Chronic antigen in solid tumors drives a distinct program of T cell residence

An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

(2022) Abhinav Jaiswal et al.   CANCER CELL

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells

(2022) Carmen M. Anadon et al.   CANCER CELL

In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue

(2022) Zhi Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model

(2022) Stéphanie Corgnac et al.   Journal for ImmunoTherapy of Cancer

MYB orchestrates T cell exhaustion and response to checkpoint inhibition

(2022) Carlson Tsui et al.   NATURE

CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

(2022) Nataliya Prokhnevska et al.   IMMUNITY

Joint probabilistic modeling of single-cell multi-omic data with totalVI

(2021) Adam Gayoso et al.   NATURE METHODS

Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells

(2021) Ilkka Liikanen et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-resident memory T cells in tumor immunity and immunotherapy

(2021) Karolina Okła et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma

(2021) Yang Cheng et al.   IMMUNITY

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

(2021) Jason M. Schenkel et al.   IMMUNITY

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

(2021) Christiane S. Eberhardt et al.   NATURE

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma

(2021) Giacomo Oliveira et al.   NATURE

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

(2021) Susan N. Christo et al.   NATURE IMMUNOLOGY

Analyzing high-dimensional cytometry data using FlowSOM

(2021) Katrien Quintelier et al.   Nature Protocols

Tissue-specific differentiation of CD8+ resident memory T cells

(2021) Kun Yang et al.   TRENDS IN IMMUNOLOGY

A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response

(2021) Kelli A. Connolly et al.   Science Immunology

Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program

(2021) Farah Hasan et al.   JCI Insight

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

(2021) Mojdeh Shakiba et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The reactome pathway knowledgebase 2022

(2021) Marc Gillespie et al.   NUCLEIC ACIDS RESEARCH

Pan-cancer single-cell landscape of tumor-infiltrating T cells

(2021) Liangtao Zheng et al.   SCIENCE

PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection

(2020) Se Jin Im et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy

(2020) J. Justin Milner et al.   IMMUNITY

Tissue-resident memory-like T cells in tumor immunity: Clinical implications

(2020) Madhav V. Dhodapkar et al.   SEMINARS IN IMMUNOLOGY

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

(2019) Imran Siddiqui et al.   IMMUNITY

Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

(2019) Emily A. Thompson et al.   Cell Reports

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

(2019) Pamela C. Rosato et al.   Nature Communications

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Clonal replacement of tumor-specific T cells following PD-1 blockade

(2019) Kathryn E. Yost et al.   NATURE MEDICINE

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

(2019) Frank Koopmans et al.   NEURON

Location, location, location: Tissue resident memory T cells in mice and humans

(2019) Peter A. Szabo et al.   Science Immunology

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

(2019) Zeyu Chen et al.   IMMUNITY

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

(2019) Caroline S. Jansen et al.   NATURE

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

(2018) Lalit K. Beura et al.   IMMUNITY

Tissue-resident memory T cells at the center of immunity to solid tumors

(2018) Derk Amsen et al.   NATURE IMMUNOLOGY

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

(2018) Peter Savas et al.   NATURE MEDICINE

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

(2018) Simone L. Park et al.   NATURE

Deep generative modeling for single-cell transcriptomics

(2018) Romain Lopez et al.   NATURE METHODS

Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity

(2018) Aleksey Molodtsov et al.   Frontiers in Immunology

TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment

(2016) Marie Boutet et al.   CANCER RESEARCH

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data

(2015) Sofie Van Gassen et al.   CYTOMETRY PART A

Cutting Edge: Resident Memory CD8 T Cells Occupy Frontline Niches in Secondary Lymphoid Organs

(2014) J. M. Schenkel et al.   JOURNAL OF IMMUNOLOGY

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

CD103 or LFA-1 Engagement at the Immune Synapse between Cytotoxic T Cells and Tumor Cells Promotes Maturation and Regulates T-cell Effector Functions

(2012) K. Franciszkiewicz et al.   CANCER RESEARCH

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Minimal Engagement of CD103 on Cytotoxic T Lymphocytes with an E-Cadherin-Fc Molecule Triggers Lytic Granule Polarization via a Phospholipase Cγ–Dependent Pathway

(2011) Audrey Le Floc'h et al.   CANCER RESEARCH