标题
Induced pluripotent stem cell technology: a decade of progress
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 16, Issue 2, Pages 115-130
出版商
Springer Nature
发表日期
2016-12-17
DOI
10.1038/nrd.2016.245
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies
- (2016) Evangeline Tzatzalos et al. ADVANCED DRUG DELIVERY REVIEWS
- Genome editing in pluripotent stem cells: research and therapeutic applications
- (2016) Michela Deleidi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Toward more predictive genetic mouse models of Alzheimer's disease
- (2016) Kristen D. Onos et al. BRAIN RESEARCH BULLETIN
- Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
- (2016) Xuyu Qian et al. CELL
- Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro
- (2016) Elena Matsa et al. Cell Stem Cell
- 10 Questions: Clinical Outlook for iPSCs
- (2016) Cell Stem Cell
- Current Public Support for Human-Animal Chimera Research in Japan Is Limited, Despite High Levels of Scientific Approval
- (2016) Yusuke Inoue et al. Cell Stem Cell
- 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size
- (2016) Tomoki Otani et al. Cell Stem Cell
- Induced Pluripotent Stem Cells Meet Genome Editing
- (2016) Dirk Hockemeyer et al. Cell Stem Cell
- CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs
- (2016) Mohammad A. Mandegar et al. Cell Stem Cell
- Engineering Stem Cell Organoids
- (2016) Xiaolei Yin et al. Cell Stem Cell
- CPAP promotes timely cilium disassembly to maintain neural progenitor pool
- (2016) Elke Gabriel et al. EMBO JOURNAL
- Organoid Models of Human Gastrointestinal Development and Disease
- (2016) Priya H. Dedhia et al. GASTROENTEROLOGY
- Innovation in the pharmaceutical industry: New estimates of R&D costs
- (2016) Joseph A. DiMasi et al. JOURNAL OF HEALTH ECONOMICS
- A New Glucocerebrosidase Chaperone Reduces -Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism
- (2016) E. Aflaki et al. JOURNAL OF NEUROSCIENCE
- Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes
- (2016) Mei-Chen Liao et al. JOURNAL OF NEUROSCIENCE
- Translation of Human-Induced Pluripotent Stem Cells
- (2016) Nazish Sayed et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- How iPS cells changed the world
- (2016) Megan Scudellari NATURE
- Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
- (2016) Dominik Paquet et al. NATURE
- Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
- (2016) Frank Soldner et al. NATURE
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Organoids as an in vitro model of human development and disease
- (2016) Aliya Fatehullah et al. NATURE CELL BIOLOGY
- ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks
- (2016) Ritchie Ho et al. NATURE NEUROSCIENCE
- Evolution of strategies to improve preclinical cardiac safety testing
- (2016) Gary Gintant et al. NATURE REVIEWS DRUG DISCOVERY
- Pluripotent stem cells in disease modelling and drug discovery
- (2016) Yishai Avior et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pluripotent stem cells progressing to the clinic
- (2016) Alan Trounson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A decade of transcription factor-mediated reprogramming to pluripotency
- (2016) Kazutoshi Takahashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience
- (2016) Jerome Mertens et al. NATURE REVIEWS NEUROSCIENCE
- Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain
- (2016) Jinju Han et al. NEURON
- Zika virus impairs growth in human neurospheres and brain organoids
- (2016) P. P. Garcez et al. SCIENCE
- Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery
- (2016) S. Aday et al. TRENDS IN BIOTECHNOLOGY
- Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
- (2016) Chikafumi Ozone et al. Nature Communications
- Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
- (2016) Brandon L. Pearson et al. Nature Communications
- The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model
- (2016) Kiyohito Murai et al. Nature Communications
- Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes
- (2016) E Tian et al. Cell Reports
- Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells
- (2016) Aaron Topol et al. Cell Reports
- iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System
- (2016) Andrés Javier Orqueda et al. Stem Cells International
- Comparison of Magnetic Resonance Imaging and Serum Biomarkers for Detection of Human Pluripotent Stem Cell-Derived Teratomas
- (2016) Johannes Riegler et al. Stem Cell Reports
- Potential Strategies to Address the Major Clinical Barriers Facing Stem Cell Regenerative Therapy for Cardiovascular Disease
- (2016) Patricia K. Nguyen et al. JAMA Cardiology
- Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction
- (2016) Chao Li et al. Scientific Reports
- From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing
- (2015) Akitsu Hotta et al. Annual Review of Genetics
- Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks
- (2015) Amir M Hossini et al. BMC GENOMICS
- FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
- (2015) Jessica Mariani et al. CELL
- Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches
- (2015) Kenji Miki et al. Cell Stem Cell
- Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency
- (2015) Lorenz Studer et al. Cell Stem Cell
- Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9
- (2015) Chul-Yong Park et al. Cell Stem Cell
- Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells
- (2015) Tongbiao Zhao et al. Cell Stem Cell
- Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
- (2015) Jerome Mertens et al. Cell Stem Cell
- Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells
- (2015) Jessica E. Young et al. Cell Stem Cell
- From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial
- (2015) John McNeish et al. Cell Stem Cell
- Modeling mouse and human development using organoid cultures
- (2015) M. Huch et al. DEVELOPMENT
- Transdifferentiation via transcription factors or microRNAs: Current status and perspective
- (2015) Huan Wang et al. DIFFERENTIATION
- Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients
- (2015) R. Fernandez-Santiago et al. EMBO Molecular Medicine
- Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report: Figure 1
- (2015) Philippe Menasché et al. EUROPEAN HEART JOURNAL
- Rodent models for Alzheimer’s disease drug discovery
- (2015) Daniela Puzzo et al. Expert Opinion on Drug Discovery
- Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges
- (2015) Yu Seah et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hurdles to clinical translation of human induced pluripotent stem cells
- (2015) Evgenios Neofytou et al. JOURNAL OF CLINICAL INVESTIGATION
- Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
- (2015) Jerome Mertens et al. NATURE
- Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
- (2015) Minoru Takasato et al. NATURE
- Directed differentiation of cholangiocytes from human pluripotent stem cells
- (2015) Mina Ogawa et al. NATURE BIOTECHNOLOGY
- Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
- (2015) Fotios Sampaziotis et al. NATURE BIOTECHNOLOGY
- Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
- (2015) Anca M Paşca et al. NATURE METHODS
- Current status of pluripotent stem cells: moving the first therapies to the clinic
- (2015) Erin A. Kimbrel et al. NATURE REVIEWS DRUG DISCOVERY
- Stem-cell discovery platforms yield first clinical candidates
- (2015) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
- (2015) Antonia A. Dominguez et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Human secreted tau increases amyloid-beta production
- (2015) Jessica Bright et al. NEUROBIOLOGY OF AGING
- The $2.6 Billion Pill — Methodologic and Policy Considerations
- (2015) Jerry Avorn NEW ENGLAND JOURNAL OF MEDICINE
- Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
- (2015) Cedric Bardy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Swimming muscles power suction feeding in largemouth bass
- (2015) Ariel L. Camp et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human pluripotent stem cell-derived neural constructs for predicting neural toxicity
- (2015) Michael P. Schwartz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- Developing predictive assays: The phenotypic screening “rule of 3”
- (2015) Fabien Vincent et al. Science Translational Medicine
- In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination
- (2015) Michelle J. Smith et al. STEM CELLS
- Do Human Leukocyte Antigen-Typed Cellular Therapeutics Based on Induced Pluripotent Stem Cells Make Commercial Sense?
- (2015) Christopher A. Bravery STEM CELLS AND DEVELOPMENT
- Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform
- (2015) Yusheng Qu et al. TOXICOLOGICAL SCIENCES
- Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
- (2015) Anna-Claire Devlin et al. Nature Communications
- Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue
- (2015) Hideya Sakaguchi et al. Nature Communications
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells
- (2015) Emi Shoji et al. Scientific Reports
- Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs
- (2015) Amy L. Firth et al. Cell Reports
- Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting
- (2015) Chia-Wei Chang et al. Cell Reports
- APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons
- (2015) Steven Moore et al. Cell Reports
- Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells
- (2015) Keiko Muguruma et al. Cell Reports
- High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells
- (2015) Daman Kumari et al. Stem Cells Translational Medicine
- In vitro generation of human pluripotent stem cell derived lung organoids
- (2015) Briana R Dye et al. eLife
- Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines
- (2015) Atossa Shaltouki et al. Stem Cell Reports
- Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
- (2014) S. Bae et al. BIOINFORMATICS
- Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity
- (2014) Ki-Jun Yoon et al. Cell Stem Cell
- Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing
- (2014) Adrian Veres et al. Cell Stem Cell
- Whole-Genome Sequencing Analysis Reveals High Specificity of CRISPR/Cas9 and TALEN-Based Genome Editing in Human iPSCs
- (2014) Cory Smith et al. Cell Stem Cell
- Induced pluripotent stem cell-derived myeloid phagocytes: disease modeling and therapeutic applications
- (2014) Helen S. Goodridge DRUG DISCOVERY TODAY
- iPS cells: a game changer for future medicine
- (2014) H. Inoue et al. EMBO JOURNAL
- The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
- (2014) Christina R. Muratore et al. HUMAN MOLECULAR GENETICS
- Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease
- (2014) Jong Kil Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death
- (2014) Lishu Duan et al. Molecular Neurodegeneration
- Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
- (2014) K Brennand et al. MOLECULAR PSYCHIATRY
- Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
- (2014) Kyle W. McCracken et al. NATURE
- Statin treatment rescues FGFR3 skeletal dysplasia phenotypes
- (2014) Akihiro Yamashita et al. NATURE
- Synaptic dysregulation in a human iPS cell model of mental disorders
- (2014) Zhexing Wen et al. NATURE
- An in vivo model of human small intestine using pluripotent stem cells
- (2014) Carey L Watson et al. NATURE MEDICINE
- Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons
- (2014) Elizabeth M. Hartfield et al. PLoS One
- Organogenesis in a dish: Modeling development and disease using organoid technologies
- (2014) M. A. Lancaster et al. SCIENCE
- SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
- (2014) N. A. Naryshkin et al. SCIENCE
- Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response
- (2014) Ke Huang et al. Science China-Life Sciences
- Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-Derived Human Neurons
- (2014) Yong Ren et al. STEM CELLS
- Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties
- (2014) Vasiliki Mahairaki et al. STEM CELLS AND DEVELOPMENT
- iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
- (2014) David C. Schöndorf et al. Nature Communications
- Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance
- (2014) Patricia .E de Almeida et al. Nature Communications
- In vitro organogenesis from pluripotent stem cells
- (2014) Yan Li et al. Organogenesis
- Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons
- (2014) Brian J. Wainger et al. Cell Reports
- iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
- (2014) Chris M. Woodard et al. Cell Reports
- Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers
- (2014) Qing Liu et al. JAMA Neurology
- Single-Cell Gene Expression Profiles Define Self-Renewing, Pluripotent, and Lineage Primed States of Human Pluripotent Stem Cells
- (2014) Shelley R. Hough et al. Stem Cell Reports
- Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation
- (2014) Daisuke Doi et al. Stem Cell Reports
- Identification of rare variants in Alzheimer’s disease
- (2014) Jenny Lord et al. Frontiers in Genetics
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
- (2013) Baohui Chen et al. CELL
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
- (2013) Scott D. Ryan et al. CELL
- Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
- (2013) Justine D. Miller et al. Cell Stem Cell
- Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression
- (2013) Peter Reinhardt et al. Cell Stem Cell
- Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen
- (2013) Uri Ben-David et al. Cell Stem Cell
- Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture
- (2013) Yoshiki Sasai Cell Stem Cell
- Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
- (2013) Takayuki Kondo et al. Cell Stem Cell
- A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells
- (2013) Matthew F. Burkhardt et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Cytosystems dynamics in self-organization of tissue architecture
- (2013) Yoshiki Sasai NATURE
- Vascularized and functional human liver from an iPSC-derived organ bud transplant
- (2013) Takanori Takebe et al. NATURE
- Cerebral organoids model human brain development and microcephaly
- (2013) Madeline A. Lancaster et al. NATURE
- Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
- (2013) Hiroko Koike-Yusa et al. NATURE BIOTECHNOLOGY
- Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
- (2013) Seung Woo Cho et al. NATURE BIOTECHNOLOGY
- High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
- (2013) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
- (2013) Andrew S Lee et al. NATURE MEDICINE
- RNA-guided gene activation by CRISPR-Cas9–based transcription factors
- (2013) Pablo Perez-Pinera et al. NATURE METHODS
- Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro
- (2013) Akihito Tanaka et al. PLoS One
- Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells
- (2013) M. Koyanagi-Aoi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex
- (2013) T. Kadoshima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of pluripotent stem cell-derived teratoma formation by small molecules
- (2013) M.-O. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
- (2013) P. Hou et al. SCIENCE
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Functional Preclinical Safety Assays
- (2013) Kate Harris et al. TOXICOLOGICAL SCIENCES
- Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes
- (2013) Kimberly R. Doherty et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells
- (2013) Grace Woodruff et al. Cell Reports
- RNA-programmed genome editing in human cells
- (2013) Martin Jinek et al. eLife
- APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation
- (2013) Jerome Mertens et al. Stem Cell Reports
- Reprogramming cell fates: insights from combinatorial approaches
- (2012) Carlos-Filipe Pereira et al. Annals of the New York Academy of Sciences
- Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay
- (2012) Susanne Höing et al. Cell Stem Cell
- Expanding the Boundaries of Embryonic Stem Cells
- (2012) Uri Ben-David et al. Cell Stem Cell
- Induced Pluripotent Stem Cells: Past, Present, and Future
- (2012) Shinya Yamanaka Cell Stem Cell
- Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs
- (2012) Tokushige Nakano et al. Cell Stem Cell
- Strategy for the creation of clinical grade hESC line banks that HLA-match a target population
- (2012) Laureen Jacquet et al. EMBO Molecular Medicine
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
- (2012) Adriana Sánchez-Danés et al. EMBO Molecular Medicine
- Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
- (2012) Guang-Hui Liu et al. NATURE
- Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression
- (2012) Gabsang Lee et al. NATURE BIOTECHNOLOGY
- A transcription activator-like effector toolbox for genome engineering
- (2012) Neville E Sanjana et al. Nature Protocols
- Genetic and epigenetic stability of human pluripotent stem cells
- (2012) Riikka J. Lund et al. NATURE REVIEWS GENETICS
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
- (2012) N. Egawa et al. Science Translational Medicine
- Pluripotent Stem Cells: Immune to the Immune System?
- (2012) J. I. Pearl et al. Science Translational Medicine
- Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
- (2012) O. Cooper et al. Science Translational Medicine
- Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events
- (2012) Xiaohong Xu et al. Stem Cell Research
- Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
- (2012) Houbo Jiang et al. Nature Communications
- Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
- (2012) Yoichi Imaizumi et al. Molecular Brain
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
- (2011) Ha Nam Nguyen et al. Cell Stem Cell
- Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells
- (2011) Ori Bar-Nur et al. Cell Stem Cell
- Short-Term Immunosuppression Promotes Engraftment of Embryonic and Induced Pluripotent Stem Cells
- (2011) Jeremy I. Pearl et al. Cell Stem Cell
- Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs
- (2011) Norikatsu Miyoshi et al. Cell Stem Cell
- The Use of Induced Pluripotent Stem Cells in Drug Development
- (2011) H Inoue et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Modeling familial Alzheimer's disease with induced pluripotent stem cells
- (2011) Takuya Yagi et al. HUMAN MOLECULAR GENETICS
- Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells
- (2011) Kazim H. Narsinh et al. JOURNAL OF CLINICAL INVESTIGATION
- Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells
- (2011) P. Seibler et al. JOURNAL OF NEUROSCIENCE
- Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction
- (2011) Kazuo Takayama et al. MOLECULAR THERAPY
- Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue
- (2011) Yongfang Zhao et al. NATURE
- Modelling schizophrenia using human induced pluripotent stem cells
- (2011) Kristen J. Brennand et al. NATURE
- Genetic engineering of human pluripotent cells using TALE nucleases
- (2011) Dirk Hockemeyer et al. NATURE BIOTECHNOLOGY
- Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells
- (2011) Kitai Kim et al. NATURE BIOTECHNOLOGY
- Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
- (2011) Amanda M Haidet-Phillips et al. NATURE BIOTECHNOLOGY
- Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
- (2011) Yuki Ohi et al. NATURE CELL BIOLOGY
- A more efficient method to generate integration-free human iPS cells
- (2011) Keisuke Okita et al. NATURE METHODS
- RNA-Seq of Human Neurons Derived from iPS Cells Reveals Candidate Long Non-Coding RNAs Involved in Neurogenesis and Neuropsychiatric Disorders
- (2011) Mingyan Lin et al. PLoS One
- Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
- (2011) Michael J. Devine et al. Nature Communications
- Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
- (2010) Luigi Warren et al. Cell Stem Cell
- Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
- (2010) M. Christian et al. GENETICS
- Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
- (2010) Jason R. Spence et al. NATURE
- A nonviral minicircle vector for deriving human iPS cells
- (2010) Fangjun Jia et al. NATURE METHODS
- Noninvasive De novo Imaging of Human Embryonic Stem Cell-Derived Teratoma Formation
- (2009) F. Cao et al. CANCER RESEARCH
- Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins
- (2009) Dohoon Kim et al. Cell Stem Cell
- Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells
- (2009) Jizhong Zou et al. Cell Stem Cell
- Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
- (2009) Gabsang Lee et al. NATURE
- piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
- (2009) Knut Woltjen et al. NATURE
- Variation in the safety of induced pluripotent stem cell lines
- (2009) Kyoko Miura et al. NATURE BIOTECHNOLOGY
- Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
- (2009) Dirk Hockemeyer et al. NATURE BIOTECHNOLOGY
- Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
- (2009) Noemi FUSAKI et al. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences
- (2009) J. Yu et al. SCIENCE
- Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines
- (2008) H R Lu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells
- (2008) Maria C.N. Marchetto et al. Cell Stem Cell
- Does Retroviral Insertional Mutagenesis Play a Role in the Generation of Induced Pluripotent Stem Cells?
- (2008) Robert G Hawley MOLECULAR THERAPY
- Induced pluripotent stem cells from a spinal muscular atrophy patient
- (2008) Allison D. Ebert et al. NATURE
- Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts
- (2008) R.-J. Swijnenburg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state
- (2008) S.-L. Lin et al. RNA
- Induced Pluripotent Stem Cells Generated Without Viral Integration
- (2008) M. Stadtfeld et al. SCIENCE
- Immunosuppression by Embryonic Stem Cells
- (2007) Cody A. Koch et al. STEM CELLS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now