T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control

An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

(2022) Abhinav Jaiswal et al.   CANCER CELL

Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin

(2022) Madeline J. Churchill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue

(2022) Zhi Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-γ–dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

(2022) Laure Garnier et al.   Science Advances

Afferent Lymphatic Transport and Peripheral Tissue Immunity

(2021) Maria M. Steele et al.   JOURNAL OF IMMUNOLOGY

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

(2021) Evan W. Weber et al.   SCIENCE

MHC class II antigen presentation by lymphatic endothelial cells in tumors promotes intratumoral regulatory T cell suppressive functions

(2021) Anastasia O Gkountidi et al.   Cancer Immunology Research

Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas

(2021) Maria Stella Sasso et al.   Science Advances

Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

(2021) Megan L. Burger et al.   CELL

CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

(2021) Mauro Di Pilato et al.   CELL

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

(2021) Stefanie Lesch et al.   Nature Biomedical Engineering

A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response

(2021) Kelli A. Connolly et al.   Science Immunology

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

(2021) Mojdeh Shakiba et al.   JOURNAL OF EXPERIMENTAL MEDICINE

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

(2019) Imran Siddiqui et al.   IMMUNITY

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

(2019) Pamela C. Rosato et al.   Nature Communications

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

(2019) Ivy X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

(2019) Alexander N. Wein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

(2018) Bertram Bengsch et al.   IMMUNITY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy

(2018) Terry R. Medler et al.   CANCER CELL

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

(2018) Ryan S. Lane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

(2018) Wouter Scheper et al.   NATURE MEDICINE

UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model

(2017) Jake Wang et al.   Pigment Cell & Melanoma Research

In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors

(2017) Tommaso Torcellan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

(2017) Manuel Fankhauser et al.   Science Translational Medicine

Lymphatic Vessels Balance Viral Dissemination and Immune Activation following Cutaneous Viral Infection

(2017) Christopher P. Loo et al.   Cell Reports

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

(2017) Takahiro Tsujikawa et al.   Cell Reports

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

(2016) Andrea Schietinger et al.   IMMUNITY

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

(2016) Amanda W. Lund et al.   JOURNAL OF CLINICAL INVESTIGATION

Local antigen in nonlymphoid tissue promotes resident memory CD8+T cell formation during viral infection

(2016) Tahsin N. Khan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder

(2016) Arjun Krishnan et al.   NATURE NEUROSCIENCE

The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations

(2016) Katrina Meeth et al.   Pigment Cell & Melanoma Research

tcR: an R package for T cell receptor repertoire advanced data analysis

(2015) Vadim I. Nazarov et al.   BMC BIOINFORMATICS

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice

(2015) Yunching Chen et al.   HEPATOLOGY

Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation

(2015) Daniela Gómez et al.   JOURNAL OF IMMUNOLOGY

MiXCR: software for comprehensive adaptive immunity profiling

(2015) Dmitriy A Bolotin et al.   NATURE METHODS

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Cutting Edge: CD8+Recent Thymic Emigrants Exhibit Increased Responses to Low-Affinity Ligands and Improved Access to Peripheral Sites of Inflammation

(2014) Amy M. Berkley et al.   JOURNAL OF IMMUNOLOGY

Steady-State Antigen Scavenging, Cross-Presentation, and CD8+ T Cell Priming: A New Role for Lymphatic Endothelial Cells

(2014) S. Hirosue et al.   JOURNAL OF IMMUNOLOGY

CXCR4 Is Dispensable for T Cell Egress from Chronically Inflamed Skin via the Afferent Lymph

(2014) Skye A. Geherin et al.   PLoS One

VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis

(2013) A. K. Alitalo et al.   CANCER RESEARCH

CXCR4 promotes B cell egress from Peyer’s patches

(2013) Timothy H. Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner

(2011) B. Vigl et al.   BLOOD

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemoattractant Receptors and Lymphocyte Egress from Extralymphoid Tissue: Changing Requirements during the Course of Inflammation

(2010) M. N. Brown et al.   JOURNAL OF IMMUNOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Pertussis Toxin Signals through the TCR to Initiate Cross-Desensitization of the Chemokine Receptor CXCR4

(2009) O. D. Schneider et al.   JOURNAL OF IMMUNOLOGY

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Monitoring cellular movement in vivo with photoconvertible fluorescence protein "Kaede" transgenic mice

(2008) M. Tomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA