The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer
出版年份 2014 全文链接
标题
The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer
作者
关键词
-
出版物
MOLECULAR & CELLULAR PROTEOMICS
Volume 14, Issue 3, Pages 499-509
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2014-12-25
DOI
10.1074/mcp.m114.045211
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression
- (2015) Lijun Jia et al. NEOPLASIA
- Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
- (2014) Hua Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer
- (2014) Lihui Li et al. JNCI-Journal of the National Cancer Institute
- Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases
- (2013) Weihua Zhou et al. CELL RESEARCH
- Negative Regulation of NEDD8 Conjugation Pathway by Novel Molecules and Agents for Anticancer Therapy
- (2013) Tomoaki Tanaka et al. CURRENT PHARMACEUTICAL DESIGN
- A Fast Workflow for Identification and Quantification of Proteomes
- (2013) Chen Ding et al. MOLECULAR & CELLULAR PROTEOMICS
- Expression Loss and Revivification of RhoB Gene in Ovary Carcinoma Carcinogenesis and Development
- (2013) Yingwei Liu et al. PLoS One
- Intratumoral IL-17+ Cells and Neutrophils show Strong Prognostic Significance in Intrahepatic Cholangiocarcinoma
- (2012) Fang-Ming Gu et al. ANNALS OF SURGICAL ONCOLOGY
- Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells
- (2012) Zhongguang Luo et al. Autophagy
- RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells during Breast Tumorigenesis
- (2012) S. Kazerounian et al. CANCER RESEARCH
- The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth
- (2012) Z. Luo et al. CANCER RESEARCH
- Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells
- (2012) D Yang et al. CELL DEATH AND DIFFERENTIATION
- MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy
- (2012) Steffan T Nawrocki et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- A Strategy for Large-Scale Phosphoproteomics and SRM-Based Validation of Human Breast Cancer Tissue Samples
- (2012) Ryohei Narumi et al. JOURNAL OF PROTEOME RESEARCH
- Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents
- (2012) Y. Kee et al. MOLECULAR CANCER RESEARCH
- Inhibition of NEDD8-conjugation pathway by novel molecules: Potential approaches to anticancer therapy
- (2012) Tomoaki Tanaka et al. Molecular Oncology
- WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells
- (2012) C Mackintosh et al. ONCOGENE
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer
- (2011) Meng Wang et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
- (2011) Nieves Embade et al. HEPATOLOGY
- Stereoselective Synthesis of MLN4924, an Inhibitor of NEDD8-Activating Enzyme
- (2011) Hyuk Woo Lee et al. JOURNAL OF ORGANIC CHEMISTRY
- DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy
- (2011) Yongchao Zhao et al. MOLECULAR CELL
- MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma
- (2010) M. A. Milhollen et al. BLOOD
- A distinct role of RhoB in gastric cancer suppression
- (2010) Jitao Zhou et al. INTERNATIONAL JOURNAL OF CANCER
- Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC–MS/MS
- (2010) Richard D Unwin et al. Nature Protocols
- Reactivation of Suppressed RhoB is a Critical Step for the Inhibition of Anaplastic Thyroid Cancer Growth
- (2009) Laura A. Marlow et al. CANCER RESEARCH
- ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence
- (2009) L. Jia et al. CANCER RESEARCH
- Loss of RhoB Expression Promotes Migration and Invasion of Human Bronchial Cells Via Activation of AKT1
- (2009) E. Bousquet et al. CANCER RESEARCH
- A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
- (2009) Ji Luo et al. CELL
- E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification
- (2009) Danny T. Huang et al. MOLECULAR CELL
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
- (2009) Teresa A. Soucy et al. NATURE
- The C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway
- (2009) Dolores Pérez-Sala et al. PLoS One
- Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1
- (2008) Dimitris P. Xirodimas BIOCHEMICAL SOCIETY TRANSACTIONS
- In vivo restoration of RhoB expression leads to ovarian tumor regression
- (2008) B Couderc et al. CANCER GENE THERAPY
- Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes
- (2008) Imsang Lee et al. CELL
- Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series
- (2008) Gwénaël Rabut et al. EMBO REPORTS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now