标题
Evolution of strategies to improve preclinical cardiac safety testing
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 15, Issue 7, Pages 457-471
出版商
Springer Nature
发表日期
2016-02-19
DOI
10.1038/nrd.2015.34
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro – Correlation between contraction force and electrophysiology
- (2015) Marcelo C. Ribeiro et al. BIOMATERIALS
- Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury
- (2015) M J Cross et al. BRITISH JOURNAL OF PHARMACOLOGY
- Role of Sodium and Calcium Dysregulation in Tachyarrhythmias in Sudden Cardiac Death
- (2015) S. Wagner et al. CIRCULATION RESEARCH
- Cell-Specific Cardiac Electrophysiology Models
- (2015) Willemijn Groenendaal et al. PLoS Computational Biology
- Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
- (2015) J.-i. Okada et al. Science Advances
- Action Potential Characterization of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Using Automated Patch-Clamp Technology
- (2014) Olaf Scheel et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Effect of Terfenadine and Pentamidine on the hERG Channel and Its Intracellular Trafficking: Combined Analysis with Automated Voltage Clamp and Confocal Microscopy
- (2014) Hikaru Tanaka et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Electrophysiologic Substrate in Congenital Long QT Syndrome
- (2014) Ramya Vijayakumar et al. CIRCULATION
- Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability
- (2014) Tao Yang et al. CIRCULATION
- Engineering Adolescence
- (2014) Xiulan Yang et al. CIRCULATION RESEARCH
- Measuring the Contractile Forces of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Arrays of Microposts
- (2014) Marita L. Rodriguez et al. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
- In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome
- (2014) Lucia Romero et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation
- (2014) Marc N. Hirt et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell–Derived Cardiomyocyte Sheet: Multi-site Validation Study
- (2014) Yuji Nakamura et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Simulation of early after-depolarisation in non-failing human ventricular myocytes: Can this help cardiac safety pharmacology?
- (2014) Bernard Christophe Pharmacological Reports
- A Quantitative Comparison of the Behavior of Human Ventricular Cardiac Electrophysiology Models in Tissue
- (2014) Mohamed M. Elshrif et al. PLoS One
- A Study of Early Afterdepolarizations in a Model for Human Ventricular Tissue
- (2014) Nele Vandersickel et al. PLoS One
- High-Throughput Multi-Parameter Profiling of Electrophysiological Drug Effects in Human Embryonic Stem Cell Derived Cardiomyocytes Using Multi-Electrode Arrays
- (2014) Mike Clements et al. TOXICOLOGICAL SCIENCES
- Myocardial Tissue Engineering: In Vitro Models
- (2014) G. Vunjak Novakovic et al. Cold Spring Harbor Perspectives in Medicine
- Prediction of Thorough QT study results using action potential simulations based on ion channel screens
- (2014) Gary R. Mirams et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents
- (2014) John K. Gibson et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Early identification of hERG liability in drug discovery programs by automated patch clamp
- (2014) Timm Danker et al. Frontiers in Pharmacology
- Quality Metrics for Stem Cell-Derived Cardiac Myocytes
- (2014) Sean P. Sheehy et al. Stem Cell Reports
- Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium
- (2013) Philip T. Sager et al. AMERICAN HEART JOURNAL
- Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype
- (2013) Christine Y. Ivashchenko et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Identifying the translational gap in the evaluation of drug-induced QTcinterval prolongation
- (2013) Anne S.Y. Chain et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve
- (2013) Zhilin Qu et al. CARDIOVASCULAR RESEARCH
- In silico assessment of drug safety in human heart applied to late sodium current blockers
- (2013) Beatriz Trenor et al. Channels
- Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays
- (2013) E. G. Navarrete et al. CIRCULATION
- Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity
- (2013) Ping Liang et al. CIRCULATION
- Ranolazine for Congenital and Acquired Late I Na -Linked Arrhythmias
- (2013) Jonathan D. Moreno et al. CIRCULATION RESEARCH
- Dealing with Global Safety Issues
- (2013) Norman Stockbridge et al. DRUG SAFETY
- Mechanistic basis of excitation-contraction coupling in human pluripotent stem cell-derived ventricular cardiomyocytes revealed by Ca2+ spark characteristics: Direct evidence of functional Ca2+-induced Ca2+ release
- (2013) Sen Li et al. HEART RHYTHM
- hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment
- (2013) GIOVANNI Y. DI VEROLI et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- Lessons from the heart: Mirroring electrophysiological characteristics during cardiac development to in vitro differentiation of stem cell derived cardiomyocytes
- (2013) Nikki H.L. van den Heuvel et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram
- (2013) Arash Sadrieh et al. JOURNAL OF PHYSIOLOGY-LONDON
- Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs
- (2013) Norbert Jost et al. JOURNAL OF PHYSIOLOGY-LONDON
- Calcium signalling of human pluripotent stem cell-derived cardiomyocytes
- (2013) Sen Li et al. JOURNAL OF PHYSIOLOGY-LONDON
- Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
- (2013) Sara S Nunes et al. NATURE METHODS
- Revolution dawning in cardiotoxicity testing
- (2013) Kelly Rae Chi NATURE REVIEWS DRUG DISCOVERY
- Small and large animal models in cardiac contraction research: Advantages and disadvantages
- (2013) Nima Milani-Nejad et al. PHARMACOLOGY & THERAPEUTICS
- Identification and Characterization of Calcium Sparks in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
- (2013) Guang Qin Zhang et al. PLoS One
- Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes
- (2013) Claire Robertson et al. STEM CELLS
- Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells
- (2013) Scott D. Lundy et al. STEM CELLS AND DEVELOPMENT
- Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model
- (2013) Liang Guo et al. TOXICOLOGICAL SCIENCES
- Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity
- (2013) Amy Pointon et al. TOXICOLOGICAL SCIENCES
- Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Functional Preclinical Safety Assays
- (2013) Kate Harris et al. TOXICOLOGICAL SCIENCES
- Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes
- (2013) Kimberly R. Doherty et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Human induced pluripotent stem cells and their use in drug discovery for toxicity testing
- (2013) Clay W Scott et al. TOXICOLOGY LETTERS
- MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
- (2013) James Kramer et al. Scientific Reports
- Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay
- (2013) Yusheng Qu et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- A high content screening assay to predict human drug-induced liver injury during drug discovery
- (2013) Mikael Persson et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- A history of the role of the hERG channel in cardiac risk assessment
- (2013) David Rampe et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge
- (2013) Kylie A. Beattie et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis
- (2013) Jordi Heijman et al. PLoS Computational Biology
- Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias
- (2013) Hrayr S. Karagueuzian et al. Frontiers in Physiology
- High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment
- (2012) Giovanni Y. Di Veroli et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Current status of drug screening and disease modelling in human pluripotent stem cells
- (2012) Divya Rajamohan et al. BIOESSAYS
- The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells
- (2012) Christopher Rao et al. BIOMATERIALS
- Dynamics of Early Afterdepolarization-Mediated Triggered Activity in Cardiac Monolayers
- (2012) Marvin G. Chang et al. BIOPHYSICAL JOURNAL
- Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing
- (2012) Gary R Mirams et al. BRITISH JOURNAL OF PHARMACOLOGY
- Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials
- (2012) Nejib Zemzemi et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease
- (2012) Richard P. Davis et al. CIRCULATION
- HTS techniques for patch clamp-based ion channel screening – advances and economy
- (2012) Cecilia Farre et al. Expert Opinion on Drug Discovery
- Antiarrhythmic properties of ranolazine – from bench to bedside
- (2012) Stylianos Tzeis et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG
- (2012) Malin K.B. Jonsson et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
- (2012) Joanne Bowes et al. NATURE REVIEWS DRUG DISCOVERY
- Diagnosing the decline in pharmaceutical R&D efficiency
- (2012) Jack W. Scannell et al. NATURE REVIEWS DRUG DISCOVERY
- Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations
- (2012) A. Corrias et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- hERG K+ Channels: Structure, Function, and Clinical Significance
- (2012) Jamie I. Vandenberg et al. PHYSIOLOGICAL REVIEWS
- Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells
- (2012) Adriana Blazeski et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Repolarization gradients in the intact heart: Transmural or apico-basal?
- (2012) Michiel J. Janse et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Contractile Properties of Early Human Embryonic Stem Cell-Derived Cardiomyocytes: Beta-Adrenergic Stimulation Induces Positive Chronotropy and Lusitropy but Not Inotropy
- (2012) Frank Pillekamp et al. STEM CELLS AND DEVELOPMENT
- Development of High Content Imaging Methods for Cell Death Detection in Human Pluripotent Stem Cell-Derived Cardiomyocytes
- (2012) Maxime Mioulane et al. Journal of Cardiovascular Translational Research
- In Vitro Uses of Human Pluripotent Stem Cell-Derived Cardiomyocytes
- (2012) Elena Matsa et al. Journal of Cardiovascular Translational Research
- Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias
- (2012) Maaike Hoekstra et al. Frontiers in Physiology
- High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents
- (2011) Junyi Ma et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species
- (2011) Thomas O'Hara et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk
- (2011) András Varró et al. BRITISH JOURNAL OF PHARMACOLOGY
- Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk
- (2011) Gary R. Mirams et al. CARDIOVASCULAR RESEARCH
- Heart Failure Associated with Sunitinib: Lessons Learned from Animal Models
- (2011) Colin F. Greineder et al. CURRENT HYPERTENSION REPORTS
- Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models
- (2011) Udo Kraushaar et al. Expert Opinion On Drug Safety
- Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis
- (2011) Amrita X. Sarkar et al. HEART RHYTHM
- Metabolic stress, reactive oxygen species, and arrhythmia
- (2011) Euy-Myoung Jeong et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Electrophysiological Characterization of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
- (2011) Masaki Honda et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
- (2011) Yee-Ki Lee et al. Stem Cell Reviews and Reports
- Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation
- (2011) Thomas O'Hara et al. PLoS Computational Biology
- Screening Action Potentials: The Power of Light
- (2011) Lars Kaestner et al. Frontiers in Pharmacology
- Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening
- (2010) Emily Dick et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Comparison of contractile behavior of native murine ventricular tissue and cardiomyocytes derived from embryonic or induced pluripotent stem cells
- (2010) Jiaoya Xi et al. FASEB JOURNAL
- Protein Binding-dependent Decreases in hERG Channel Blocker Potency Assessed by Whole-Cell Voltage Clamp in Serum
- (2010) Michael Margulis et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Modulation of cardiac ERG1 K+ channels by cGMP signaling
- (2010) Marco Mewe et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Drug-Induced Long QT Syndrome
- (2010) P. Kannankeril et al. PHARMACOLOGICAL REVIEWS
- An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation
- (2010) Gary Gintant PHARMACOLOGY & THERAPEUTICS
- Why do Kinase Inhibitors Cause Cardiotoxicity and What can be Done About It?
- (2010) Hui Cheng et al. PROGRESS IN CARDIOVASCULAR DISEASES
- Cardiotoxicity Associated with Targeting Kinase Pathways in Cancer
- (2010) Howard R. Mellor et al. TOXICOLOGICAL SCIENCES
- The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro
- (2010) Brian B. Hasinoff et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes
- (2010) Shengde Peng et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37°C: Cisapride versus dofetilide
- (2010) James T. Milnes et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells
- (2010) Amrita X. Sarkar et al. PLoS Computational Biology
- Stereoselective Inhibition of the hERG1 Potassium Channel
- (2010) Liliana Sintra Grilo et al. Frontiers in Pharmacology
- Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na+ current in the heart
- (2009) Lin Wu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Impact of ionic current variability on human ventricular cellular electrophysiology
- (2009) Lucía Romero et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Integrated risk assessment and predictive value to humans of non-clinical repolarization assays
- (2009) Robert M Wallis BRITISH JOURNAL OF PHARMACOLOGY
- Safety Pharmacology Society: 8th annual meeting
- (2009) Icilio Cavero Expert Opinion On Drug Safety
- Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells
- (2009) Igal Germanguz et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- HERG1 channelopathies
- (2009) Michael C. Sanguinetti PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes
- (2009) Stefan R. Braam et al. Stem Cell Research
- Absence of Transverse Tubules Contributes to Non-Uniform Ca2+ Wavefronts in Mouse and Human Embryonic Stem Cell–Derived Cardiomyocytes
- (2009) Deborah K. Lieu et al. STEM CELLS AND DEVELOPMENT
- Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes
- (2008) P T Sager BRITISH JOURNAL OF PHARMACOLOGY
- Cellular basis of drug-induced torsades de pointes
- (2008) D M Roden BRITISH JOURNAL OF PHARMACOLOGY
- Collation, assessment and analysis of literaturein vitrodata on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties
- (2008) Sebastian Polak et al. JOURNAL OF APPLIED TOXICOLOGY
- Benchmarking Safety Pharmacology regulatory packages and best practice
- (2008) Silvana Lindgren et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Test article concentrations in the hERG assay: Losses through the perfusion, solubility and stability
- (2008) Jessica C. Brimecombe et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started