Egress of resident memory T cells from tissue with neoadjuvant immunotherapy: Implications for systemic anti-tumor immunity

The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8+ T cell differentiation and function

(2023) Joseph W. Dean et al.   Cell Reports

Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T cells following neoadjuvant immunotherapy in head and neck cancer

(2023) Cem Sievers et al.   CANCER CELL

Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

(2023) Balaji Virassamy et al.   CANCER CELL

Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion

(2023) Elena Battistello et al.   MOLECULAR CELL

T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control

(2023) Maria M. Steele et al.   NATURE IMMUNOLOGY

Chronic antigen in solid tumors drives a distinct program of T cell residence

(2023) Noah V. Gavil et al.   Science Immunology

Deep Immune Phenotyping and Single-Cell Transcriptomics Allow Identification of Circulating TRM-Like Cells Which Correlate With Liver-Stage Immunity and Vaccine-Induced Protection From Malaria

(2022) Andrés Noé et al.   Frontiers in Immunology

T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma

(2022) Maryam Barsch et al.   JOURNAL OF HEPATOLOGY

‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses

(2022) Dietmar Zehn et al.   NATURE IMMUNOLOGY

Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma

(2022) Jeppe Sejerø Holm et al.   Nature Communications

Tissue-resident memory T cells from a metastatic vaginal melanoma patient are tumor-responsive T cells and increase after anti-PD-1 treatment

(2022) Angela Pizzolla et al.   Journal for ImmunoTherapy of Cancer

Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?

(2022) Andrea Aran et al.   Cancers

Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy

(2022) Adrienne M. Luoma et al.   CELL

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

(2022) John T. Crowl et al.   NATURE IMMUNOLOGY

Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells

(2022) Raíssa Fonseca et al.   NATURE IMMUNOLOGY

Higher proportions of CD39+ tumor-resident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy

(2022) Grace Heloise Attrill et al.   Journal for ImmunoTherapy of Cancer

Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood

(2022) Jennifer Wilkinson Carlisle et al.   Journal for ImmunoTherapy of Cancer

TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection

(2022) Yinghong Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β promotes stem-like T cells via enforcing their lymphoid tissue retention

(2022) Chaoyu Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine

(2022) Guo Li et al.   Nature Communications

Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

(2022) Yun Hsuan Lin et al.   IMMUNITY

CD103 fate mapping reveals that intestinal CD103 − tissue-resident memory T cells are the primary responders to secondary infection

(2022) Helen Y. Fung et al.   Science Immunology

Key chemokines direct migration of immune cells in solid tumors

(2021) Karan Kohli et al.   CANCER GENE THERAPY

Resident memory T cells in tumor-distant tissues fortify against metastasis formation

(2021) Laura S. Christian et al.   Cell Reports

Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma

(2021) Aleksey K. Molodtsov et al.   IMMUNITY

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

(2021) Susan N. Christo et al.   NATURE IMMUNOLOGY

Tumour antigen-induced T cell exhaustion — the archenemy of immune-hot malignancies

(2021) Miguel Lopez de Rodas et al.   Nature Reviews Clinical Oncology

The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

(2021) Sara Valpione et al.   Nature Communications

A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response

(2021) Kelli A. Connolly et al.   Science Immunology

Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes

(2021) Loreto Parga-Vidal et al.   Science Immunology

Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation

(2021) Johanna Strobl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human mucosal tissue-resident memory T cells in health and disease

(2021) Joshua Lange et al.   Mucosal Immunology

Developmental plasticity allows outside-in immune responses by resident memory T cells

(2020) Raissa Fonseca et al.   NATURE IMMUNOLOGY

PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection

(2020) Se Jin Im et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy

(2020) J. Justin Milner et al.   IMMUNITY

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

(2020) Cristina Ferreira et al.   NATURE IMMUNOLOGY

CD244 represents a new therapeutic target in head and neck squamous cell carcinoma

(2020) Laura Agresta et al.   Journal for ImmunoTherapy of Cancer

Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

(2020) Nadia S. Kurd et al.   Science Immunology

The SKI proto-oncogene restrains the resident CD103+CD8+ T cell response in viral clearance

(2020) Bing Wu et al.   Cellular & Molecular Immunology

A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool

(2020) Lianne Kok et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

(2020) Felix M. Behr et al.   NATURE IMMUNOLOGY

Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer

(2020) Takemasa Tsuji et al.   Oncotarget

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

(2020) Hans Raskov et al.   BRITISH JOURNAL OF CANCER

CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

(2020) Shannon K. Bromley et al.   Cell Reports

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

(2020) Joel Kidman et al.   Frontiers in Immunology

Comparative analysis reveals a role for TGF-β in shaping the residency-related transcriptional signature in tissue-resident memory CD8+ T cells

