Article
Biochemistry & Molecular Biology
Thomas McFall, Jolene K. Diedrich, Meron Mengistu, Stacy L. Littlechild, Kendra V. Paskvan, Laura Sisk-Hackworth, James J. Moresco, Andrey S. Shaw, Edward C. Stites
Article
Biochemistry & Molecular Biology
Deepika Jaiswal, Rashi Turniansky, James J. Moresco, Sabeen Ikram, Ganesh Ramaprasad, Assefa Akinwole, Julie Wolf, John R. Yates, Erin M. Green
MOLECULAR AND CELLULAR BIOLOGY
(2020)
Article
Infectious Diseases
Tae Kwon Kim, Lucas Tirloni, Antonio F. M. Pinto, Jolene K. Diedrich, James J. Moresco, John R. Yates, Itabajara da Silva Vaz, Albert Mulenga
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Shen Yang, Mattias N. D. Svensson, Nathaniel H. O. Harder, Wan-Chen Hsieh, Eugenio Santelli, William B. Kiosses, James J. Moresco, John R. Yates, Charles C. King, Lin Liu, Stephanie M. Stanford, Nunzio Bottini
Article
Cell Biology
Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, Jin Billy Li
Article
Biology
Gregory G. Fuller, Ting Han, Mallory A. Freeberg, James J. Moresco, Amirhossein Ghanbari Niaki, Nathan P. Roach, John R. Yates, Sua Myong, John K. Kim
Article
Biochemistry & Molecular Biology
Bandar Alghanem, Rizwan Ali, Atef Nehdi, Hajar Al Zahrani, Abdulelah Altolayyan, Hayat Shaibah, Omar Baz, Alshaimaa Alhallaj, James J. Moresco, Jolene K. Diedrich, John R. Yates, Mohamed Boudjelal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Meirong Chen, Bernhard Kuhle, Jolene Diedrich, Ze Liu, James J. Moresco, John R. Yates, Tao Pan, Xiang-Lei Yang
NUCLEIC ACIDS RESEARCH
(2020)
Article
Medicine, Research & Experimental
Helen Chen, A. Kaitlyn Victor, Jonathon Klein, Klementina Fon Tacer, Derek J. C. Tai, Celine de Esch, Alexander Nuttle, Jamshid Temirov, Lisa C. Burnett, Michael Rosenbaum, Yiying Zhang, Li Ding, James J. Moresco, Jolene K. Diedrich, John R. Yates, Heather S. Tillman, Rudolph L. Leibel, Michael E. Talkowski, Daniel D. Billadeau, Lawrence T. Reiter, Patrick Ryan Potts
Article
Biochemistry & Molecular Biology
Daniel A. Chaves, Hui Dai, Lichao Li, James J. Moresco, Myung Eun Oh, Darryl Conte, John R. Yates, Craig C. Mello, Weifeng Gu
Summary: PIR-1 phosphatase can remove phosphate groups from ppp-RNAs, promoting the maturation of small RNAs and playing critical roles in RNA regulation in both cells and viruses.
Article
Cell Biology
Kristina Seiler, Magali Humbert, Petra Minder, Iris Mashimo, Anna M. Schlafli, Deborah Krauer, Elena A. Federzoni, Bich Vu, James J. Moresco, John R. Yates, Martin C. Sadowski, Ramin Radpour, Thomas Kaufmann, Jean-Emmanuel Sarry, Joern Dengjel, Mario P. Tschan, Bruce E. Torbett
Summary: This study found that HK3 is dispensable for glycolytic activity in AML cells while promoting cell survival, possibly through direct interaction with the BH3-only protein BIM during ATRA-induced neutrophil differentiation.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena Cortes-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Mo Li, Juan Carlos Izpisua Belmonte
Summary: In this study, the authors revealed that WASP deficiency results in aberrant RNA splicing and that WASP regulates the transcription of splicing factor genes and co-transcriptional RNA splicing through a phase-separation process involving splicing factors and nascent RNA.
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortes-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Juan Carlos Izpisua Belmonte, Mo Li
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Sujin Lee, Stephen Abini-Agbomson, Daniela S. Perry, Allen Goodman, Beiduo Rao, Manning Y. Huang, Jolene K. Diedrich, James J. Moresco, John R. R. Yates III, Karim-Jean Armache, Hiten D. Madhani
Summary: The Polycomb-like protein Ccc1 in Cryptococcus neoformans maintains the separation of HP1 and Polycomb heterochromatin domains through phase separation. The ability of Ccc1 to form condensates in vivo, which are enriched for PRC2, is dependent on its phase separation behavior driven by the intrinsically disordered region and the coiled-coil dimerization domain. Mutations that alter phase separation of Ccc1 lead to ectopic H3K27me3 at HP1 domains. These findings provide a biochemical basis for chromatin regulation where mesoscale biophysical properties play a crucial functional role.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tim Sonntag, Jelena Ostojic, Joan M. Vaughan, James J. Moresco, Young-Sil Yoon, John R. Yates, Marc Montminy