标题
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
作者
关键词
-
出版物
NATURE
Volume 491, Issue 7425, Pages 603-607
出版商
Springer Nature
发表日期
2012-10-16
DOI
10.1038/nature11557
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
- (2012) Iakov N Rudenko et al. BMC Medicine
- A mutation in VAPB that causes amyotrophic lateral sclerosis also causes a nuclear envelope defect
- (2012) Duvinh Tran et al. JOURNAL OF CELL SCIENCE
- Lower cognitive performance in healthy G2019S LRRK2 mutation carriers
- (2012) A. Thaler et al. NEUROLOGY
- Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs
- (2011) Mo Li et al. CELL RESEARCH
- Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs
- (2011) Guang-Hui Liu et al. Cell Stem Cell
- Clinical and Pathological Characteristics of LRRK2 G2019S Patients with PD
- (2011) Markos Poulopoulos et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death
- (2011) Kuei-Hua Chang et al. MOLECULAR BIOLOGY OF THE CELL
- Efficient and Accurate Homologous Recombination in hESCs and hiPSCs Using Helper-dependent Adenoviral Vectors
- (2011) Emi Aizawa et al. MOLECULAR THERAPY
- Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome
- (2011) Guang-Hui Liu et al. NATURE
- Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
- (2011) Xianming Deng et al. Nature Chemical Biology
- Diseases in a dish: modeling human genetic disorders using induced pluripotent cells
- (2011) Gustavo Tiscornia et al. NATURE MEDICINE
- Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
- (2011) W. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
- (2011) V. Krishnan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization
- (2010) Nicolas Dzamko et al. BIOCHEMICAL JOURNAL
- 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
- (2010) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila
- (2010) Tomoko Kanao et al. HUMAN MOLECULAR GENETICS
- Parkinson's disease: insights from pathways
- (2010) M. R. Cookson et al. HUMAN MOLECULAR GENETICS
- Proteasome inhibition modeling nigral neuron degeneration in Parkinson’s disease
- (2010) Wenjie Xie et al. JOURNAL OF NEUROCHEMISTRY
- Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
- (2010) Stephan Gehrke et al. NATURE
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice
- (2010) B. Winner et al. NEUROBIOLOGY OF DISEASE
- Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex
- (2010) I. Cheung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Diseases of the Nuclear Envelope
- (2010) H. J. Worman et al. Cold Spring Harbor Perspectives in Biology
- Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
- (2008) T. Dechat et al. GENES & DEVELOPMENT
- Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors
- (2008) K. Suzuki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started