(2019) Artika P. Nath et al.   PLoS One

Mobilization of CD8+ T Cells via CXCR4 Blockade Facilitates PD-1 Checkpoint Therapy in Human Pancreatic Cancer

(2019) Yongwoo David Seo et al.   CLINICAL CANCER RESEARCH

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location

(2019) Daniel A. Walsh et al.   JOURNAL OF IMMUNOLOGY

Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-β Release

(2019) Elizabeth A. Thompson et al.   Cell Reports

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

(2019) Maria M. Klicznik et al.   Science Immunology

CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

(2019) Alexander N. Wein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate

(2019) Vinidhra Mani et al.   SCIENCE

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

(2019) Peter A. Szabo et al.   Nature Communications

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

(2019) Caroline S. Jansen et al.   NATURE

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

(2018) Lalit K. Beura et al.   IMMUNITY

Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia

(2018) Erika Tissino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin

(2018) Michelle L. McCully et al.   JOURNAL OF IMMUNOLOGY

Beyond migration-Chemokines in lymphocyte priming, differentiation, and modulating effector functions

(2018) Julia M. Laufer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

(2018) Simone L. Park et al.   NATURE IMMUNOLOGY

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

(2018) Peter Savas et al.   NATURE MEDICINE

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

The Emerging Role of CD8+ Tissue Resident Memory T (TRM) Cells in Antitumor Immunity: A Unique Functional Contribution of the CD103 Integrin

(2018) Stéphanie Corgnac et al.   Frontiers in Immunology

Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration

(2018) Laura Megrelis et al.   Frontiers in Immunology

GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation

(2018) Kuan-Lun Chu et al.   Mucosal Immunology

CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

(2017) Stanley Cheuk et al.   IMMUNITY

Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung

(2017) A C Zhou et al.   Mucosal Immunology

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Chromatin states define tumour-specific T cell dysfunction and reprogramming

(2017) Mary Philip et al.   NATURE

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

(2017) Alice O. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Regulation of Tissue-Resident Lymphocytes

(2017) Laura K. Mackay et al.   TRENDS IN IMMUNOLOGY

Local Inflammatory Cues Regulate Differentiation and Persistence of CD8 + Tissue-Resident Memory T Cells

(2017) Tessa Bergsbaken et al.   Cell Reports

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

Local antigen in nonlymphoid tissue promotes resident memory CD8+T cell formation during viral infection

(2016) Tahsin N. Khan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation

(2016) Chaoyu Ma et al.   JOURNAL OF IMMUNOLOGY

A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet

(2016) Annie Xin et al.   NATURE IMMUNOLOGY

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

(2016) Javed Mohammed et al.   NATURE IMMUNOLOGY

Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence

(2016) Abhirami A. Ananth et al.   PLoS One

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

(2016) A. Pasetto et al.   Cancer Immunology Research

Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans

(2015) Felipe A. Vieira Braga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

(2015) Fayçal Djenidi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

(2015) Laura K. Mackay et al.   JOURNAL OF IMMUNOLOGY

Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection

(2015) Tessa Bergsbaken et al.   NATURE IMMUNOLOGY

Common clonal origin of central and resident memory T cells following skin immunization

(2015) Olivier Gaide et al.   NATURE MEDICINE

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer

(2015) Qingzhu Jia et al.   OncoImmunology

Cutting Edge: CXCR4 Is Critical for CD8+ Memory T Cell Homeostatic Self-Renewal but Not Rechallenge Self-Renewal

(2014) J. Chaix et al.   JOURNAL OF IMMUNOLOGY

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

(2013) Daniel T Utzschneider et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

The Impact of KLF2 Modulation on the Transcriptional Program and Function of CD8 T Cells

(2013) Gavin C. Preston et al.   PLoS One

Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells

(2012) L.-H. Tai et al.   CANCER RESEARCH

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

A vaccine strategy that protects against genital herpes by establishing local memory T cells

(2012) Haina Shin et al.   NATURE

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

(2012) S. Ariotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44

(2012) Bas J. G. Baaten et al.   Frontiers in Immunology

The Role of Chemokines in the Recruitment of Lymphocytes to the Liver

(2010) Ye H. Oo et al.   DIGESTIVE DISEASES

Adaptive immunity

(2010) Francisco A. Bonilla et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

One naive T cell, multiple fates in CD8+T cell differentiation

(2010) Carmen Gerlach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

KLRG1—more than a marker for T cell senescence

(2009) Sian M. Henson et al.   AGE

THE CHEMOKINE CXCL16 IS HIGHLY AND CONSTITUTIVELY EXPRESSED BY HUMAN BRONCHIAL EPITHELIAL CELLS

(2009) Caroline Day et al.   EXPERIMENTAL LUNG RESEARCH

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses

(2009) Axel Kallies et al.   IMMUNITY

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY