Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?
出版年份 2022 全文链接
标题
Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?
作者
关键词
-
出版物
Cancers
Volume 14, Issue 7, Pages 1771
出版商
MDPI AG
发表日期
2022-04-01
DOI
10.3390/cancers14071771
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers
- (2022) Frank J. Lowery et al. SCIENCE
- Early changes in the circulating T cells are associated with clinical outcomes after PD-L1 blockade by durvalumab in advanced NSCLC patients
- (2021) Elliot Naidus et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Mapping the functional landscape of T cell receptor repertoires by single-T cell transcriptomics
- (2021) Ze Zhang et al. NATURE METHODS
- Immune Aging and Immunotherapy in Cancer
- (2021) Melanie Kaiser et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Autoimmune Responses in Oncology: Causes and Significance
- (2021) Halin Bareke et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- High-throughput and single-cell T cell receptor sequencing technologies
- (2021) Joy A. Pai et al. NATURE METHODS
- Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy
- (2021) Anna Pasetto et al. Frontiers in Immunology
- Epigenetic Upregulation of MAGE-A Isoforms Promotes Breast Cancer Cell Aggressiveness
- (2021) Chaeun Oh et al. Cancers
- Distinct populations of antigen specific tissue resident CD8 T cells in human cervix mucosa
- (2021) Tao Peng et al. JCI Insight
- Thymic Function and T-Cell Receptor Repertoire Diversity: Implications for Patient Response to Checkpoint Blockade Immunotherapy
- (2021) Antonella Cardinale et al. Frontiers in Immunology
- 76 Spatial mapping of T cell receptors and transcriptomes in renal cell carcinoma following immune checkpoint inhibitor therapy
- (2021) Sophia Liu et al. Journal for ImmunoTherapy of Cancer
- T-Cell Receptor Repertoire Analysis with Computational Tools—An Immunologist’s Perspective
- (2021) Mahima Arunkumar et al. Cells
- Predominance of central memory T cells with high T-cell receptor repertoire diversity is associated with response to PD-1/PD-L1 inhibition in Merkel cell carcinoma
- (2020) Ivelina Spassova et al. CLINICAL CANCER RESEARCH
- T‐cell receptor diversity as a prognostic biomarker in melanoma patients
- (2020) Julie Charles et al. Pigment Cell & Melanoma Research
- TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer
- (2020) Timothy John Looney et al. Frontiers in Immunology
- Tumor mutational burden and immune infiltration as independent predictors of response to neoadjuvant immune checkpoint inhibition in early TNBC in GeparNuevo
- (2020) T. Karn et al. ANNALS OF ONCOLOGY
- Are immune-related adverse events associated with the efficacy of immune checkpoint inhibitors in patients with cancer? A systematic review and meta-analysis
- (2020) Xiaoxiang Zhou et al. BMC Medicine
- Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms
- (2020) Rong En Tay et al. CANCER GENE THERAPY
- T‐cell receptor affinity in the age of cancer immunotherapy
- (2020) Michele M. Hoffmann et al. MOLECULAR CARCINOGENESIS
- The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease
- (2020) Katherine Kedzierska et al. VIRAL IMMUNOLOGY
- Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues
- (2020) Andrew R. Marderstein et al. Nature Communications
- Immune-related adverse events of checkpoint inhibitors
- (2020) Manuel Ramos-Casals et al. Nature Reviews Disease Primers
- Significance of tumor mutation burden combined with immune infiltrates in the progression and prognosis of ovarian cancer
- (2020) Fangfang Bi et al. Cancer Cell International
- Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
- (2020) Andrew L. Ji et al. CELL
- Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy
- (2020) Adrienne M. Luoma et al. CELL
- A decade of immune-checkpoint inhibitors in cancer therapy
- (2020) Caroline Robert Nature Communications
- Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells
- (2020) Jan A. Rath et al. Science Advances
- Multi-omics analysis of tumor mutation burden combined with immune infiltrates in melanoma
- (2020) Feng Jiang et al. CLINICA CHIMICA ACTA
- T-cell repertoire analysis and metrics of diversity and clonality
- (2020) Johanna Chiffelle et al. CURRENT OPINION IN BIOTECHNOLOGY
- Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy
- (2020) Ying Jing et al. Nature Communications
- Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis
- (2020) Rebeca Sanz-Pamplona et al. PLOS MEDICINE
- Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade
- (2020) Weilei Hu et al. iScience
- Association of Tumor Microenvironment T-Cell Repertoire and Mutational Load With Clinical Outcome After Sequential Checkpoint Blockade in Melanoma
- (2019) Erik Yusko et al. Cancer Immunology Research
- Genesis of the αβ T-cell receptor
- (2019) Thomas Dupic et al. PLoS Computational Biology
- Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma
- (2019) Kurt A. Schalper et al. NATURE MEDICINE
- Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinoma
- (2019) Tao Jiang et al. Journal of Hematology & Oncology
- Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma
- (2019) Akiko Arakawa et al. Frontiers in Immunology
- The impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients
- (2019) Arjun Khunger et al. OncoImmunology
- Tools for fundamental analysis functions of TCR repertoires: a systematic comparison
- (2019) Yanfang Zhang et al. BRIEFINGS IN BIOINFORMATICS
- Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms
- (2019) Ibrahim Halil Sahin et al. BRITISH JOURNAL OF CANCER
- Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation
- (2019) Stéphane Buhler et al. LEUKEMIA
- TCR Repertoire Diversity of Peripheral PD-1+CD8+ T Cells Predicts Clinical Outcomes after Immunotherapy in Patients with Non–Small Cell Lung Cancer
- (2019) Jiefei Han et al. Cancer Immunology Research
- Diagnosis and Management of Immune Related Adverse Events (irAEs) in Cancer Immunotherapy
- (2019) Yi-He Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Cell Biology of T Cell Receptor Expression and Regulation
- (2018) Andrés Alcover et al. Annual Review of Immunology
- Hitting the Target: How T Cells Detect and Eliminate Tumors
- (2018) Anthony E. Zamora et al. JOURNAL OF IMMUNOLOGY
- Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
- (2018) Peter Savas et al. NATURE MEDICINE
- Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
- (2018) Patrick M. Forde et al. NEW ENGLAND JOURNAL OF MEDICINE
- Does patient age influence anti-cancer immunity?
- (2018) Graham Pawelec Seminars in Immunopathology
- T cell receptor repertoire profiling predicts the prognosis of HBV-associated hepatocellular carcinoma
- (2018) Kai-Rong Lin et al. Cancer Medicine
- NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives
- (2018) Remy Thomas et al. Frontiers in Immunology
- Biomarkers for Clinical Benefit of Immune Checkpoint Inhibitor Treatment—A Review From the Melanoma Perspective and Beyond
- (2018) Kristina Buder-Bakhaya et al. Frontiers in Immunology
- Targeting Macrophages in Cancer: From Bench to Bedside
- (2018) Ashleigh R. Poh et al. Frontiers in Oncology
- TCR repertoire profiling of tumors, adjacent normal tissues, and peripheral blood predicts survival in nasopharyngeal carcinoma
- (2018) Ya-bin Jin et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Spatially resolved transcriptomics enables dissection of genetic heterogeneity in stage III cutaneous malignant melanoma
- (2018) Kim Thrane et al. CANCER RESEARCH
- T cell receptor β-chain repertoire analysis of tumor-infiltrating lymphocytes in pancreatic cancer
- (2018) Can Cui et al. CANCER SCIENCE
- Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma
- (2018) Sabrina A. Hogan et al. Cancer Immunology Research
- TCR Repertoire as a Novel Indicator for Immune Monitoring and Prognosis Assessment of Patients With Cervical Cancer
- (2018) Jin-Huan Cui et al. Frontiers in Immunology
- High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors
- (2018) Saman Maleki Vareki Journal for ImmunoTherapy of Cancer
- Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
- (2017) Michael J Overman et al. LANCET ONCOLOGY
- T cell receptor sequencing of early-stage breast cancer tumors identifies altered clonal structure of the T cell repertoire
- (2017) John F. Beausang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
- (2017) Whijae Roh et al. Science Translational Medicine
- T cell receptor repertoire usage in cancer as a surrogate marker for immune responses
- (2017) David Schrama et al. Seminars in Immunopathology
- Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis
- (2017) Alexandra Snyder et al. PLOS MEDICINE
- A novel signature for stratifying the molecular heterogeneity of the tissue-infiltrating T-cell receptor repertoire reflects gastric cancer prognosis
- (2017) Manchao Kuang et al. Scientific Reports
- Variations in MHC Class II Antigen Processing and Presentation in Health and Disease
- (2016) Emil R. Unanue et al. Annual Review of Immunology
- Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire
- (2016) David Y. Oh et al. CANCER RESEARCH
- The T-cell Receptor Repertoire Influences the Tumor Microenvironment and Is Associated with Survival in Aggressive B-cell Lymphoma
- (2016) Colm Keane et al. CLINICAL CANCER RESEARCH
- MAGE-A is More Highly Expressed Than NY-ESO-1 in a Systematic Immunohistochemical Analysis of 3668 Cases
- (2016) Sid P. Kerkar et al. JOURNAL OF IMMUNOTHERAPY
- T cell receptor β-chain repertoire analysis reveals intratumour heterogeneity of tumour-infiltrating lymphocytes in oesophageal squamous cell carcinoma
- (2016) Zengchao Chen et al. JOURNAL OF PATHOLOGY
- Systematic Comparative Evaluation of Methods for Investigating the TCRβ Repertoire
- (2016) Xiao Liu et al. PLoS One
- Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities
- (2016) Sumit K. Subudhi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
- (2016) P. L. Stahl et al. SCIENCE
- Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor
- (2016) A. Pasetto et al. Cancer Immunology Research
- The Different T-cell Receptor Repertoires in Breast Cancer Tumors, Draining Lymph Nodes, and Adjacent Tissues
- (2016) Ting Wang et al. Cancer Immunology Research
- Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy
- (2016) D. B. Page et al. Cancer Immunology Research
- Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma
- (2016) Hiroyuki Inoue et al. OncoImmunology
- High-throughput T cell receptor sequencing reveals distinct repertoires between tumor and adjacent non-tumor tissues in HBV-associated HCC
- (2016) Yunqing Chen et al. OncoImmunology
- Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
- (2015) J. Naidoo et al. ANNALS OF ONCOLOGY
- T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules
- (2015) Jamie Rossjohn et al. Annual Review of Immunology
- CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
- (2015) S. L. Maude et al. BLOOD
- αβ T cell receptors as predictors of health and disease
- (2015) Meriem Attaf et al. Cellular & Molecular Immunology
- The MAGE protein family and cancer
- (2015) Jenny L Weon et al. CURRENT OPINION IN CELL BIOLOGY
- Landscape of Tumor Antigens in T Cell Immunotherapy
- (2015) S. Ilyas et al. JOURNAL OF IMMUNOLOGY
- Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors
- (2015) Xueli Bai et al. Scientific Reports
- Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer
- (2015) Qingzhu Jia et al. OncoImmunology
- The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells
- (2015) Madhav Sharma et al. Journal for ImmunoTherapy of Cancer
- Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma
- (2015) Michael A. Postow et al. Journal for ImmunoTherapy of Cancer
- A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
- (2014) P. F. Robbins et al. CLINICAL CANCER RESEARCH
- CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire
- (2014) L. Robert et al. CLINICAL CANCER RESEARCH
- Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
- (2014) Matthew M. Gubin et al. NATURE
- PD-1 blockade induces responses by inhibiting adaptive immune resistance
- (2014) Paul C. Tumeh et al. NATURE
- Towards error-free profiling of immune repertoires
- (2014) Mikhail Shugay et al. NATURE METHODS
- Improved Survival with T Cell Clonotype Stability After Anti-CTLA-4 Treatment in Cancer Patients
- (2014) E. Cha et al. Science Translational Medicine
- The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints
- (2014) Nicolas J. Llosa et al. Cancer Discovery
- Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
- (2014) Lidia Robert et al. OncoImmunology
- Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue
- (2013) Anna M. Sherwood et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma
- (2013) Phyu P. Aung et al. HUMAN PATHOLOGY
- High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer
- (2013) Ryan O Emerson et al. JOURNAL OF PATHOLOGY
- The Past, Present, and Future of Immune Repertoire Biology – The Rise of Next-Generation Repertoire Analysis
- (2013) Adrien Six et al. Frontiers in Immunology
- NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis
- (2012) Jin-Ping Lai et al. MODERN PATHOLOGY
- Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients
- (2012) Manuarii Manuel et al. OncoImmunology
- MAGE-A family: Attractive targets for cancer immunotherapy
- (2011) Meixiang Sang et al. VACCINE
- Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review
- (2010) Katsuhiko Nosho et al. JOURNAL OF PATHOLOGY
- Microsatellite instability in colorectal cancer—the stable evidence
- (2010) Eduardo Vilar et al. Nature Reviews Clinical Oncology
- Overlap and Effective Size of the Human CD8+ T Cell Receptor Repertoire
- (2010) H. S. Robins et al. Science Translational Medicine
- Comprehensive assessment of T-cell receptor -chain diversity in T cells
- (2009) H. S. Robins et al. BLOOD
- High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer
- (2009) Alain Bergeron et al. INTERNATIONAL JOURNAL OF CANCER
- Concurrent Trastuzumab and HER2/neu-Specific Vaccination in Patients With Metastatic Breast Cancer
- (2009) Mary L. Disis et al. JOURNAL OF CLINICAL ONCOLOGY
- CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
- (2008) J. Yuan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started