ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance

NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription

(2013) Kyoung-Jae Won et al.   APOPTOSIS

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

(2013) Mallikarjun Patil et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 4 (TRAF4) by Smad Ubiquitination Regulatory Factor 1 (Smurf1) Regulates Motility of Breast Epithelial and Cancer Cells

(2013) Xiangchun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis

(2013) H. Suzuki et al.   JOURNAL OF CELL SCIENCE

Smurf1-Mediated Lys29-Linked Nonproteolytic Polyubiquitination of Axin Negatively Regulates Wnt/ -Catenin Signaling

(2013) C. Fei et al.   MOLECULAR AND CELLULAR BIOLOGY

SMURF1 Plays a role in EGF-induced breast cancer cell migration and invasion

(2013) Arang Kwon et al.   MOLECULES AND CELLS

CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation

(2013) J Nie et al.   ONCOGENE

PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis

(2013) H Lin et al.   ONCOGENE

Expression Loss and Revivification of RhoB Gene in Ovary Carcinoma Carcinogenesis and Development

(2013) Yingwei Liu et al.   PLoS One

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks

(2012) Yu Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter

(2011) Jiwon Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity

(2011) Maoyuan Tian et al.   FEBS LETTERS

miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells

(2011) Ming Liu et al.   FEBS LETTERS

Genome profiling of pancreatic adenocarcinoma

(2011) David J. Birnbaum et al.   GENES CHROMOSOMES & CANCER

Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection

(2011) Kefeng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMURF1 Amplification Promotes Invasiveness in Pancreatic Cancer

(2011) Kevin A. Kwei et al.   PLoS One

Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618

(2010) Bo-Kyung Kim et al.   CARCINOGENESIS

A distinct role of RhoB in gastric cancer suppression

(2010) Jitao Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

NSC126188, a piperazine alkyl derivative, induces apoptosis via upregulation of RhoB in HeLa cells

(2010) Bo-Kyung Kim et al.   INVESTIGATIONAL NEW DRUGS

Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2

(2010) Jing Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases

(2009) Masahiro Narimatsu et al.   CELL

RhoB induces apoptosisviadirect interaction with TNFAIP1 in HeLa cells

(2009) Dong-Myung Kim et al.   INTERNATIONAL JOURNAL OF CANCER

The C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway

(2009) Dolores Pérez-Sala et al.   PLoS One

In vivo restoration of RhoB expression leads to ovarian tumor regression

(2008) B Couderc et al.   CANCER GENE THERAPY

Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization

(2008) Ayako Suzuki et al.   CANCER SCIENCE

Smurf2 Induces Ubiquitin-dependent Degradation of Smurf1 to Prevent Migration of Breast Cancer Cells

(2008) Erina Fukunaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY