标题
Challenges and new technologies in adoptive cell therapy
作者
关键词
-
出版物
Journal of Hematology & Oncology
Volume 16, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2023-08-18
DOI
10.1186/s13045-023-01492-8
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Allogeneic BCMA-targeting CAR T cells in relapsed/refractory multiple myeloma: phase 1 UNIVERSAL trial interim results
- (2023) Sham Mailankody et al. NATURE MEDICINE
- Therapy with oncolytic viruses: progress and challenges
- (2023) Sophia Z. Shalhout et al. Nature Reviews Clinical Oncology
- Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
- (2023) Chengsong Yan et al. CANCER CELL
- Engineered exosome-mediated messenger RNA and single-chain variable fragment delivery for human chimeric antigen receptor T-cell engineering
- (2023) Ke Si et al. CYTOTHERAPY
- TET2 guards against unchecked BATF3-induced CAR T cell expansion
- (2023) Nayan Jain et al. NATURE
- Co-opting signalling molecules enables logic-gated control of CAR T cells
- (2023) Aidan M. Tousley et al. NATURE
- Long-term outcomes following CAR T cell therapy: what we know so far
- (2023) Kathryn M. Cappell et al. Nature Reviews Clinical Oncology
- Oncolytic adenovirus-mediated expression of CCL5 and IL12 facilitates CA9-targeting CAR-T therapy against renal cell carcinoma
- (2023) Lin Fang et al. PHARMACOLOGICAL RESEARCH
- Umbilical cord blood derived cellular therapy: advances in clinical development
- (2023) Jiasheng Wang et al. Frontiers in Oncology
- IPSC-derived CAR-NK cells for cancer immunotherapy
- (2023) Xiaotong Lin et al. BIOMEDICINE & PHARMACOTHERAPY
- Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
- (2022) J. Joseph Melenhorst et al. NATURE
- Off-the-shelf, Steroid Resistant, IL13Rα2-Specific CAR T Cells for Treatment of Glioblastoma
- (2022) Christine E Brown et al. NEURO-ONCOLOGY
- Allogeneic CD20‐targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B‐cell lymphoma models
- (2022) Kevin P Nishimoto et al. Clinical & Translational Immunology
- CAR-T Regulatory (CAR-Treg) Cells: Engineering and Applications
- (2022) Motahareh Arjomandnejad et al. Biomedicines
- Gamma delta (γδ) T cells in cancer immunotherapy; where it comes from, where it will go?
- (2022) Jiechu Deng et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression
- (2022) James R. Byrnes et al. MOLECULAR & CELLULAR PROTEOMICS
- Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors
- (2022) Yibo Yin et al. MOLECULAR THERAPY
- Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells
- (2022) Pritha Agarwalla et al. NATURE BIOTECHNOLOGY
- Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results
- (2022) Changsong Qi et al. NATURE MEDICINE
- Chimeric Antigen Receptor (CAR) Regulatory T-Cells in Solid Organ Transplantation
- (2022) Ilse Gille et al. Frontiers in Immunology
- When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer
- (2022) Mohamed S. Hasim et al. Science Advances
- A Novel Sushi-IL15-PD1 CAR-NK92 Cell Line With Enhanced and PD-L1 Targeted Cytotoxicity Against Pancreatic Cancer Cells
- (2022) Da-Lai Xu et al. Frontiers in Oncology
- Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing
- (2022) Sumin Jo et al. Nature Communications
- Decitabine-primed tandem CD19/CD22 CAR-T therapy in relapsed/refractory diffuse large B-cell lymphoma patients
- (2022) Changju Qu et al. Frontiers in Immunology
- Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy
- (2022) Wenyan Fu et al. Nature Biomedical Engineering
- Acid-sensing ion channel 1: potential therapeutic target for tumor
- (2022) Yinghong Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- CXCL11-armed oncolytic adenoviruses enhance CAR-T cell therapeutic efficacy and reprogram tumor microenvironment in glioblastoma
- (2022) Guoqing Wang et al. MOLECULAR THERAPY
- Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL
- (2022) Jiqin Zhang et al. NATURE
- Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus
- (2022) Andreas Mackensen et al. NATURE MEDICINE
- Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia
- (2022) Giorgio Ottaviano et al. Science Translational Medicine
- UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial
- (2022) Reuben Benjamin et al. Lancet Haematology
- Designing Cancer Immunotherapies That Engage T Cells and NK Cells
- (2022) Oleksandr Kyrysyuk et al. Annual Review of Immunology
- A Phase 1 Study of ADI-001: Anti-CD20 CAR-Engineered Allogeneic Gamma Delta1 (γδ) T Cells in Adults with B-Cell Malignancies
- (2022) Sattva S. Neelapu et al. BLOOD
- Innate Cell Engager AFM13 Combined with Preactivated and Expanded Cord Blood-Derived NK Cells for Patients with Double Refractory CD30+ Lymphoma
- (2022) Yago Nieto et al. BLOOD
- Phase 1 Study of CART-Ddbcma for the Treatment of Subjects with Relapsed and /or Refractory Multiple Myeloma
- (2022) Matthew Frigault et al. BLOOD
- The potential for Treg-enhancing therapies in transplantation
- (2022) Romy Steiner et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products
- (2022) Lipei Shao et al. Journal of Translational Medicine
- CAR-Macrophages and CAR-T Cells Synergistically Kill Tumor Cells In Vitro
- (2022) Maoxuan Liu et al. Cells
- Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- (2021) Stephen R Knight et al. LANCET
- Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
- (2021) Nicole E. Scharping et al. NATURE IMMUNOLOGY
- TALEN outperforms Cas9 in editing heterochromatin target sites
- (2021) Surbhi Jain et al. Nature Communications
- Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion
- (2021) David S.J. Allan et al. Molecular Therapy-Methods & Clinical Development
- Tet2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes
- (2021) Minjung Lee et al. CANCER RESEARCH
- CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia
- (2021) Yongxian Hu et al. CLINICAL CANCER RESEARCH
- A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity
- (2021) Huihui Zhang et al. Science Translational Medicine
- Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
- (2021) Mehmet Kemal Samur et al. Nature Communications
- Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model
- (2021) Yanan Wang et al. Frontiers in Immunology
- Development of non-viral ligand-dependent EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma
- (2021) Hiroshi Kubo et al. Molecular Therapy-Oncolytics
- Combination of CD19 and CD22 CAR‐T cell therapy in relapsed B‐cell acute lymphoblastic leukemia after allogeneic transplantation
- (2021) Shuangyou Liu et al. AMERICAN JOURNAL OF HEMATOLOGY
- An oncolytic virus expressing IL-15/IL-15Rα combined with off-the-shelf EGFR-CAR NK cells targets glioblastoma
- (2021) Rui Ma et al. CANCER RESEARCH
- SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models
- (2021) Axel Hyrenius-Wittsten et al. Science Translational Medicine
- Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models
- (2021) Dina Schneider et al. Science Translational Medicine
- SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
- (2021) Joseph H. Choe et al. Science Translational Medicine
- CAR-T cell therapy: current limitations and potential strategies
- (2021) Robert C. Sterner et al. Blood Cancer Journal
- Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
- (2021) Laura M. McLane et al. Cell Reports
- A nonviral, nonintegrating DNA nanovector platform for the safe, rapid, and persistent manufacture of recombinant T cells
- (2021) Matthias Bozza et al. Science Advances
- Nanocomplex‐Mediated In Vivo Programming to Chimeric Antigen Receptor‐M1 Macrophages for Cancer Therapy
- (2021) Mikyung Kang et al. ADVANCED MATERIALS
- The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function
- (2021) Lexus R. Johnson et al. CELL
- Current status and future directions of clinical applications using iPS cells—focus on Japan
- (2021) Hiraku Tsujimoto et al. FEBS Journal
- Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy
- (2021) Ana Luísa Correia et al. NATURE
- BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells
- (2021) Hyungseok Seo et al. NATURE IMMUNOLOGY
- Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
- (2021) Maik Luu et al. Nature Communications
- Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
- (2021) Huan-Chang Liang et al. Nature Communications
- NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness
- (2021) Mireia Bachiller et al. Journal for ImmunoTherapy of Cancer
- Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy
- (2021) Toshiaki Yoshikawa et al. BLOOD
- Allogeneic NKT Cells Expressing a CD19-Specific CAR in Patients with Relapsed or Refractory B-Cell Malignancies: An Interim Analysis
- (2021) Carlos A. Ramos et al. BLOOD
- A Phase 1 Safety and Efficacy Study of ADI-001 Anti-CD20 CAR-Engineered Allogeneic Gamma Delta (γδ) T Cells in Adults with B Cell Malignancies, in Monotherapy and Combination with IL-2
- (2021) Sattva S. Neelapu et al. BLOOD
- Safety and Efficacy of FT596, a First-in-Class, Multi-Antigen Targeted, Off-the-Shelf, iPSC-Derived CD19 CAR NK Cell Therapy in Relapsed/Refractory B-Cell Lymphoma
- (2021) Veronika Bachanova et al. BLOOD
- An NK-like CAR T cell transition in CAR T cell dysfunction
- (2021) Charly R. Good et al. CELL
- Improving CAR T-Cell Persistence
- (2021) Violena Pietrobon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer
- (2021) Huimin Zhang et al. Molecular Cancer
- Orthogonal Design of Experiments for Optimization of Lipid Nanoparticles for mRNA Engineering of CAR T Cells
- (2021) Margaret M. Billingsley et al. NANO LETTERS
- Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety
- (2021) Nhung Thi Nguyen et al. Nature Nanotechnology
- Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence
- (2021) Afroditi Katsarou et al. Science Translational Medicine
- An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma
- (2021) Paul-Joseph Aspuria et al. Science Translational Medicine
- A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia
- (2021) Qian Zhang et al. Science Translational Medicine
- Advances in Universal CAR-T Cell Therapy
- (2021) Haolong Lin et al. Frontiers in Immunology
- Current Perspectives on “Off-The-Shelf” Allogeneic NK and CAR-NK Cell Therapies
- (2021) Erica L. Heipertz et al. Frontiers in Immunology
- FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies
- (2020) Jode P Goodridge et al. BLOOD
- CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma
- (2020) Guangna Liu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Retroviral Insertional Mutagenesis in Humans: Evidence for Four Genetic Mechanisms Promoting Expansion of Cell Clones
- (2020) Frederic D. Bushman MOLECULAR THERAPY
- Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
- (2020) Margaret M. Billingsley et al. NANO LETTERS
- Interleukin-23 engineering improves CAR T cell function in solid tumors
- (2020) Xingcong Ma et al. NATURE BIOTECHNOLOGY
- The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity
- (2020) Dan Lu et al. NATURE IMMUNOLOGY
- Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
- (2020) Enli Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Engineering light-controllable CAR T cells for cancer immunotherapy
- (2020) Ziliang Huang et al. Science Advances
- Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment
- (2020) Aleksei Titov et al. Cancers
- Revving the CAR – Combination strategies to enhance CAR T cell effectiveness
- (2020) Rajat Bansal et al. BLOOD REVIEWS
- CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression
- (2020) Kristen Fousek et al. LEUKEMIA
- Cytokine IL-36γ improves CAR T-cell functionality and induces endogenous antitumor response
- (2020) Xinghuo Li et al. LEUKEMIA
- Directed evolution of adenine base editors with increased activity and therapeutic application
- (2020) Nicole M. Gaudelli et al. NATURE BIOTECHNOLOGY
- Human chimeric antigen receptor macrophages for cancer immunotherapy
- (2020) Michael Klichinsky et al. NATURE BIOTECHNOLOGY
- KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma
- (2020) Michael Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tuning the Antigen Density Requirement for CAR T-cell Activity
- (2020) Robbie G. Majzner et al. Cancer Discovery
- The architecture of EMC reveals a path for membrane protein insertion
- (2020) John P O'Donnell et al. eLife
- A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation
- (2020) Liman Niu et al. Science Advances
- Transposon-Based CAR T Cells in Acute Leukemias: Where are We Going?
- (2020) Chiara F Magnani et al. Cells
- piggyBac-Based Non-Viral In Vivo Gene Delivery Useful for Production of Genetically Modified Animals and Organs
- (2020) Masahiro Sato et al. Pharmaceutics
- Metabolic signaling in T cells
- (2020) Justin A. Shyer et al. CELL RESEARCH
- Anti-EGFR chimeric antigen receptor-modified T cells in metastatic pancreatic carcinoma: A phase I clinical trial
- (2020) Yang Liu et al. CYTOTHERAPY
- Cost of decentralized CAR T‐cell production in an academic nonprofit setting
- (2020) Tao Ran et al. INTERNATIONAL JOURNAL OF CANCER
- Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
- (2020) Rashi Singhal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Recent advances in CAR-T cell engineering
- (2020) Ruihao Huang et al. Journal of Hematology & Oncology
- Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery
- (2020) Cesar Sommer et al. MOLECULAR THERAPY
- IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors
- (2020) Lauren Giuffrida et al. MOLECULAR THERAPY
- Macrophages enter CAR immunotherapy
- (2020) Madhura Mukhopadhyay NATURE METHODS
- Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor
- (2020) Ying Gong et al. Molecular Therapy-Methods & Clinical Development
- Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer
- (2020) Yan Xu et al. Cellular & Molecular Immunology
- Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis
- (2020) Andras Heczey et al. NATURE MEDICINE
- Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas
- (2020) Qing Deng et al. NATURE MEDICINE
- Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial
- (2020) Nirav N. Shah et al. NATURE MEDICINE
- Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors
- (2020) Anthony K. Park et al. Science Translational Medicine
- Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells
- (2020) Christoph Mark et al. Nature Communications
- Chimeric antigen receptor‐modified macrophages trigger systemic anti‐tumour immunity
- (2020) Zhiyuan Niu et al. JOURNAL OF PATHOLOGY
- Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies
- (2020) Reuben Benjamin et al. LANCET
- Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
- (2020) Sri Krishna et al. SCIENCE
- The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth
- (2020) Pengxiang Yang et al. CELLULAR IMMUNOLOGY
- Eradication of neuroblastoma by T cells redirected with an optimized GD2-specific chimeric antigen receptor and interleukin-15
- (2019) Yuhui Chen et al. CLINICAL CANCER RESEARCH
- IL-15-mediated reduction of mTORC1 activity preserves the stem cell memory phenotype of CAR-T cells and confers superior antitumor activity
- (2019) Darya Alizadeh et al. Cancer Immunology Research
- NR4A transcription factors limit CAR T cell function in solid tumours
- (2019) Joyce Chen et al. NATURE
- Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients
- (2019) Lin Xiao et al. MOLECULAR THERAPY
- Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313
- (2019) Ramesh K. Ramanathan et al. JOURNAL OF CLINICAL ONCOLOGY
- T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy
- (2019) Tori N. Yamamoto et al. JOURNAL OF CLINICAL INVESTIGATION
- Granulocyte-macrophage colony-stimulating factor inactivation in CAR T-Cells prevents monocyte-dependent release of key cytokine release syndrome mediators
- (2019) Mohit Sachdeva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting
- (2019) Shivani Srivastava et al. CANCER CELL
- CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response
- (2019) Nicholas F. Kuhn et al. CANCER CELL
- CAR-T–cell neurotoxicity: hope is on the horizon
- (2019) Omar Ahmed BLOOD
- MODULATION OF ANTI-TUMOUR ACTIVITY OF EX VIVO EXPANDED NK AND GD2CAR-NK CELLS AGAINST NEUROBLASTOMA
- (2019) S. Shen et al. CYTOTHERAPY
- The metabolic spectrum of memory T cells
- (2019) David O'Sullivan IMMUNOLOGY AND CELL BIOLOGY
- B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma
- (2019) Adam D. Cohen et al. JOURNAL OF CLINICAL INVESTIGATION
- Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma
- (2019) Cesar Sommer et al. MOLECULAR THERAPY
- Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies
- (2019) Lorraine Springuel et al. BIODRUGS
- Modulation of chimeric antigen receptor surface expression by a small molecule switch
- (2019) Alexandre Juillerat et al. BMC BIOTECHNOLOGY
- Production of CAR T-cells by GMP-grade lentiviral vectors: Latest advances and future prospects
- (2019) Mansour Poorebrahim et al. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
- CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
- (2019) Bryan D. Choi et al. NATURE BIOTECHNOLOGY
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
- (2019) Hyungseok Seo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells
- (2019) Katrin Mestermann et al. Science Translational Medicine
- An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment
- (2019) Yi Wang et al. Frontiers in Immunology
- γ-secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma
- (2019) Margot J. Pont et al. BLOOD
- Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix
- (2019) Wenlong Zhang et al. BRITISH JOURNAL OF CANCER
- Engineering γδT cells limits tonic signaling associated with chimeric antigen receptors
- (2019) Jonathan Fisher et al. Science Signaling
- Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model
- (2019) Kim Anthony-Gonda et al. Science Translational Medicine
- PD-1 silencing impairs the anti-tumor function of chimeric antigen receptor modified T cells by inhibiting proliferation activity
- (2019) Jianshu Wei et al. Journal for ImmunoTherapy of Cancer
- Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference
- (2019) Sara Charmsaz et al. Cancers
- Reactive Oxygen Species in the Tumor Microenvironment: An Overview
- (2019) Frank Weinberg et al. Cancers
- Combination of NKTR-255, a Polymer Conjugated Human IL-15, with CD19 CAR T Cell Immunotherapy in a Preclinical Lymphoma Model
- (2019) Cassie Chou et al. BLOOD
- Enhancing the Effect of CLL-1 CAR T Cells with Interleukin-15 for Treatment of Acute Myeloid Leukemia
- (2019) Pinar Ataca Atilla et al. BLOOD
- Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors
- (2019) Rachel Grosser et al. CANCER CELL
- Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer
- (2019) Yanni Zhu et al. Cell Stem Cell
- TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
- (2019) Zeyu Chen et al. IMMUNITY
- CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
- (2019) Wenyan Fu et al. Nature Communications
- Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors
- (2019) Beau R. Webber et al. Nature Communications
- An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics
- (2019) Molly E. Allen et al. ACS Synthetic Biology
- Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
- (2019) Beatris Mastelic-Gavillet et al. Journal for ImmunoTherapy of Cancer
- Doxycycline Inducible Chimeric Antigen Receptor T Cells Targeting CD147 for Hepatocellular Carcinoma Therapy
- (2019) Ren-Yu Zhang et al. Frontiers in Cell and Developmental Biology
- Engineering strategies to overcome the current roadblocks in CAR T cell therapy
- (2019) Sarwish Rafiq et al. Nature Reviews Clinical Oncology
- Adult peripheral blood and umbilical cord blood NK cells are good sources for effective CAR therapy against CD19 positive leukemic cells
- (2019) L. Herrera et al. Scientific Reports
- CXCR1 Expression to Improve Anti-Cancer Efficacy of Intravenously Injected CAR-NK Cells in Mice with Peritoneal Xenografts
- (2019) Yu Yang Ng et al. Molecular Therapy-Oncolytics
- Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
- (2018) Jang Hwan Cho et al. CELL
- Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity
- (2018) Ye Li et al. Cell Stem Cell
- A guide to manufacturing CAR T cell therapies
- (2018) Philipp Vormittag et al. CURRENT OPINION IN BIOTECHNOLOGY
- Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward
- (2018) Jian Li et al. Journal of Hematology & Oncology
- Clinical use of lentiviral vectors
- (2018) Michael C. Milone et al. LEUKEMIA
- Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation
- (2018) Anna Capsomidis et al. MOLECULAR THERAPY
- Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
- (2018) Christopher C. Kloss et al. MOLECULAR THERAPY
- Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
- (2018) Margherita Norelli et al. NATURE MEDICINE
- Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
- (2018) Joseph A. Fraietta et al. NATURE MEDICINE
- A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects
- (2018) Yuki Kagoya et al. NATURE MEDICINE
- FDA Approval Summary: Tocilizumab for Treatment of Chimeric Antigen Receptor T Cell‐Induced Severe or Life‐Threatening Cytokine Release Syndrome
- (2018) Robert Q. Le et al. ONCOLOGIST
- Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design
- (2018) Esther Drent et al. PLoS One
- Clinical and Biologic Correlates of Neurotoxicity Associated with CAR T Cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia (B-ALL)
- (2018) Bianca D. Santomasso et al. Cancer Discovery
- IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner
- (2018) Romy Loschinski et al. Oncotarget
- Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System
- (2018) Mauro P. Avanzi et al. Cell Reports
- Chimeric antigen receptors that trigger phagocytosis
- (2018) Meghan A Morrissey et al. eLife
- Functional Plasticity of Gamma Delta T Cells and Breast Tumor Targets in Hypoxia
- (2018) Gabrielle M. Siegers et al. Frontiers in Immunology
- γδ T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion
- (2018) Elena Lo Presti et al. Frontiers in Immunology
- Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma
- (2018) Concetta Quintarelli et al. OncoImmunology
- pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma
- (2018) Olga Kuchuk et al. OncoImmunology
- Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma
- (2018) Masao Nakagawa et al. CANCER CELL
- The Generation of CAR-Transfected Natural Killer T Cells for the Immunotherapy of Melanoma
- (2018) Bianca Simon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- IL-21 Selectively Protects CD62L+NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy
- (2018) Ho Ngai et al. JOURNAL OF IMMUNOLOGY
- Genome-wide analyses and functional profiling of human NK cell lines
- (2018) Justin T. Gunesch et al. MOLECULAR IMMUNOLOGY
- In vivo fate and activity of second versus third-generation D19-specific CAR-T cells in B-cell non-Hodgkin lymphomas
- (2018) Carlos A. Ramos et al. MOLECULAR THERAPY
- Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
- (2018) Joseph A. Fraietta et al. NATURE
- Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo
- (2018) Sarwish Rafiq et al. NATURE BIOTECHNOLOGY
- Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy
- (2018) Charlotte M. Mousset et al. OncoImmunology
- Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting
- (2018) Antonia Rotolo et al. CANCER CELL
- CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions
- (2018) Wanghong Hu et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Use of a Single CAR T Cell and Several Bispecific Adapters Facilitates Eradication of Multiple Antigenically Different Solid Tumors
- (2018) Yong Gu Lee et al. CANCER RESEARCH
- Development of Inducible CD19-CAR T Cells with a Tet-On System for Controlled Activity and Enhanced Clinical Safety
- (2018) Xingjian Gu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Universal CARs, universal T cells, and universal CAR T cells
- (2018) Juanjuan Zhao et al. Journal of Hematology & Oncology
- Macrophages hold the key to cancer’s inner sanctum
- (2018) Gerald L. Wolf MEDICAL HYPOTHESES
- High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells
- (2018) Jing Li et al. Frontiers in Immunology
- Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma
- (2017) Kai-chao Feng et al. Journal of Hematology & Oncology
- Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains
- (2017) Daniel T. Harris et al. JOURNAL OF IMMUNOLOGY
- Fully human CD19-specific chimeric antigen receptors for T-cell therapy
- (2017) D Sommermeyer et al. LEUKEMIA
- Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity
- (2017) E Liu et al. LEUKEMIA
- An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma
- (2017) A Lollies et al. LEUKEMIA
- Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells
- (2017) Daniel T. MacLeod et al. MOLECULAR THERAPY
- Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor
- (2017) Jonathan Fisher et al. MOLECULAR THERAPY
- CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma
- (2017) Andras Heczey et al. MOLECULAR THERAPY
- Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40
- (2017) Aaron E. Foster et al. MOLECULAR THERAPY
- Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer
- (2017) Somala Mohammed et al. MOLECULAR THERAPY
- Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
- (2017) Justin Eyquem et al. NATURE
- Unexpected mutations after CRISPR–Cas9 editing in vivo
- (2017) Kellie A Schaefer et al. NATURE METHODS
- In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers
- (2017) Tyrel T. Smith et al. Nature Nanotechnology
- Tumour-associated macrophages as treatment targets in oncology
- (2017) Alberto Mantovani et al. Nature Reviews Clinical Oncology
- Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia
- (2017) Hagop Kantarjian et al. NEW ENGLAND JOURNAL OF MEDICINE
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- (2017) Donald M. O’Rourke et al. Science Translational Medicine
- Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
- (2017) Waseem Qasim et al. Science Translational Medicine
- Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells
- (2017) Juliane Gust et al. Cancer Discovery
- CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
- (2017) Levi J. Rupp et al. Scientific Reports
- An oxygen sensitive self-decision making engineered CAR T-cell
- (2017) Alexandre Juillerat et al. Scientific Reports
- Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment
- (2017) Oladapo O. Yeku et al. Scientific Reports
- CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors
- (2017) Markus Chmielewski et al. Cell Reports
- Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18
- (2017) Biliang Hu et al. Cell Reports
- Bioengineering Solutions for Manufacturing Challenges in CAR T Cells
- (2017) Nicole J. Piscopo et al. Biotechnology Journal
- Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer
- (2017) Julia Tchou et al. Cancer Immunology Research
- Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants
- (2017) Giedre Krenciute et al. Cancer Immunology Research
- Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy
- (2017) Anne-Sophie Gautron et al. Molecular Therapy-Nucleic Acids
- CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
- (2017) Yongping Zhang et al. Frontiers of Medicine
- mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting
- (2017) Jason J. Lohmueller et al. OncoImmunology
- Diverse macrophages polarization in tumor microenvironment
- (2016) Inmoo Rhee ARCHIVES OF PHARMACAL RESEARCH
- Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies
- (2016) M. Sabatino et al. BLOOD
- Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy
- (2016) Hamid Reza Mirzaei et al. CANCER LETTERS
- A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
- (2016) Xiaojun Liu et al. CANCER RESEARCH
- Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells
- (2016) Michael Boice et al. CELL
- Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits
- (2016) Kole T. Roybal et al. CELL
- Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors
- (2016) Leonardo Morsut et al. CELL
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors
- (2016) Kole T. Roybal et al. CELL
- CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells
- (2016) Xiaojuan Liu et al. CELL RESEARCH
- Driving gene-engineered T cell immunotherapy of cancer
- (2016) Laura A Johnson et al. CELL RESEARCH
- Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
- (2016) Jiangtao Ren et al. CLINICAL CANCER RESEARCH
- Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
- (2016) Omkar U. Kawalekar et al. IMMUNITY
- Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
- (2016) Leonid Cherkassky et al. JOURNAL OF CLINICAL INVESTIGATION
- CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo
- (2016) Gengwen Tian et al. JOURNAL OF CLINICAL INVESTIGATION
- Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma
- (2016) Stephanie L. Goff et al. JOURNAL OF CLINICAL ONCOLOGY
- GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade
- (2016) Tessa Gargett et al. MOLECULAR THERAPY
- Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System
- (2016) Drew C Deniger et al. MOLECULAR THERAPY
- Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
- (2016) Wei Yang et al. NATURE
- Ionic immune suppression within the tumour microenvironment limits T cell effector function
- (2016) Robert Eil et al. NATURE
- Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system
- (2016) Michael J Workman et al. NATURE MEDICINE
- Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
- (2016) Christine E. Brown et al. NEW ENGLAND JOURNAL OF MEDICINE
- Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair
- (2016) Xiangjun He et al. NUCLEIC ACIDS RESEARCH
- Versatile strategy for controlling the specificity and activity of engineered T cells
- (2016) Jennifer S. Y. Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells
- (2016) Lenka V. Hurton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells
- (2016) Fengtao You et al. Science China-Life Sciences
- Efficient Regeneration of Human Vα24+Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo
- (2016) Daisuke Yamada et al. STEM CELLS
- Viral Vectors: The Road to Reducing Genotoxicity
- (2016) Rhiannon M. David et al. TOXICOLOGICAL SCIENCES
- Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice
- (2016) X Liu et al. Blood Cancer Journal
- Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia
- (2016) D. T. Teachey et al. Cancer Discovery
- Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model
- (2016) Eloah Rabello Suarez et al. Oncotarget
- Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells
- (2016) Godehard Scholz et al. EBioMedicine
- Multiplexed gene transfer to a human T-cell line by combining Sleeping Beauty transposon system with methotrexate selection
- (2015) Nataly Kacherovsky et al. BIOTECHNOLOGY AND BIOENGINEERING
- Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation
- (2015) X. Zhou et al. BLOOD
- Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T
- (2015) Rachel A. Burga et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
- (2015) Laurent Poirot et al. CANCER RESEARCH
- Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice
- (2015) X. Liu et al. CANCER RESEARCH
- Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6
- (2015) L. M. Draper et al. CLINICAL CANCER RESEARCH
- Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma
- (2015) L. Zhang et al. CLINICAL CANCER RESEARCH
- Blockade of Programmed Death 1 Augments the Ability of Human T Cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer
- (2015) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases
- (2015) S. C. Katz et al. CLINICAL CANCER RESEARCH
- Genetically modified T cells in cancer therapy: opportunities and challenges
- (2015) M. Sharpe et al. Disease Models & Mechanisms
- The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
- (2015) Gustavo J. Martinez et al. IMMUNITY
- Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus–Targeted Tumor-Infiltrating T Cells
- (2015) Sanja Stevanović et al. JOURNAL OF CLINICAL ONCOLOGY
- T cell metabolism drives immunity
- (2015) Michael D. Buck et al. JOURNAL OF EXPERIMENTAL MEDICINE
- DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy
- (2015) Katrin Töpfer et al. JOURNAL OF IMMUNOLOGY
- Redirection of Genetically Engineered CAR-T Cells Using Bifunctional Small Molecules
- (2015) Min Soo Kim et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma
- (2015) Congcong Zhang et al. JNCI-Journal of the National Cancer Institute
- A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer
- (2015) Mythili Koneru et al. Journal of Translational Medicine
- Enhancing Antitumor Efficacy of Chimeric Antigen Receptor T Cells Through Constitutive CD40L Expression
- (2015) Kevin J Curran et al. MOLECULAR THERAPY
- Chimeric Antigen Receptors With Mutated IgG4 Fc Spacer Avoid Fc Receptor Binding and Improve T Cell Persistence and Antitumor Efficacy
- (2015) Mahesh Jonnalagadda et al. MOLECULAR THERAPY
- Therapeutic genome editing: prospects and challenges
- (2015) David Benjamin Turitz Cox et al. NATURE MEDICINE
- Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
- (2015) Ignazio Caruana et al. NATURE MEDICINE
- NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma
- (2015) Aaron P Rapoport et al. NATURE MEDICINE
- The prognostic landscape of genes and infiltrating immune cells across human cancers
- (2015) Andrew J Gentles et al. NATURE MEDICINE
- Adoptive cell transfer as personalized immunotherapy for human cancer
- (2015) S. A. Rosenberg et al. SCIENCE
- Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma
- (2015) Laura A. Johnson et al. Science Translational Medicine
- piggyBac-ing models and new therapeutic strategies
- (2015) Lauren E. Woodard et al. TRENDS IN BIOTECHNOLOGY
- Overcoming T cell exhaustion in infection and cancer
- (2015) Kristen E. Pauken et al. TRENDS IN IMMUNOLOGY
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
- (2015) Robert Haas et al. PLOS BIOLOGY
- ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma
- (2015) Congcong Zhang et al. JNCI-Journal of the National Cancer Institute
- Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors
- (2015) Q. J. Wang et al. Cancer Immunology Research
- IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumorsin vivo
- (2015) Mythili Koneru et al. OncoImmunology
- Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition
- (2015) Maud Condomines et al. PLoS One
- CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells
- (2015) Jianfeng Han et al. Scientific Reports
- A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
- (2014) B. Philip et al. BLOOD
- Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
- (2014) Y. Xu et al. BLOOD
- Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy
- (2014) A. Heczey et al. BLOOD
- Sleeping Beautytransposon system for genetic etiological research and gene therapy of cancers
- (2014) Xiaomei Hou et al. CANCER BIOLOGY & THERAPY
- A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptor
- (2014) Christian Krug et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors
- (2014) N. Nishio et al. CANCER RESEARCH
- CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models
- (2014) Y. Zhu et al. CANCER RESEARCH
- Human Viral Oncogenesis: A Cancer Hallmarks Analysis
- (2014) Enrique A. Mesri et al. Cell Host & Microbe
- A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
- (2014) P. F. Robbins et al. CLINICAL CANCER RESEARCH
- Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors
- (2014) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Transforming Growth Factor β-Mediated Suppression of Antitumor T Cells Requires FoxP1 Transcription Factor Expression
- (2014) Tom L. Stephen et al. IMMUNITY
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
- (2014) David O’Sullivan et al. IMMUNITY
- T Cell Receptor Transfer to T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo
- (2014) L. T. van der Veken et al. JOURNAL OF IMMUNOLOGY
- Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor
- (2014) Ann M Leen et al. MOLECULAR THERAPY
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
- (2014) M. L. Davila et al. Science Translational Medicine
- Cancer Immunotherapy Using γδT Cells: Dealing with Diversity
- (2014) Wouter Scheper et al. Frontiers in Immunology
- Extracellular Adenosine-Mediated Modulation of Regulatory T Cells
- (2014) Akio Ohta et al. Frontiers in Immunology
- Metabolic Regulation of T Lymphocytes
- (2013) Nancie J. MacIver et al. Annual Review of Immunology
- Toward eliminating HLA class I expression to generate universal cells from allogeneic donors
- (2013) H. Torikai et al. BLOOD
- T Lymphocytes Expressing a CD16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing
- (2013) K. Kudo et al. CANCER RESEARCH
- Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition
- (2013) S. K. Perna et al. CLINICAL CANCER RESEARCH
- Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells
- (2013) L. B. John et al. CLINICAL CANCER RESEARCH
- M1 and M2 Macrophages: Oracles of Health and Disease
- (2013) Charles Mills CRITICAL REVIEWS IN IMMUNOLOGY
- 4-1BB signal stimulates the activation, expansion, and effector functions of γδ T cells in mice and humans
- (2013) Seung J. Lee et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
- (2013) S. W. Cho et al. GENOME RESEARCH
- A new approach to gene therapy usingSleeping Beautyto genetically modify clinical-grade T cells to target CD19
- (2013) Harjeet Singh et al. IMMUNOLOGICAL REVIEWS
- Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible
- (2013) Akio Ohta et al. INTERNATIONAL IMMUNOLOGY
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor
- (2013) Drew C Deniger et al. MOLECULAR THERAPY
- Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity
- (2013) Cor HJ Lamers et al. MOLECULAR THERAPY
- Reassessing target antigens for adoptive T-cell therapy
- (2013) Christian S Hinrichs et al. NATURE BIOTECHNOLOGY
- CSF-1R inhibition alters macrophage polarization and blocks glioma progression
- (2013) Stephanie M Pyonteck et al. NATURE MEDICINE
- Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors
- (2013) James N. Kochenderfer et al. Nature Reviews Clinical Oncology
- PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses
- (2013) V. D. Fedorov et al. Science Translational Medicine
- Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
- (2013) G. L. Beatty et al. Cancer Immunology Research
- Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo
- (2013) E. Lanitis et al. Cancer Immunology Research
- TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy
- (2013) Zakaria Grada et al. Molecular Therapy-Nucleic Acids
- Lentiviral vectors: basic to translational
- (2012) Toshie Sakuma et al. BIOCHEMICAL JOURNAL
- Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
- (2012) H. J. Pegram et al. BLOOD
- IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
- (2012) N. Cieri et al. BLOOD
- A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR
- (2012) H. Torikai et al. BLOOD
- Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI
- (2012) Gabrielle M. Siegers et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor
- (2012) K. Urbanska et al. CANCER RESEARCH
- Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
- (2012) A. Calcinotto et al. CANCER RESEARCH
- Local Delivery of lnterleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice
- (2012) D. Chinnasamy et al. CLINICAL CANCER RESEARCH
- Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies
- (2012) K. Tamada et al. CLINICAL CANCER RESEARCH
- Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation
- (2012) Rajesh R. Rao et al. IMMUNITY
- De NovoDNA Methylation Is Required to Restrict T Helper Lineage Plasticity
- (2012) Rajan M. Thomas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling
- (2012) Scott Wilkie et al. JOURNAL OF CLINICAL IMMUNOLOGY
- IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity
- (2012) Daofeng Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Macrophage plasticity and polarization: in vivo veritas
- (2012) Antonio Sica et al. JOURNAL OF CLINICAL INVESTIGATION
- Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
- (2012) Hélène Salmon et al. JOURNAL OF CLINICAL INVESTIGATION
- B7-CD28 Costimulatory Signals Control the Survival and Proliferation of Murine and Human T Cells via IL-2 Production
- (2012) J. C. Ribot et al. JOURNAL OF IMMUNOLOGY
- Evaluation of Long-term Transgene Expression in piggyBac-Modified Human T Lymphocytes
- (2012) Yozo Nakazawa et al. JOURNAL OF IMMUNOTHERAPY
- Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
- (2012) Christopher C Kloss et al. NATURE BIOTECHNOLOGY
- Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells
- (2012) J. Scholler et al. Science Translational Medicine
- Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety
- (2011) T. Ochi et al. BLOOD
- A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
- (2011) X. Wang et al. BLOOD
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression
- (2011) M. Chmielewski et al. CANCER RESEARCH
- Searching for “signal 2”: costimulation requirements of γδ T cells
- (2011) Julie C. Ribot et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
- (2011) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
- (2011) S. A. Rosenberg et al. CLINICAL CANCER RESEARCH
- The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor
- (2011) Z Jin et al. GENE THERAPY
- Nonviral Gene Delivery with the Sleeping Beauty Transposon System
- (2011) Zoltán Ivics et al. HUMAN GENE THERAPY
- Hyperactive piggyBac Gene Transfer in Human Cells and In Vivo
- (2011) Joseph E. Doherty et al. HUMAN GENE THERAPY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
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- (2011) Antonio Di Stasi et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2010) Zsuzsanna Izsvák et al. BIOESSAYS
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- (2010) J. Marvel et al. BLOOD
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- (2010) Ana deBarros et al. EUROPEAN JOURNAL OF IMMUNOLOGY
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- (2010) Elisa Kieback et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and unintended initiation of an innate immune response
- (2010) A Hombach et al. GENE THERAPY
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- (2010) Scott Wilkie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Geertrui Tavernier et al. JOURNAL OF CONTROLLED RELEASE
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- (2010) V Hoyos et al. LEUKEMIA
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- (2010) Richard A Morgan et al. MOLECULAR THERAPY
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- (2010) Maria R Parkhurst et al. MOLECULAR THERAPY
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- (2010) Gavin M Bendle et al. NATURE MEDICINE
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- (2010) Michael Quigley et al. NATURE MEDICINE
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- (2010) Yannick Doyon et al. NATURE METHODS
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- (2010) M. M. van Loenen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
- (2009) L. A. Johnson et al. BLOOD
- CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells
- (2009) T. Baessler et al. BLOOD
- Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection
- (2009) R. E. Throm et al. BLOOD
- T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
- (2009) A. Di Stasi et al. BLOOD
- Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy
- (2009) H. Fujisaki et al. CANCER RESEARCH
- Combination therapy ofin vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma
- (2009) Naoki Kunii et al. CANCER SCIENCE
- Adoptive cell therapy for the treatment of patients with metastatic melanoma
- (2009) Steven A Rosenberg et al. CURRENT OPINION IN IMMUNOLOGY
- Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy
- (2009) M. Griffioen et al. HAEMATOLOGICA
- Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses
- (2009) Axel Kallies et al. IMMUNITY
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- (2009) Haina Shin et al. IMMUNITY
- NKT cells in mucosal immunity
- (2009) S Middendorp et al. Mucosal Immunology
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- Regulation and Functions of Blimp-1 in T and B Lymphocytes
- (2008) Gislâine Martins et al. Annual Review of Immunology
- Resistance of mature T cells to oncogene transformation
- (2008) S. Newrzela et al. BLOOD
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- (2008) Vincent T. DeVita et al. CANCER RESEARCH
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- (2008) Angela Ciuffi CURRENT GENE THERAPY
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- (2008) Candace M. Cham et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
- (2008) Steven J. Howe et al. JOURNAL OF CLINICAL INVESTIGATION
- Harnessing the tumour-derived cytokine, CSF-1, to co-stimulate T-cell growth and activation
- (2007) Agnes Shuk Yee Lo et al. MOLECULAR IMMUNOLOGY
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