PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis

(2014) Michael Dickover et al.   DEVELOPMENTAL BIOLOGY

RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly

(2014) E. Wilson et al.   JOURNAL OF CELL SCIENCE

NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1

(2013) Wei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ubiquitin — omics reveals novel networks and associations with human disease

(2013) Benedikt M Kessler   CURRENT OPINION IN CHEMICAL BIOLOGY

P21-activated kinase 4 – Not just one of the PAK

(2013) Anna E. Dart et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation

(2013) A. Teckchandani et al.   JOURNAL OF CELL SCIENCE

Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV

(2012) M. V. Shepelev et al.   BIOCHEMISTRY-MOSCOW

Group I and II mammalian PAKs have different modes of activation by Cdc42

(2012) Yohendran Baskaran et al.   EMBO REPORTS

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

(2012) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling

(2012) H. Tabusa et al.   MOLECULAR CANCER RESEARCH

ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression

(2012) Bo Rafn et al.   MOLECULAR CELL

Coordination between RAB GTPase and phosphoinositide regulation and functions

(2012) Steve Jean et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity

(2012) A D Whale et al.   ONCOGENE

p21-Activated kinase 4 promotes prostate cancer progression through CREB

(2012) M-H Park et al.   ONCOGENE

Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration

(2012) P J Bhavsar et al.   ONCOGENE

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

(2012) B. H. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K63-Linked Ubiquitination in Kinase Activation and Cancer

(2012) Guocan Wang et al.   Frontiers in Oncology

Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling

(2011) Yan Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells

(2011) Jian Zhang et al.   CANCER LETTERS

Notice of Retraction

(2011)   CARCINOGENESIS

Structure and function of focal adhesions

(2011) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis

(2010) Guillaume Bompard et al.   JOURNAL OF CELL BIOLOGY

The role of ubiquitylation and degradation in RhoGTPase signalling

(2010) Micha Nethe et al.   JOURNAL OF CELL SCIENCE

PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion

(2010) C. M. Wells et al.   JOURNAL OF CELL SCIENCE

Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

(2010) M. Nethe et al.   JOURNAL OF CELL SCIENCE

Cdc42 Regulates Apical Junction Formation in Human Bronchial Epithelial Cells through PAK4 and Par6B

(2010) Sean W. Wallace et al.   MOLECULAR BIOLOGY OF THE CELL

The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis

(2010) Y Liu et al.   ONCOGENE

p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

(2010) M. K. Y. Siu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

(2010) B. W. Murray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways

(2009) Davide Schiavone et al.   BIOCHEMICAL JOURNAL

Chromosomal changes in aggressive breast cancers with basal-like features

(2009) Wayne Yu et al.   CANCER GENETICS AND CYTOGENETICS

Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4motif: evidence that nuclear paxillin promotes cell proliferation

(2008) Jing-Ming Dong et al.   BIOCHEMICAL JOURNAL

A PAK4–LIMK1 pathway drives prostate cancer cell migration downstream of HGF

(2008) Tasneem Ahmed et al.   CELLULAR SIGNALLING

The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice

(2008) Y. Liu et al.   MOLECULAR CANCER RESEARCH

UnPAKing the class differences among p21-activated kinases

(2008) Jeyanthy Eswaran et al.   TRENDS IN BIOCHEMICAL SCIENCES