Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
出版年份 2019 全文链接
标题
Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
作者
关键词
-
出版物
Journal for ImmunoTherapy of Cancer
Volume 7, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-10-14
DOI
10.1186/s40425-019-0719-5
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Development of immune checkpoint therapy for cancer
- (2019) Jill M. Fritz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
- (2019) Selena Vigano et al. Frontiers in Immunology
- Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models
- (2018) Robert D. Leone et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A2AAdenosine Receptor Gene Deletion or Synthetic A2AAntagonist Liberate Tumor-Reactive CD8+T Cells from Tumor-Induced Immunosuppression
- (2018) Jorgen Kjaergaard et al. JOURNAL OF IMMUNOLOGY
- Sensitive and frequent identification of high avidity neo-epitope specific CD8+ T cells in immunotherapy-naive ovarian cancer
- (2018) Sara Bobisse et al. Nature Communications
- A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti–PD-(L)1 and Anti–CTLA-4 in Preclinical Models
- (2018) Stephen B. Willingham et al. Cancer Immunology Research
- The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
- (2017) Bertrand Allard et al. IMMUNOLOGICAL REVIEWS
- Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
- (2017) Paul A. Beavis et al. JOURNAL OF CLINICAL INVESTIGATION
- Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma
- (2017) Si-Rui Ma et al. Molecular Cancer
- A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment
- (2017) Melanie Mediavilla-Varela et al. NEOPLASIA
- Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses
- (2016) Arabella Young et al. CANCER CELL
- Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis
- (2016) D. Mittal et al. CANCER RESEARCH
- A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer
- (2016) Stephen M Hatfield et al. CURRENT OPINION IN PHARMACOLOGY
- Emerging concepts of T cell metabolism as a target of immunotherapy
- (2016) Chih-Hao Chang et al. NATURE IMMUNOLOGY
- Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units
- (2016) Vanessa L. Wehbi et al. Frontiers in Immunology
- Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells
- (2016) Godehard Scholz et al. EBioMedicine
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis
- (2015) Yi Bao et al. JOURNAL OF CELL BIOLOGY
- Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
- (2014) C. Cekic et al. CANCER RESEARCH
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- High-throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry
- (2014) Filippos Porichis et al. Nature Communications
- Extracellular adenosine regulates naive T cell development and peripheral maintenance
- (2013) Caglar Cekic et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
- (2013) Patrick M Gubser et al. NATURE IMMUNOLOGY
- Rapid Perturbation in Viremia Levels Drives Increases in Functional Avidity of HIV-specific CD8 T Cells
- (2013) Selena Viganò et al. PLoS Pathogens
- CD73 promotes tumor growth and metastasis
- (2012) Bin Zhang OncoImmunology
- cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
- (2011) Jianling Xie et al. CELLULAR SIGNALLING
- Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
- (2011) A. Clayton et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control
- (2011) C. T. Berger et al. JOURNAL OF VIROLOGY
- Receptor desensitization and blockade of the suppressive effects of prostaglandin E2 and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes
- (2010) Yunyun Su et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
- (2010) Jonathan D. Powell et al. IMMUNITY
- The role of mTOR in memory CD8+ T-cell differentiation
- (2010) Koichi Araki et al. IMMUNOLOGICAL REVIEWS
- Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D
- (2010) H. W. Kim et al. MOLECULAR AND CELLULAR BIOLOGY
- Arginase: an emerging key player in the mammalian immune system
- (2009) Markus Munder BRITISH JOURNAL OF PHARMACOLOGY
- Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
- (2009) Carsten Linnemann et al. IMMUNOLOGY
- Anergic T Cells Are Metabolically Anergic
- (2009) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search