‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses

Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection

(2021) Nina Hensel et al.   NATURE IMMUNOLOGY

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells

(2021) Anthony Kusnadi et al.   Science Immunology

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

(2021) Kristen E. Pauken et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

(2021) Chen Yao et al.   NATURE IMMUNOLOGY

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

(2021) Evan W. Weber et al.   SCIENCE

Recruiting T cells in cancer immunotherapy

(2021) Kathryn E. Yost et al.   SCIENCE

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

(2021) Mayura V. Wagle et al.   Nature Communications

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

(2021) Laura M. McLane et al.   Cell Reports

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

(2021) Sarah S. Gabriel et al.   IMMUNITY

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

(2021) Jason M. Schenkel et al.   IMMUNITY

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

(2021) Justina X. Caushi et al.   NATURE

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma

(2021) Giacomo Oliveira et al.   NATURE

Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans

(2021) Kathleen B. Yates et al.   NATURE IMMUNOLOGY

BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells

(2021) Hyungseok Seo et al.   NATURE IMMUNOLOGY

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

(2021) Mohamed S. Abdel-Hakeem et al.   NATURE IMMUNOLOGY

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

(2021) Yugang Guo et al.   NATURE IMMUNOLOGY

Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

(2021) Pierre Tonnerre et al.   NATURE IMMUNOLOGY

BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection

(2021) Yao Chen et al.   NATURE IMMUNOLOGY

PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure

(2021) Mélanie Charmoy et al.   Cell Reports

A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response

(2021) Kelli A. Connolly et al.   Science Immunology

Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

(2021) Yuanyuan Zhang et al.   CANCER CELL

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection

(2020) Kilian Schober et al.   NATURE IMMUNOLOGY

Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection

(2020) Suzanne P. M. Welten et al.   Nature Communications

Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy

(2020) Caitlin C. Zebley et al.   TRENDS IN IMMUNOLOGY

The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes

(2020) Floris Dammeijer et al.   CANCER CELL

T cell immunity to hepatitis C virus: lessons for a prophylactic HCV vaccine

(2020) Robert Thimme   JOURNAL OF HEPATOLOGY

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

(2020) Daniel T. Utzschneider et al.   NATURE IMMUNOLOGY

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection

(2020) Simon Grassmann et al.   NATURE IMMUNOLOGY

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

(2020) Giovanni Galletti et al.   NATURE IMMUNOLOGY

Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy

(2020) David M. Francis et al.   Science Translational Medicine

Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection

(2020) Ioana Sandu et al.   Nature Communications

MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

(2020) Vivek Verma et al.   NATURE IMMUNOLOGY

TCF-1 regulates HIV-specific CD8+ T cell expansion capacity

(2020) Rachel L. Rutishauser et al.   JCI Insight

Hepatitis D Virus-specific CD8+ T Cells Have a Memory-like Phenotype Associated With Viral Immune Escape in Patients With Chronic Hepatitis D Virus Infection

(2019) Helenie Kefalakes et al.   GASTROENTEROLOGY

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

(2019) Anita Schuch et al.   GUT

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

(2019) Imran Siddiqui et al.   IMMUNITY

Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection

(2019) Elham Beyranvand Nejad et al.   Journal for ImmunoTherapy of Cancer

A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma

(2019) Alexander C. Huang et al.   NATURE MEDICINE

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

NR4A transcription factors limit CAR T cell function in solid tumours

(2019) Joyce Chen et al.   NATURE

Fuel and brake of memory T cell inflation

(2019) Suzanne P. M. Welten et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The Transcriptome of Latent Human Cytomegalovirus

(2019) Michal Schwartz et al.   JOURNAL OF VIROLOGY

Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level

(2019) Hadi Karimzadeh et al.   GASTROENTEROLOGY

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

Early primed KLRG1- CMV-specific T cells determine the size of the inflationary T cell pool

(2019) Nicolas S. Baumann et al.   PLoS Pathogens

Remembering to remember: T cell memory maintenance and plasticity

(2019) Kyla D Omilusik et al.   CURRENT OPINION IN IMMUNOLOGY

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer

(2019) James Clarke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

(2019) Francesca Alfei et al.   NATURE

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

(2019) Chen Yao et al.   NATURE IMMUNOLOGY

Clonal replacement of tumor-specific T cells following PD-1 blockade

(2019) Kathryn E. Yost et al.   NATURE MEDICINE

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

(2019) Hyungseok Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade

(2019) Rohit R. Jadhav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

(2019) Kristiyan Kanev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

(2019) Zeyu Chen et al.   IMMUNITY

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

(2019) William H. Hudson et al.   IMMUNITY

CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

(2019) Ryan Zander et al.   IMMUNITY

c-Jun overexpression in CAR T cells induces exhaustion resistance

(2019) Rachel C. Lynn et al.   NATURE

Stem, Effector, and Hybrid States of Memory CD8+ T Cells

(2019) Enrico Lugli et al.   TRENDS IN IMMUNOLOGY

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

(2018) Masao Hashimoto et al.   Annual Review of Medicine

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Memory CD8 T cell inflation vs tissue-resident memory T cells: Same patrollers, same controllers?

(2018) Suzanne P. M. Welten et al.   IMMUNOLOGICAL REVIEWS

The (gradual) rise of memory inflation

(2018) Paul Klenerman   IMMUNOLOGICAL REVIEWS

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Tissue maintenance of CMV-specific inflationary memory T cells by IL-15

(2018) Nicolas S. Baumann et al.   PLoS Pathogens

High-dimensional single cell analysis identifies stem-like cytotoxic CD8+T cells infiltrating human tumors

(2018) Jolanda Brummelman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Lymph Nodes Maintain TCF-1hiMemory T Cells with High Functional Potential and Clonal Diversity throughout Life

(2018) Michelle Miron et al.   JOURNAL OF IMMUNOLOGY

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

(2018) Hanjie Li et al.   CELL

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

(2018) Laura M. Snell et al.   IMMUNITY

Defining Memory CD8 T Cell

(2018) Matthew D. Martin et al.   Frontiers in Immunology

Transcription Factor IRF4 Promotes CD8 + T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

(2017) Kevin Man et al.   IMMUNITY

Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

(2017) Lisa Borkner et al.   JOURNAL OF IMMUNOLOGY

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

(2017) Alexander C. Huang et al.   NATURE

Chromatin states define tumour-specific T cell dysfunction and reprogramming

(2017) Mary Philip et al.   NATURE

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

(2017) Dominik Wieland et al.   Nature Communications

Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies

(2016) M. Sabatino et al.   BLOOD

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

Dynamic Changes in Chromatin Accessibility Occur in CD8 + T Cells Responding to Viral Infection

(2016) James P. Scott-Browne et al.   IMMUNITY

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival

(2016) Daniel T. Utzschneider et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

(2016) Ran He et al.   NATURE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

(2016) Yew Ann Leong et al.   NATURE IMMUNOLOGY

IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection

(2016) Jean-Christophe Beltra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

(2016) Iryna Dekhtiarenko et al.   PLoS Pathogens

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells

(2015) Pamela M. Odorizzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Memory T Cells Specific for Murine Cytomegalovirus Re-Emerge after Multiple Challenges and Recapitulate Immunity in Various Adoptive Transfer Scenarios

(2015) Michael Quinn et al.   JOURNAL OF IMMUNOLOGY

Id3 Controls Cell Death of 2B4+Virus-Specific CD8+T Cells in Chronic Viral Infection

(2015) Alexandra J. Menner et al.   JOURNAL OF IMMUNOLOGY

Sleepless latency of human cytomegalovirus

(2015) Emma Poole et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Functional classification of memory CD8+ T cells by CX3CR1 expression

(2015) Jan P. Böttcher et al.   Nature Communications

Cytomegalovirus-Based Vaccine Expressing a Modified Tumor Antigen Induces Potent Tumor-Specific CD8 + T-cell Response and Protects Mice from Melanoma

(2015) Zhijuan Qiu et al.   Cancer Immunology Research

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

(2014) A. B. van der Waart et al.   BLOOD

NFATc1 Regulates PD-1 Expression upon T Cell Activation

(2014) K. J. Oestreich et al.   JOURNAL OF IMMUNOLOGY

Clonal Evolution of CD8+T Cell Responses against Latent Viruses: Relationship among Phenotype, Localization, and Function

(2014) Ester B. M. Remmerswaal et al.   JOURNAL OF VIROLOGY

Molecular regulation of effector and memory T cell differentiation

(2014) John T Chang et al.   NATURE IMMUNOLOGY

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

(2014) Marcus Buggert et al.   PLoS Pathogens

Decreased frequency of CD73+ CD8+ T cells of HIV-infected patients correlates with immune activation and T cell exhaustion

(2013) Ilona Tóth et al.   JOURNAL OF LEUKOCYTE BIOLOGY

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

(2013) Daniel T Utzschneider et al.   NATURE IMMUNOLOGY

Regulation of Human Cytomegalovirus Transcription in Latency: Beyond the Major Immediate-Early Promoter

(2013) Matthew Reeves et al.   Viruses-Basel

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

(2012) Helge Frebel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Cytomegalovirus-based Vaccine Expressing a Single Tumor-specific CD8+ T-cell Epitope Delays Tumor Growth in a Murine Model of Prostate Cancer

(2012) Elena N. Klyushnenkova et al.   JOURNAL OF IMMUNOTHERAPY

Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

(2012) J. M. Angelosanto et al.   JOURNAL OF VIROLOGY

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Memory T cell inflation: understanding cause and effect

(2012) Geraldine A. O’Hara et al.   TRENDS IN IMMUNOLOGY

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency

(2011) C. K. Seckert et al.   JOURNAL OF GENERAL VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

(2011) Charlly Kao et al.   NATURE IMMUNOLOGY

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

A Dominant Role for the Immunoproteasome in CD8+ T Cell Responses to Murine Cytomegalovirus

(2011) Sarah Hutchinson et al.   PLoS One

Sustained CD8+ T Cell Memory Inflation after Infection with a Single-Cycle Cytomegalovirus

(2011) Christopher M. Snyder et al.   PLoS Pathogens

Non-Hematopoietic Cells in Lymph Nodes Drive Memory CD8 T Cell Inflation during Murine Cytomegalovirus Infection

(2011) Nicole Torti et al.   PLoS Pathogens

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

(2010) G. Jeannet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

(2008) Christopher M. Snyder et al.   IMMUNITY