Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons

Parkinson's disease in a dish – Using stem cells as a molecular tool

(2013) J.L. Badger et al.   NEUROPHARMACOLOGY

Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons

(2013) Maria Sundberg et al.   STEM CELLS

Modeling Parkinson's Disease in Primates: The MPTP Model

(2013) G. Porras et al.   Cold Spring Harbor Perspectives in Medicine

Lmx1b can promote the differentiation of embryonic stem cells to dopaminergic neurons associated with Parkinson’s disease

(2012) Li-Peng Tian et al.   BIOTECHNOLOGY LETTERS

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease

(2012) D. James Surmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area

(2012) Stefanie Reyes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

(2012) Rickie Patani et al.   JOURNAL OF NEUROCHEMISTRY

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

In Vitro Maturation of Dopaminergic Neurons Derived from Mouse Embryonic Stem Cells: Implications for Transplantation

(2012) Bradley Watmuff et al.   PLoS One

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

(2012) Houbo Jiang et al.   Nature Communications

The endo-lysosomal system as an NAADP-sensitive acidic Ca2+ store: Role for the two-pore channels

(2011) Sandip Patel et al.   CELL CALCIUM

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

(2011) Shengnan Wu et al.   FEBS Journal

Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease

(2011) Yong-Hee Rhee et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

Copy number variation and selection during reprogramming to pluripotency

(2011) Samer M. Hussein et al.   NATURE

A bioinformatic assay for pluripotency in human cells

(2011) Franz-Josef Müller et al.   NATURE METHODS

ROCK Inhibitor Y-27632 Suppresses Dissociation-Induced Apoptosis of Murine Prostate Stem/Progenitor Cells and Increases Their Cloning Efficiency

(2011) Li Zhang et al.   PLoS One

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

(2011) Blake Byers et al.   PLoS One

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

(2010) Dalton James Surmeier et al.   ANTIOXIDANTS & REDOX SIGNALING

Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease

(2010) D. James Surmeier et al.   CELL CALCIUM

A Call to Standardize Teratoma Assays Used to Define Human Pluripotent Cell Lines

(2010) Franz-Josef Müller et al.   Cell Stem Cell

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid

(2010) Oliver Cooper et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Human Stem Cell-Derived Neurons: A System to Study Human Tau Function and Dysfunction

(2010) Mariangela Iovino et al.   PLoS One

An Improved Technique for Chromosomal Analysis of Human ES and iPS Cells

(2010) Daniela Moralli et al.   Stem Cell Reviews and Reports

Robust Pacemaking in Substantia Nigra Dopaminergic Neurons

(2009) J. N. Guzman et al.   JOURNAL OF NEUROSCIENCE

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells

(2009) Elayne M Chan et al.   NATURE BIOTECHNOLOGY

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells Survive and Integrate into 6-OHDA-Lesioned Rats

(2009) Jingli Cai et al.   STEM CELLS AND DEVELOPMENT

Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells

(2008) M. S. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors

(2007) Masaomi Koyanagi et al.   JOURNAL OF NEUROSCIENCE RESEARCH