Article
Biochemistry & Molecular Biology
Yukihiro Sera, Miki Sadoya, Takashi Ichinose, Shinji Matsuya, Tsuneo Imanaka, Masafumi Yamaguchi
Summary: Shwachman-Diamond syndrome is a genetic disorder caused by mutation in the SBDS gene, and this study identifies Ring finger protein 2 as a candidate for SBDS interactor and shows that it promotes the degradation of SBDS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Pu Li, Tingting Chen, Peng Kuang, Fujun Liu, Zhongmin Li, Fangfang Liu, Yu Wang, Wenfeng Zhang, Xiuyu Cai
Summary: This study reveals that the Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in ccRCC, and the double inhibition of SKP2 and Aur-A shows significant synergistic effect, indicating a potential new therapeutic strategy for ccRCC.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Jia Ma, Wenyang Zhou, Yifeng Yuan, Baosheng Wang, Xiangpeng Meng
Summary: PSMD12 is highly expressed in pancreatic cancer and associated with poor prognosis. It promotes cell proliferation and inhibits apoptosis by interacting with CDKN3 and regulating its expression. These findings highlight the crucial role of PSMD12 in pancreatic cancer development.
CANCER GENE THERAPY
(2023)
Article
Immunology
Xubin Dong, Qingwen Yang, Junwei Gu, Shihui Lv, Dandan Song, Danxiang Chen, Jingjing Song, Xiaohua Zhang, Duping Huang
Summary: The study revealed that LAGE3 is significantly up-regulated in various solid tumors, including PTC, and is highly associated with advanced malignancy, cancer-related pathways, biochemical metabolism, and immune-related terms. Additionally, LAGE3 plays an important role in the tumor microenvironment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Edward J. Strini, Ligia T. Bertolino, Juca A. B. San Martin, Hebreia A. O. Souza, Francine Pessotti, Vitor F. Pinoti, Pedro B. Ferreira, Henrique C. De Paoli, Greice Lubini, Luiz-Eduardo Del-Bem, Andrea C. Quiapim, Mateus Mondin, Ana Paula U. Araujo, Nubia B. Eloy, Matteo Barberis, Maria Helena S. Goldman
Summary: The gene SCI1 plays an important role in regulating cell proliferation during pistil development. In this study, the protein 14-3-3D was identified as an interaction partner of SCI1. The degradation of SCI1 is dependent on phosphorylation and the action of the 26S proteasome, and its stability/degradation is cell-cycle regulated.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Shi Li, Yu Liu, Yifeng Bai, Min Chen, Donghui Cheng, Mengwan Wu, Jianling Xia
Summary: RHOF, a member of the Rho guanosine triphosphatase family, is significantly related to HCC metastasis and frequently up-regulated in HCC tumor samples. It enhances HCC cell migration and invasion by modulating the Warburg effect and directly interacting with AMPK to affect RAB3D mRNA stability. RHOF shows potential as a therapeutic target and prognostic biomarker for HCC.
Article
Biotechnology & Applied Microbiology
Hailin Ke, Songling Wu, Yueyi Zhang, Guowei Zhang
Summary: miR-139-3p suppresses gastric cancer by inhibiting the proliferative, migratory, and invasive abilities of GC cells through targeting KIF18B.
Review
Biochemistry & Molecular Biology
Mateusz Gielata, Kamila Karpinska, Tomasz Pieczonka, Agnieszka Kobielak
Summary: This review highlights the recent discoveries on the involvement of alpha-catulin in diverse biological processes, with a focus on its role in cancer progression. The molecular basis of its actions and control of various signals during morphogenesis and tissue homeostasis, however, remains elusive.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Li-Hung Chen, Stjepan K. Kracun, Karen S. Nissen, Jozef Mravec, Bodil Jorgensen, John Labavitch, Ioannis Stergiopoulos
Summary: Gene duplication in the Avr4 effector family led to the emergence of a new paralog, Avr4-2, which interacts with pectin in plant cell walls, disrupting Ca2+-mediated cross-linking and weakening the plant cell wall structure. This enhances the activity of pathogen secreted endo-polygalacturonases.
Article
Biochemistry & Molecular Biology
Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Hockendorf, Michelle Dietzen, Marta Dechant, Martina Anton, Anne Jacob, Katja Steiger, Wilko Weichert, Luka Brcic, Nicholas McGranahan, Caterina Branca, Thomas Kaufmann, Michael A. Dengler, Philipp J. Jost
Summary: This study demonstrates the tumor-promoting function of the BOK gene in Kras-driven lung cancer through in vivo experiments in a mouse model.
Article
Biochemistry & Molecular Biology
Qin Yao, Patricia Outeda, Hangxue Xu, Rebecca Walker, Denis Basquin, Feng Qian, Liudmila Cebotaru, Terry Watnick, Valeriu Cebotaru
Summary: Autosomal dominant polycystic kidney disease is a common inherited renal disorder caused by mutations in PKD1 or PKD2 genes. Increased expression of PC2 in PKD1 mutant tissues is due in part to an increase in Pkd2 mRNA, as well as more effective protein folding. The unfolded protein response is activated in Pkd1 knockout kidneys and mutant cells, with GRP94 serving as a chaperone for PC2, and a novel HDAC6-GRP94-related axis likely regulating PC2 levels.
Article
Oncology
Xubin Dong, Shihui Lv, Dianna Gu, Xiaohua Zhang, Zhiqiang Ye
Summary: The study revealed that LAGE3 plays a role in promoting the progression of breast cancer, and it may serve as a potential diagnostic and prognostic biomarker, as well as a treatment target for breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xue Zhang, Saiyan Bian, Yao Ni, Linlin Zhou, Chenyu Yang, Chenfeng Zhang, Xieyin Sun, Nuo Xu, Shiyu Xu, Yilang Wang, Shudong Gu, Wenjie Zheng
Summary: With limited therapeutic options for hepatocellular carcinoma (HCC), it is important to investigate underlying mechanisms and tumor drivers. MCM6, a member of the MCM protein family, is elevated in HCC and associated with poor prognosis. Knocking down MCM6 inhibits proliferation and migration of HCC cells, while overexpression of MCM6 has adverse effects. Mechanistically, MCM6 decreases P53 activity by inducing its degradation and enhances P53 ubiquitination by recruiting UBE3A. Overexpression of UBE3A rescues P53 activation and suppresses malignant behaviors mediated by MCM6 inhibition. In conclusion, MCM6 facilitates aggressive phenotypes in HCC cells through UBE3A/P53 signaling, providing potential biomarkers and targets for HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, General & Internal
Qiao-Yun Zhou, Shu-Yu Gui, Peng Zhang, Mei Wang
Summary: MiR-345-5p acts as a tumor suppressor in lung adenocarcinoma cells by downregulating RhoA to inactivate the Rho/ROCK pathway.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biology
Nehal Gupta, Hanbing Song, Wei Wu, Rovingaile K. Ponce, Yone K. Lin, Ji Won Kim, Eric J. Small, Felix Y. Feng, Franklin W. Huang, Ross A. Okimoto
Summary: This study reveals that the concurrent loss of CIC and ERF can drive prostate oncogenesis by mutually repressing ETS transcription factor ETV1. Targeting ETV1 can limit the growth of CIC and ERF-deficient prostate cancer.
Article
Medicine, Research & Experimental
Maria L. Mansego, Griselda De Marco, Carmen Ivorra, Raul Lopez-Izquierdo, Sonsoles Morcillo, Gemma Rojo-Martinez, Veronica Gonzalez-Albert, Fernando Martinez, Federico Soriguer, Juan C. Martin-Escudero, Josep Redon, F. Javier Chaves
JOURNAL OF TRANSLATIONAL MEDICINE
(2015)
Article
Oncology
Marta Hernandez-Sanchez, Enric Poch, Rosa M. Guasch, Joaquin Ortega, Inmaculada Lopez-Almela, Ignacio Palmero, Ignacio Perez-Roger
Article
Medicine, Research & Experimental
Raquel Cortes, Carmen Ivorra, Sergio Martinez-Hervas, Teresa Pedro, Veronica Gonzalez-Albert, Ana Artero, Victoria Adam, Ana B. Garcia-Garcia, Juan F. Ascaso, Jose T. Real, Felipe J. Chaves
ARCHIVES OF MEDICAL RESEARCH
(2016)
Article
Anatomy & Morphology
Begona Ballester-Lurbe, Susana Gonzalez-Granero, Enric Mocholi, Enric Poch, Maria Garcia-Manzanares, Mara Dierssen, Ignacio Perez-Roger, Jose M. Garcia-Verdugo, Rosa M. Guasch, Jose Terrado
BRAIN STRUCTURE & FUNCTION
(2015)
Article
Cell Biology
Laura Trachsel-Moncho, Soledad Benlloch-Navarro, Angel Fernandez-Carbonell, Dolores Tania Ramirez-Lamelas, Teresa Olivar, Dolores Silvestre, Enric Poch, Maria Miranda
CELL DEATH & DISEASE
(2018)
Article
Medical Laboratory Technology
Sebastian Blesa, Maria D. Olivares, Andy S. Alic, Alicia Serrano, Veronica Lendinez, Veronica Gonzalez-Albert, Laura Olivares, Sergio Martinez-Hervas, Jose M. Juanes, Pablo Marin, Jose T. Real, Blanca Navarro, Ana B. Garcia-Garcia, Felipe J. Chaves, Carmen Ivorra
CLINICAL CHEMISTRY
(2020)
Article
Neurosciences
Navjot Kaur, Wenqi Han, Zhuo Li, M. Pilar Madrigal, Sungbo Shim, Sirisha Pochareddy, Forrest O. Gulden, Mingfeng Li, Xuming Xu, Xiaojun Xing, Yutaka Takeo, Zhen Li, Kangrong Lu, Yuka Imamura Kawasawa, Begona Ballester-Lurbe, Juan Antonio Moreno-Bravo, Alain Chedotal, Jose Terrado, Ignacio Perez-Roger, Anthony J. Koleske, Nenad Sestan
Article
Biochemistry & Molecular Biology
Pau Marfull-Oromi, Catherine Fleitas, Bahira Zammou, Daniel Rocandio, Begona Ballester-Lurbe, Jose Terrado, Ignacio Perez-Roger, Carme Espinet, Joaquim Egea
Summary: Rnd3 plays a crucial role in early brain development, regulating subpallium development and providing new insights into the development of SAs and TCAs.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Anatomy & Morphology
M. P. Madrigal, B. Ballester-Lurbe, O. Gomez, J. A. Moreno-Bravo, E. Puelles, S. Jurado, J. M. Garcia-Verdugo, I. Perez-Roger, Jose Terrado
Summary: Rnd3 is a protein involved in oligodendrocyte maturation, with potential roles in the development of the central nervous system and demyelinating diseases. Its absence leads to hypomyelination, reduced oligodendrocyte numbers, and thinner myelin sheaths in mice, indicating its crucial role in myelination.
BRAIN STRUCTURE & FUNCTION
(2022)
Review
Cell Biology
Olga Gomez, Giuliana Perini-Villanueva, Andrea Yuste, Jose Antonio Rodriguez-Navarro, Enric Poch, Eloy Bejarano
Summary: Autophagy is a crucial process in maintaining brain health by clearing dysfunctional cellular components, but its decline with age can lead to neurodegenerative disorders. Glycative stress, characterized by the accumulation of AGEs, negatively impacts brain health and may interfere with autophagic function. While autophagy can help remove harmful AGEs, excessive glycative stress may hinder its cytoprotective role in neurons and glial cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Cristina Cueto-Urena, Enric Mocholi, Josep Escriva-Fernandez, Susana Gonzalez-Granero, Sabina Sanchez-Hernandez, Amalia Solana-Orts, Begona Ballester-Lurbe, Karim Benabdellah, Rosa M. Guasch, Jose Manuel Garcia-Verdugo, Francisco Martin, Paul J. Coffer, Ignacio Perez-Roger, Enric Poch
Summary: This study reveals that loss of Rnd3 expression affects mitochondrial oxidative metabolism and renders cells dependent on glycolysis for energy, suggesting a possible connection to neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Josep Escriva-Fernandez, Cristina Cueto-Urena, Amalia Solana-Orts, Elisa Lledo, Begona Ballester-Lurbe, Enric Poch
Summary: In this study, a CRISPR interference strategy was employed to repress Rnd3 expression in MM cell lines. Lentiviral particles were used to transduce the cell lines and downregulate Rnd3 expression. Transcriptomic analysis revealed distinct gene expression profiles in the Rnd3 knockdown cells compared to the control cells.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)