Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors

Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

(2014) James A. McCormick et al.   JOURNAL OF CLINICAL INVESTIGATION

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation

(2013) Guojin Wu et al.   FEBS LETTERS

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

(2013) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

(2013) Mai Wakabayashi et al.   Cell Reports

Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase

(2012) Christopher J. Pelham et al.   Cell Metabolism

Selective Proteasomal Degradation of the B′β Subunit of Protein Phosphatase 2A by the E3 Ubiquitin Ligase Adaptor Kelch-like 15

(2012) Elizabeth A. Oberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

Mechanism of Cullin3 E3 Ubiquitin Ligase Dimerization

(2012) Yin Yin Choo et al.   PLoS One

The Cullin-RING E3 Ubiquitin Ligase CRL4−DCAF1 Complex Dimerizes via a Short Helical Region in DCAF1

(2011) Jinwoo Ahn et al.   BIOCHEMISTRY

A Dual E3 Mechanism for Rub1 Ligation to Cdc53

(2010) Daniel C. Scott et al.   MOLECULAR CELL

The role of Rho protein signaling in hypertension

(2010) Gervaise Loirand et al.   Nature Reviews Cardiology

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

Detection of Protein Ubiquitination

(2009) Yeun Su Choo et al.   Jove-Journal of Visualized Experiments

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes — Evidence for an autoregulatory mechanism

(2008) Jessica Berthold et al.   EXPERIMENTAL CELL RESEARCH