Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Functional Preclinical Safety Assays

The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells

(2012) Christopher Rao et al.   BIOMATERIALS

Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?

(2012) Hua Rong Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

(2012) Tao Yang et al.   CIRCULATION RESEARCH

Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: A blinded validation

(2012) Tengxian Liu et al.   HEART RHYTHM

The determination and interpretation of the therapeutic index in drug development

(2012) Patrick Y. Muller et al.   NATURE REVIEWS DRUG DISCOVERY

How do the top 12 pharmaceutical companies operate safety pharmacology?

(2012) Lorna Ewart et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents

(2011) Junyi Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

On the relationship between block of the cardiac Na+channel and drug-induced prolongation of the QRS complex

(2011) AR Harmer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models

(2011) Herbert M Himmel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

The Electrophysiological Effects of Cardiac Glycosides in Human iPSC-derived Cardiomyocytes and in Guinea Pig Isolated Hearts

(2011) Liang Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Opportunities for Use of Human iPS Cells in Predictive Toxicology

(2011) B D Anson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models

(2011) Udo Kraushaar et al.   Expert Opinion On Drug Safety

Drug-Induced QTC Prolongation Dangerously Underestimates Proarrhythmic Potential: Lessons From Terfenadine

(2011) Luc M Hondeghem et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2011) Liang Guo et al.   TOXICOLOGICAL SCIENCES

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

(2010) Shengde Peng et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical

(2010) B.M. Heath et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

On the Road to iPS Cell Cardiovascular Applications

(2009) Timothy J. Kamp et al.   CIRCULATION RESEARCH

Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its β1 subunit

(2009) Victor A. Maltsev et al.   Journal of Physiological Sciences

A framework to assess the translation of safety pharmacology data to humans

(2009) Jean-Pierre Valentin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Safety and secondary pharmacology: Successes, threats, challenges and opportunities

(2008) Jean-Pierre Valentin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS