

The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer

(2014) Junfeng Xu et al.   MOLECULAR & CELLULAR PROTEOMICS

14-3-3  Promotes Breast Cancer Invasion and Metastasis by Inhibiting RhoGDI 

(2014) Y. Xiao et al.   MOLECULAR AND CELLULAR BIOLOGY

F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation

(2014) Su Dong et al.   Molecular Cancer

An extracellular-matrix-specific GEF–GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration

(2014) Matthew L. Kutys et al.   NATURE CELL BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance

(2014) Meilin Wang et al.   Nature Communications

E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics

(2014) Shishan Deng et al.   Cell Adhesion & Migration

I’m coming to GEF you: Regulation of RhoGEFs during cell migration

(2014) Silvia M Goicoechea et al.   Cell Adhesion & Migration

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

A new mechanism of RhoA ubiquitination and degradation: Roles of SCF FBXL19 E3 ligase and Erk2

(2013) Jianxin Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

(2013) Philippe Riou et al.   CELL

Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1

(2013) Gina L. Razidlo et al.   DEVELOPMENTAL CELL

SCF E3 ligase F-box protein complex SCFFBXL19 regulates cell migration by mediating Rac1 ubiquitination and degradation

(2013) Jing Zhao et al.   FASEB JOURNAL

Phosphorylation-mediated 14-3-3 Protein Binding Regulates the Function of the Rho-specific Guanine Nucleotide Exchange Factor (RhoGEF) Syx

(2013) Siu P. Ngok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rho Family Member RhoE Interacts with Skp2 and Is Degraded at the Proteasome during Cell Cycle Progression

(2013) Marta Lonjedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TROY Interacts with Rho Guanine Nucleotide Dissociation Inhibitor α (RhoGDIα) to Mediate Nogo-induced Inhibition of Neurite Outgrowth

(2013) Yan Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of p190RhoGAP with C-terminal Domain of p120-catenin Modulates Endothelial Cytoskeleton and Permeability

(2013) Noureddine Zebda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo

(2013) Ah-Lai Law et al.   JOURNAL OF CELL BIOLOGY

Identification of a Novel Prenyl and Palmitoyl Modification at the CaaX Motif of Cdc42 That Regulates RhoGDI Binding

(2013) A. Nishimura et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of Rac1 T108 by Extracellular Signal-Regulated Kinase in Response to Epidermal Growth Factor: a Novel Mechanism To Regulate Rac1 Function

(2013) Junfeng Tong et al.   MOLECULAR AND CELLULAR BIOLOGY

SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells

(2013) Zipeng Cao et al.   Molecular Oncology

CYLD Regulates RhoA Activity by Modulating LARG Ubiquitination

(2013) Yunfan Yang et al.   PLoS One

APCCDH1 Targets MgcRacGAP for Destruction in the Late M Phase

(2013) Koutarou Nishimura et al.   PLoS One

Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 Signaling

(2013) Maria Eugenia Sabbatini et al.   PLoS One

FERM Domain Containing Protein 7 Interacts with the Rho GDP Dissociation Inhibitor and Specifically Activates Rac1 Signaling

(2013) Jiali Pu et al.   PLoS One

CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth

(2013) T. Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis

(2013) X. Ding et al.   Science Signaling

PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis

(2013) Frankie Chi Fat Ko et al.   Nature Communications

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3

(2012) Carolina L. Bigarella et al.   FEBS LETTERS

RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility

(2012) Jianxiu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of RhoA Signaling by the cAMP-dependent Phosphorylation of RhoGDIα

(2012) Atsuro Oishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation

(2012) Timothy Y. Huang et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKB  Phosphorylation of RhoC GTPase

(2012) H. L. Lehman et al.   MOLECULAR CANCER RESEARCH

PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity

(2012) E M Griner et al.   ONCOGENE

The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation

(2012) S Castillo-Lluva et al.   ONCOGENE

p250GAP Is a Novel Player in the Cdh1-APC/Smurf1 Pathway of Axon Growth Regulation

(2012) Madhuvanthi Kannan et al.   PLoS One

Rho GTPase regulation by miRNAs and covalent modifications

(2012) Ming Liu et al.   TRENDS IN CELL BIOLOGY

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Control of Local Rho GTPase Crosstalk by Abr

(2011) Emily M. Vaughan et al.   CURRENT BIOLOGY

The E3 Ubiquitin-Ligase HACE1 Catalyzes the Ubiquitylation of Active Rac1

(2011) Stéphanie Torrino et al.   DEVELOPMENTAL CELL

A palmitoylation switch mechanism regulates Rac1 function and membrane organization

(2011) Inmaculada Navarro-Lérida et al.   EMBO JOURNAL

IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation

(2011) Tripat Kaur Oberoi et al.   EMBO JOURNAL

Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity

(2011) Maoyuan Tian et al.   FEBS LETTERS

X-linked Inhibitor of Apoptosis Protein (XIAP) Mediates Cancer Cell Motility via Rho GDP Dissociation Inhibitor (RhoGDI)-dependent Regulation of the Cytoskeleton

(2011) Jinyi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SmgGDS Is a Guanine Nucleotide Exchange Factor That Specifically Activates RhoA and RhoC

(2011) Brant Hamel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarity-regulating Kinase Partitioning-defective 1b (PAR1b) Phosphorylates Guanine Nucleotide Exchange Factor H1 (GEF-H1) to Regulate RhoA-dependent Actin Cytoskeletal Reorganization

(2011) Yukie Yamahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDZ-RhoGEF ubiquitination by Cullin3–KLHL20 controls neurotrophin-induced neurite outgrowth

(2011) Mei-Yao Lin et al.   JOURNAL OF CELL BIOLOGY

SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions

(2011) V. Endris et al.   JOURNAL OF CELL SCIENCE

Tiam1 is recruited to β1-integrin complexes by 14-3-3ζ where it mediates integrin-induced Rac1 activation and motility

(2011) Timothy E. O'Toole et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

(2011) Eugene Tkachenko et al.   NATURE CELL BIOLOGY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of E3 Ligase Smurf1 Switches Its Substrate Preference in Support of Axon Development

(2011) Pei-lin Cheng et al.   NEURON

APCcdh1 Mediates Degradation of the Oncogenic Rho-GEF Ect2 after Mitosis

(2011) Caroline Liot et al.   PLoS One

Tyrosine Phosphorylation of Rac1: A Role in Regulation of Cell Spreading

(2011) Fumin Chang et al.   PLoS One

Rnd proteins: Multifunctional regulators of the cytoskeleton and cell cycle progression

(2010) Philippe Riou et al.   BIOESSAYS

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor a with the small GTPase Rac

(2010) Fei Fei et al.   BMC BIOCHEMISTRY

EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation

(2010) Seth S. Margolis et al.   CELL

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation

(2010) Rolf-Peter Scholz et al.   EXPERIMENTAL CELL RESEARCH

Serine 34 Phosphorylation of Rho Guanine Dissociation Inhibitor (RhoGDIα) Links Signaling from Conventional Protein Kinase C to RhoGTPase in Cell Adhesion

(2010) Athanassios Dovas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulation of EGFR-Vav2 Signaling Axis by Cbl Ubiquitin Ligase Controls EGF Receptor-mediated Epithelial Cell Adherens Junction Dynamics and Cell Migration

(2010) Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Splice Variants of SmgGDS Control Small GTPase Prenylation and Membrane Localization

(2010) Tracy J. Berg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic Activity of Ect2 Is Regulated through Protein Kinase Cι-mediated Phosphorylation

(2010) Verline Justilien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anaphase-Promoting Complex/Cyclosome Activator Cdh1 Modulates Rho GTPase by Targeting p190 RhoGAP for Degradation

(2010) H. Naoe et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular Signal-Regulated Kinase Promotes Rho-Dependent Focal Adhesion Formation by Suppressing p190A RhoGAP

(2010) A. K. Pullikuth et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of the Rho Family Small GTPase Wrch-1/RhoU by C-Terminal Tyrosine Phosphorylation Requires Src

(2010) J. K. Alan et al.   MOLECULAR AND CELLULAR BIOLOGY

RhoA Phosphorylation Induces Rac1 Release from Guanine Dissociation Inhibitor   and Stimulation of Vascular Smooth Muscle Cell Migration

(2010) M. Rolli-Derkinderen et al.   MOLECULAR AND CELLULAR BIOLOGY

SUMOylation of the GTPase Rac1 is required for optimal cell migration

(2010) Sonia Castillo-Lluva et al.   NATURE CELL BIOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Regulation of Rnd3 localization and function by protein kinase Cα-mediated phosphorylation

(2009) James P. Madigan et al.   BIOCHEMICAL JOURNAL

New Insights into How the Rho Guanine Nucleotide Dissociation Inhibitor Regulates the Interaction of Cdc42 with Membranes

(2009) Jared L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GEF-H1 Mediates Tumor Necrosis Factor-α-induced Rho Activation and Myosin Phosphorylation

(2009) Eli Kakiashvili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of the RhoA Exchange Factor Net1 with Discs Large Homolog 1 Protects It from Proteasome-mediated Degradation and Potentiates Net1 Activity

(2009) Heather S. Carr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1

(2009) Simon A. Woodcock et al.   MOLECULAR CELL

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function

(2009) Lo-Kong Chan et al.   PLoS One

The C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway

(2009) Dolores Pérez-Sala et al.   PLoS One

Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function

(2009) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rho GTPases of the RhoBTB subfamily and tumorigenesis

(2008) Jessica BERTHOLD et al.   ACTA PHARMACOLOGICA SINICA

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA

(2008) Shuh-hei Fujishiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ste20-Related Kinase SLK Phosphorylates Ser188 of RhoA to Induce Vasodilation in Response to Angiotensin II Type 2 Receptor Activation

(2008) Christophe Guilluy et al.   CIRCULATION RESEARCH

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes — Evidence for an autoregulatory mechanism

(2008) Jessica Berthold et al.   EXPERIMENTAL CELL RESEARCH

Phosphorylation of RhoB by CK1 impedes actin stress fiber organization and epidermal growth factor receptor stabilization

(2008) Vanessa Tillement et al.   EXPERIMENTAL CELL RESEARCH

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

p190A RhoGAP Is a Glycogen Synthase Kinase-3-β Substrate Required for Polarized Cell Migration

(2008) Wei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK5-dependent Phosphorylation of the Rho Family GTPase TC10α Regulates Insulin-stimulated GLUT4 Translocation

(2008) Shuichi Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP

(2008) Kazutaka Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY