Review
Oncology
Thamizhselvi Ganapathy, Rajalingam Radhakrishnan, Seth Sakshi, Sunil Martin
Summary: Engineered immune cell therapy, specifically using gamma delta T cells, shows promise in modernizing oncology by treating malignancies that are resistant to conventional therapies. However, there are still challenges that need to be addressed, such as reducing toxicity, improving homing and in vivo persistence, and overcoming heterogeneity in order to fully utilize the potential of gamma delta T cells for cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Gitte Holmen Olofsson, Manja Idorn, Ana Micaela Carnaz Simoes, Pia Aehnlich, Signe Koggersbol Skadborg, Elfriede Noessner, Reno Debets, Bernhard Moser, Ozcan Met, Per Thor Straten
Summary: Human Vγ9Vδ2 T cells expanded in vitro efficiently kill cancer cells, have the ability to cross-present MHC class I-restricted peptides, and support tumor-specific CD8 T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ilse Gille, Frans H. J. Claas, Geert W. Haasnoot, Mirjam H. M. Heemskerk, Sebastiaan Heidt
Summary: Solid organ transplantation is an effective treatment for end-stage diseases, but the need for immunosuppression can lead to serious side effects. CAR Treg therapy, specifically with HLA-A2 CAR Tregs, shows potential in promoting transplantation tolerance and improving graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xiaochen Zhai, Fengtao You, Shufen Xiang, Licui Jiang, Dan Chen, Yafen Li, Shuangshuang Fan, Zhichao Han, Tingting Zhang, Gangli An, Bozhen Zhang, Yusheng Chen, Huimin Meng, Lin Yang
Summary: The study found that CAR-modified Vγ9Vδ2 T cells have anti-tumor activity against the MUC1-Tn antigen, with even stronger effects than CAR-alpha beta T cells. While CAR-Vγ9Vδ2 T cells have shorter persistence, their function can be improved with continuous stimulation.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Immunology
Wenyi Yan, Louisa S. Chard Dunmall, Nicholas R. Lemoine, Yaohe Wang, Yafeng Wang, Pengju Wang
Summary: This review discusses the heterogeneity of γδ T cells and their importance in cancer immunotherapy. γδ T cells possess unique tumor recognition and anti-tumor functions, and play a role in the tumor microenvironment. Understanding and effectively harnessing these diverse γδ T cell subpopulations is crucial for tumor-specific immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Nattaporn Phanthaphol, Chalermchai Somboonpatarakun, Kwanpirom Suwanchiwasiri, Thaweesak Chieochansin, Jatuporn Sujjitjoon, Sopit Wongkham, John Maher, Mutita Junking, Pa-thai Yenchitsomanus
Summary: CAR T cell therapy has shown efficacy in hematologic malignancies, but further investigation is needed for its application in solid tumors. The selection of target antigens highly expressed in cancer cells but not normal cells is crucial for successful immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cristina Aparicio, Marina Belver, Lucia Enriquez, Francisco Espeso, Lucia Nunez, Ana Sanchez, Miguel angel de la Fuente, Margarita Gonzalez-Vallinas
Summary: Colorectal cancer is a major global public health issue, and CAR-T cell therapy shows promise as a cancer treatment, but faces challenges in achieving success in solid tumors like colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian
Summary: This study aimed to identify the optimal single-chain variable fragment (scFv) to optimize the therapeutic potential of CAR-T cells targeting CEA-positive carcinoma. The study tested four different antibody-derived scFvs (M5A, hMN-14, BW431/26, and C2-45) and found that M5A had the best cell proliferation and cytokine secretion levels, as well as better antitumor efficacy in a mouse xenograft model.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Derek Lee, Carl J. Rosenthal, Natalie E. Penn, Zachary Spencer Dunn, Yang Zhou, Lili Yang
Summary: γδ (gamma delta) T cells are a minor population of T cells with both innate and adaptive immune properties. They can be activated independently of MHC, making them ideal for immunotherapy development. Gene editing technologies can enhance the antitumor functions of different subsets of γδ T cells.
Article
Oncology
Jinrong Yang, Weilin Zhou, Dan Li, Ting Niu, Wei Wang
Summary: This article summarizes the application and research progress of BCMA-targeting CAR T cell therapy in the treatment of multiple myeloma, as well as measures to improve efficacy and safety.
Review
Oncology
Samane Abbasi, Milad Asghari Totmaj, Masoumeh Abbasi, Saba Hajazimian, Pouya Goleij, Javad Behroozi, Behrouz Shademan, Alireza Isazadeh, Behzad Baradaran
Summary: Over the last decade, novel therapeutic approaches like CAR-T-cell immunotherapy have transformed the treatment perspective of human malignancies. However, this therapy is associated with side effects and faces challenges in manufacturing, engineering, applications, and toxicities. Further studies are needed to enhance efficacy and minimize adverse events.
Review
Oncology
Vicky Mengfei Qin, Criselle D'Souza, Paul J. Neeson, Joe Jiang Zhu
Summary: Chimeric antigen receptors (CAR) are engineered molecules that can recognize specific antigens and induce downstream signaling, primarily used in CAR-T cells to target and kill tumor cells. While CAR-T cell therapy has shown success in treating hematologic malignancies, current research is focusing on extending CAR technology to other immune cells for potential applications in solid tumors and autoimmune diseases. CAR technology is a powerful platform in immunotherapy with diverse applications beyond conventional CAR-T cells.
Article
Oncology
Piriya Luangwattananun, Mutita Junking, Jatuporn Sujjitjoon, Yupanun Wutti-in, Naravat Poungvarin, Chanitra Thuwajit, Pa-thai Yenchitsomanus
Summary: The study demonstrates the specificity of fourth-generation FR alpha-CAR T cells in lysing breast cancer cells and their anti-tumor activity in spheroid cultures.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Medicine, General & Internal
Hao-Chien Hung, Ming-Huei Fan, Daniel Wang, Carol H. Miao, Pong Su, Chao-Lien Liu
Summary: This study developed third-generation PAR1CAR-T cells using genetic engineering and demonstrated their anti-tumor activity against PDAC in vitro and in vivo. The findings provide a novel strategy for immunotherapy against PDAC.
Review
Immunology
Guanyu Qu, Shengli Wang, Zhenlong Zhou, Dawei Jiang, Aihua Liao, Jing Luo
Summary: This article summarizes the current knowledge of the γδT cell phenotype in various tissues in mice and humans, describing the similarities and differences of tissue-resident γδT cells in these two species.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Chaitra Ujjani, Mazyar Shadman, Ryan C. Lynch, Brian Tu, Philip A. Stevenson, Caitlin Grainger, Haiying Zhu, Joshua A. Hill, Meei-Li Huang, Leslie Nielsen, Christina Poh, Tyler Sorensen, Ajay K. Gopal, Edus H. Warren, Brian G. Till, Sydney Lee, Daria Gausman, Stephen D. Smith, Ted Gooley, Alex Greninger
Summary: This study found that SARS-CoV-2 vaccine efficacy was lower in chronic lymphocytic leukemia (CLL) patients, with decreased rates of seroconversion and lower antibody levels compared to healthy controls. The results from the Roche anti-S assay and neutralization activity were similar. Durable immune responses were observed up to six months, and booster shots were effective in improving the immune response in patients who had a response. The absence of normal B cells, commonly seen in CLL patients receiving certain treatments, was a strong predictor of lack of seroconversion.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
M. Lia Palomba, Brian G. Till, Steven I. Park, Franck Morschhauser, Guillaume Cartron, Reinhard Marks, Mahesh Shivhare, Wan-Jen Hong, Aparna Raval, Alice C. Chang, Elicia Penuel, Leslie L. Popplewell
Summary: This study assessed the safety, tolerability, and efficacy of atezolizumab plus obinutuzumab in patients with R/R DLBCL and FL. The combination treatment showed acceptable safety profile and demonstrated a certain level of efficacy in both FL and DLBCL cohorts.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Biochemistry & Molecular Biology
Zibing Wang, Yuqing Liu, Ling Peng, Brian Till, Yuwei Liao, Shumin Yuan, Xiang Yan, Lin Chen, Qiang Fu, Zhihai Qin
Summary: The role of B cells in the anti-tumor immune response is controversial. An increase in the number of B cells in the peripheral blood of some tumor patients has been associated with poor immunotherapy efficacy. This study suggests that CD11b(+) myeloid cells promote B cell proliferation, activation, and survival, and targeting B cells may increase the efficacy of immunotherapy in tumor-bearing hosts.
Article
Oncology
Mengchao An, Wenkang Wang, Jie Zhang, Brian G. Till, Lingdi Zhao, Hao Huang, Yonghao Yang, Tiepeng Li, Lu Han, Xiaojie Zhang, Peng Qin, Yunjian Wang, Min Zhang, Hong Cui, Quanli Gao, Zibing Wang
Summary: This study aimed to investigate the association between HBV DNA level, antiviral therapy, and survival outcomes in patients with advanced hepatocellular carcinoma (HCC) treated with anti-PD-1 immunotherapy. The results showed that HBV DNA level was not significantly associated with survival outcomes, but antiviral therapy significantly improved overall survival.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Shumin Yuan, Ling Peng, Yuqing Liu, Brian G. Till, Xiang Yan, Jie Zhang, Liping Zhu, Huijuan Wang, Shaokai Zhang, Hongle Li, Quanli Gao, Zibing Wang
Summary: Retrospective analysis suggests that low-dose anlotinib may be an effective and well-tolerated anti-angiogenesis partner for combination therapy in advanced non-small cell lung cancer (NSCLC) patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Correction
Neurosciences
Amir Hossein Mohammadi, Seyedvahid Seyedmoalemi, Mahsa Moghanlou, Seyed Amirreza Akhlagh, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Ameneh Jafari, Hamed Mirzaei
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Amir Hossein Mohammadi, Seyedvahid Seyedmoalemi, Mahsa Moghanlou, Seyed Amirreza Akhlagh, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Ameneh Jafari, Hamed Mirzaei
Summary: Synaptic plasticity refers to the ability of synapses to weaken or strengthen over time, with miRNAs playing crucial roles in regulating this process. Dysregulation of miRNAs may be associated with pathological alterations in synaptic plasticity, leading to diseases. Understanding the impact of miRNAs on synaptic plasticity provides insights for the diagnosis and treatment of related diseases and drug addiction.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Analytical
Hamed Mirzaei, Milad Ramezankhani, Emily Earl, Nishat Tasnim, Abbas S. Milani, Mina Hoorfar
Summary: In this study, a Sparse Autoencoder-based Transfer Learning (SAE-TL) framework was proposed to estimate the hydrogen gas concentration in HENG mixtures. By combining limited datasets from a 3D printed microfluidic detector and commercial MOS sensors, accurate detection of simulated HENG concentrations can be achieved.
Review
Medicine, Research & Experimental
Fahimeh Zamani Rarani, Bahman Rashidi, Mohammad Hassan Jafari Najaf Abadi, Michael R. Hamblin, Seyed Mohammad Reza Hashemian, Hamed Mirzaei
Summary: The COVID-19 pandemic is a global health emergency and there is currently no completely effective treatment. This review discusses the cytokines involved in the cytokine storm seen in severe COVID-19 patients and whether they can be used for treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Oncology
Amirhossein Davoodvandi, Sahand Sadeghi, Seyed Mohammad Amin Alavi, Seyedeh Shaghayegh Alavi, Ameneh Jafari, Haroon Khan, Michael Aschner, Hamed Mirzaei, Mehran Sharifi, Zatollah Asemi
Summary: Cancer is a serious health issue and drug therapy is commonly used for treatment. There is increasing interest in using natural compounds to overcome drug resistance and adverse reactions in cancer treatment. One such compound is berberine, which has a wide range of pharmacological activities and has shown anticancer effects on various gastrointestinal cancers. In this article, the therapeutic effects of berberine and its mechanisms on esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers are summarized.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Hematology
Ryan C. Lynch, Chaitra S. Ujjani, Christina Poh, Edus H. Warren, Stephen D. Smith, Mazyar Shadman, Brian Till, Vikram M. Raghunathan, Stefan Alig, Ash A. Alizadeh, Avanti Gulhane, Delphine L. Chen, Yolanda Tseng, Hilary Coye, Megan Shelby, Susan Ottemiller, Sarith Keo, Kaitlin Verni, Hongyan Du, Jacquelin Vandermeer, Ashley Gaston, Heather Rasmussen, Paul Martin, Edmond Marzbani, Jenna Voutsinas, Ajay K. Gopal
Summary: This study investigated the concurrent administration of pembrolizumab with chemotherapy in untreated classic Hodgkin lymphoma, showing promising safety and efficacy. Although some patients experienced adverse events, the overall response rate was 100% with a complete response rate of 90%.
Article
Chemistry, Medicinal
Mohammad Jaber MasodKhooy, Massoumeh Farasat, Mohamadreza Salehi Salmi, Hamed Mirzaei
Summary: This study evaluated the antitumor effect of a combination of Silybum marianum essential oils and 5-fluorouracil (5-FU) on hepatocellular carcinoma. The combination treatment significantly reduced migration, invasion, and angiogenesis, while also modulating apoptosis, autophagy, and NF-kappa B and Wnt pathway-related proteins. In vivo experiments showed that the combined treatment prolonged survival in a mouse model of hepatocellular carcinoma compared to either treatment alone.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Hamed Mirzaei, Jack McClelland, Devansh Sharma, Mohammad Arjmand, Mohammad H. H. Zarifi
Summary: This study focuses on investigating the real-time resonant microwave behavior of two polydimethylsiloxane (PDMS) structures in interaction with tetrahydrofuran (THF) and acetone, which are primary swelling agents. The interaction of the PDMS structures with target gases alters their structure, resulting in changes in the dielectric properties of the PDMS/gas system. Microwave resonators show substantial potential as versatile tools for investigating the physical changes in polymers during their interaction with gases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Immunology
Sasan Ghaffari, Mahshid Saleh, Behnia Akbari, Faezeh Ramezani, Hamid Reza Mirzaei
Summary: Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment, and single-cell analysis can provide valuable insights into the tumor microenvironment. Recent studies in CAR T cell therapy have shown that single-cell analysis can reveal key information.
Review
Biochemistry & Molecular Biology
Faezeh Ramezani, Ahmad Reza Panahi Meymandi, Behnia Akbari, Omid Reza Tamtaji, Hamed Mirzaei, Christine E. Brown, Hamid Reza Mirzaei
Summary: This review examines the role of trogocytosis in CAR NK/T cell therapy and its impact on cell function. By analyzing the effects of trogocytosis on NK and T cell activation, cytotoxicity, and antigen presentation, potential strategies to modulate trogocytosis for improved immunotherapy efficacy are proposed.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
