Rodent models for Alzheimer’s disease drug discovery

Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds

(2016) Diana L. Castillo-Carranza et al.   JOURNAL OF ALZHEIMERS DISEASE

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study

(2015) Leanne M. Stevens et al.   BEHAVIOURAL BRAIN RESEARCH

Acute Oral Bryostatin-1 Administration Improves Learning Deficits in the APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease

(2015) L.M. Schrott et al.   Current Alzheimer Research

Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice

(2015) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease

(2015) Dan Xia et al.   NEURON

In Vivo Application of beta Amyloid Oligomers: A Simple Tool to Evaluate Mechanisms of Action and New Therapeutic Approaches

(2015) Claudia Balducci et al.   CURRENT PHARMACEUTICAL DESIGN

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

(2014) Daniela Puzzo et al.   BIOCHEMICAL PHARMACOLOGY

Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer’s disease

(2014) Giuseppina Cantarella et al.   BRAIN

Lamotrigine attenuates deficits in synaptic plasticity and accumulation of amyloid plaques in APP/PS1 transgenic mice

(2014) Mao-Ying Zhang et al.   NEUROBIOLOGY OF AGING

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

(2014) Syed Faraz Kazim et al.   NEUROBIOLOGY OF DISEASE

Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice

(2014) M.Y. Liu et al.   NEUROSCIENCE

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

(2013) Junfang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Animal Models of Aging: Something Old, Something New

(2013) R. L. Sprott   ILAR JOURNAL

Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease

(2013) Kenghoe Lok et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

(2013) Rocio Perez-Gonzalez et al.   NEUROBIOLOGY OF AGING

Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

(2013) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

(2013) A.S.R. Sierksma et al.   NEUROPHARMACOLOGY

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

(2013) D. Martin Watterson et al.   PLoS One

Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory

(2012) Agostino Palmeri et al.   BEHAVIOURAL BRAIN RESEARCH

Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

(2012) Jole Fiorito et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice

(2012) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into CNS ageing from animal models of senescence

(2012) Mark Yeoman et al.   NATURE REVIEWS NEUROSCIENCE

Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory

(2012) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

Hippocampal calbindin-1 immunoreactivity correlate of recognition memory performance in aged mice

(2012) Virawudh Soontornniyomkij et al.   NEUROSCIENCE LETTERS

Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice

(2011) T. A. Bedrosian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular oligomeric tau inhibits memory formation in mice

(2010) James G. Moe et al.   Alzheimers & Dementia

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

(2010) Daniela Puzzo et al.   ANNALS OF NEUROLOGY

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Spatial and emotional memory in aged rats: a behavioral-statistical analysis

(2010) J.A. Bergado et al.   NEUROSCIENCE

Modulation of synaptic function by extracellular tau enriched in oligomers

(2009) James G. Moe et al.   Alzheimers & Dementia

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-  Load in an Alzheimer's Disease Mouse Model

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE

Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging

(2009) Wei Wang et al.   LIFE SCIENCES

Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade

(2009) Q. Li et al.   NEUROSCIENCE

Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease

(2009) Lisa Placanica et al.   PLoS One

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.

(2008) Susanna Pietropaolo et al.   BEHAVIORAL NEUROSCIENCE

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

(2008) Fabrizio Trinchese et al.   JOURNAL OF CLINICAL INVESTIGATION

Decreased Presence of Perforated Synapses in a Triple-Transgenic Mouse Model of Alzheimer's Disease

(2008) Carlo Bertoni-Freddari et al.   REJUVENATION RESEARCH