Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

CAR T cells: continuation in a revolution of immunotherapy

(2020) Anurag K Singh et al.   LANCET ONCOLOGY

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours

(2020) Elżbieta Chruściel et al.   Cancers

Enhancing anti-tumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors

(2019) K M Heinhuis et al.   ANNALS OF ONCOLOGY

WNT/β-catenin pathway activation correlates with immune exclusion across human cancers

(2019) Jason J. Luke et al.   CLINICAL CANCER RESEARCH

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

(2019) Fernando Souza-Fonseca-Guimaraes et al.   TRENDS IN IMMUNOLOGY

Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System

(2019) Shweta Joshi et al.   Journal of Oncology

T cell stemness and dysfunction in tumors are triggered by a common mechanism

(2019) Suman Kumar Vodnala et al.   SCIENCE

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

(2019) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

(2019) Mohamed-Reda Benmebarek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome-orchestrated hypoxic tumor microenvironment

(2019) Wanrong Meng et al.   Molecular Cancer

Anticancer autophagy inhibitors attract ‘resurgent’ interest

(2019) Elie Dolgin   NATURE REVIEWS DRUG DISCOVERY

Intrinsic β-catenin signaling suppresses CD8+ T-cell infiltration in colorectal cancer

(2019) Junli Xue et al.   BIOMEDICINE & PHARMACOTHERAPY

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

(2019) Bryan D. Choi et al.   NATURE BIOTECHNOLOGY

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

(2019) Lea Monteran et al.   Frontiers in Immunology

Cancer-Derived Exosomes as Effectors of Key Inflammation-Related Players

(2019) Norahayu Othman et al.   Frontiers in Immunology

Multiomics Prediction of Response Rates to Therapies to Inhibit Programmed Cell Death 1 and Programmed Cell Death 1 Ligand 1

(2019) Joo Sang Lee et al.   JAMA Oncology

The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors

(2019) Andrew A. Davis et al.   Journal for ImmunoTherapy of Cancer

Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

(2019) Jean M. Mulcahy Levy et al.   CELL DEATH AND DIFFERENTIATION

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

(2018) Miliotou N. Androulla et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Inducible Co-Stimulator (ICOS) as a potential therapeutic target for anti-cancer therapy

(2018) Florent Amatore et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Fludarabine and neurotoxicity in engineered T-cell therapy

(2018) Kate L. Lowe et al.   GENE THERAPY

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

(2018) Max D. Wellenstein et al.   IMMUNITY

Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer

(2018) Michael J. Overman et al.   JOURNAL OF CLINICAL ONCOLOGY

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

(2018) Margherita Norelli et al.   NATURE MEDICINE

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

(2018) Leena Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudoprogression and hyperprogression during immune checkpoint inhibitor therapy for urothelial and kidney cancer

(2018) Francesco Soria et al.   WORLD JOURNAL OF UROLOGY

Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells

(2018) Matthew A. Lakins et al.   Nature Communications

Genetic Mechanisms of Immune Evasion in Colorectal Cancer

(2018) Catherine S. Grasso et al.   Cancer Discovery

The Origin and Functions of Exosomes in Cancer

(2018) Chitra Rajagopal et al.   Frontiers in Oncology

Natural Killer Cell IFNγ Secretion is Profoundly Suppressed Following Colorectal Cancer Surgery

(2018) Leonard Angka et al.   ANNALS OF SURGICAL ONCOLOGY

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

(2018) Leora Horn et al.   NEW ENGLAND JOURNAL OF MEDICINE

The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies

(2018) Kerrie Faia et al.   PLoS One

CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease

(2018) Katherine C. Pehlivan et al.   Current Hematologic Malignancy Reports

T Cell–Inflamed versus Non-T Cell–Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection

(2018) Jonathan A. Trujillo et al.   Cancer Immunology Research

Metabolic Checkpoints: Novel Avenues for Immunotherapy of Cancer

(2018) Ivan Shevchenko et al.   Frontiers in Immunology

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

(2018) Hanjie Li et al.   CELL

Unique pattern of neutrophil migration and function during tumor progression

(2018) Sima Patel et al.   NATURE IMMUNOLOGY

Trial watch: The clinical trial landscape for PD1/PDL1 immune checkpoint inhibitors

(2018) Jun Tang et al.   NATURE REVIEWS DRUG DISCOVERY

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Developing combination strategies using PD-1 checkpoint inhibitors to treat cancer

(2018) Emmett V. Schmidt   Seminars in Immunopathology

Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer

(2018) Ewelina Grywalska et al.   OncoTargets and Therapy

The Potential for Cancer Immunotherapy in Targeting Surgery-Induced Natural Killer Cell Dysfunction

(2018) Marisa Market et al.   Cancers

Selected signalling proteins recruited to the T-cell receptor-CD3 complex

(2017) Jatuporn Ngoenkam et al.   IMMUNOLOGY

BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer

(2017) Shin-Heng Chiou et al.   Cancer Discovery

PD1 signal transduction pathways in T cells

(2017) Hugo Arasanz et al.   Oncotarget

Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells

(2017) Chad M. Williams et al.   Frontiers in Immunology

Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation

(2017) Sara Zumerle et al.   Frontiers in Immunology

Allogeneic Stem Cell Transplantation: A Historical and Scientific Overview

(2016) Anurag K. Singh et al.   CANCER RESEARCH

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

(2016) Qingshan Fu et al.   MOLECULAR CELL

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse

(2016) Roxana Khazen et al.   Nature Communications

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

(2016) P.-L. Chen et al.   Cancer Discovery

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

Exploiting the critical perioperative period to improve long-term cancer outcomes

(2015) Maya Horowitz et al.   Nature Reviews Clinical Oncology

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

(2015) Kristine N. Brazin et al.   Frontiers in Immunology

Phosphatase CD45 Both Positively and Negatively Regulates T Cell Receptor Phosphorylation in Reconstituted Membrane Protein Clusters

(2014) Gabriela Furlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Association of the CD3  Signaling Domain Is Required for Optimal T Cell Development and Function

(2014) M. L. Bettini et al.   JOURNAL OF IMMUNOLOGY

CD4+ /CD8+ double-positive T cells: more than just a developmental stage?

(2014) Nana H. Overgaard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels

(2014) Jacqueline Thorburn et al.   Cell Reports

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state

(2013) Delphine Garnier et al.   EXPERIMENTAL CELL RESEARCH

At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy

(2013) Andrew M. Intlekofer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer-associated fibroblasts as targets for immunotherapy

(2012) Sunitha Kakarla et al.   Immunotherapy

Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

(2012) J. M. Angelosanto et al.   JOURNAL OF VIROLOGY

In vivo gene transfer targeting in pancreatic adenocarcinoma with cell surface antigens

(2012) Marie Lafitte et al.   Molecular Cancer

Endocytosis by target cells: an essential means for perforin- and granzyme-mediated killing

(2011) Claire Gordy et al.   Cellular & Molecular Immunology

PD-1 Ligand Expression by Human Colonic Myofibroblasts/Fibroblasts Regulates CD4+ T-Cell Activity

(2008) Irina V. Pinchuk et al.   GASTROENTEROLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA