System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
出版年份 2022 全文链接
标题
System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 13, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-08-29
DOI
10.3389/fphar.2022.910292
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Multienzyme-like Reactivity Cooperatively Impairs Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy
- (2022) Ke Li et al. ACS Nano
- METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification
- (2022) Yiming Xu et al. Cancer Cell International
- Sanguinarine represses the growth and metastasis of non-small cell lung cancer by facilitating ferroptosis
- (2022) Rongzhong Xu et al. CURRENT PHARMACEUTICAL DESIGN
- Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4
- (2022) Wen Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- RNA-Seq Explores the Mechanism of Oxygen-Boosted Sonodynamic Therapy Based on All-in-One Nanobubbles to Enhance Ferroptosis for the Treatment of HCC
- (2022) Yichi Chen et al. International Journal of Nanomedicine
- Ferroptosis‐related gene NOX4 , CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma
- (2022) Ruoxi Xiao et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma
- (2022) Yiran Chen et al. Molecular Cancer
- Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT‑dependent ferroptosis pathway
- (2022) Liyi Zhang et al. Oncology Letters
- Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis
- (2022) Hsin-Chih Chen et al. Antioxidants
- Glutathione Depletion‐Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor
- (2022) Zhanwei Zhou et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis
- (2022) Zhanke He et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- From DNMT1 degrader to ferroptosis promoter: Drug repositioning of 6-Thioguanine as a ferroptosis inducer in gastric cancer
- (2022) Jinping Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Alloimperatorin activates apoptosis, ferroptosis and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro
- (2022) Jing Zhang et al. Biochemistry and Cell Biology
- Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer
- (2022) Xiuchao Wang et al. CANCER RESEARCH
- Importance of STAT3 signalling in cancer, metastasis and therapeutic interventions
- (2022) Mohamed El-Tanani et al. CELLULAR SIGNALLING
- Ferroptosis triggered by dihydroartemisinin facilitates chlorin e6 induced photodynamic therapy against lung cancer through inhibiting GPX4 and enhancing ROS
- (2022) Ning Han et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Sinapine induced ferroptosis in non-small cell lung cancer cells by upregulating transferrin/transferrin receptor and downregulating SLC7A11
- (2022) Min Shao et al. GENE
- Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma
- (2022) Jun-Kyu Byun et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells
- (2022) Xing Du et al. Journal of Zhejiang University-SCIENCE B
- Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis
- (2022) Feng-guo Zhai et al. PHARMACEUTICAL BIOLOGY
- Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells
- (2022) Ara Jo et al. Cell Death & Disease
- A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers
- (2022) Pranavi Koppula et al. Nature Communications
- Tetrandrine Citrate Suppresses Breast Cancer via Depletion of Glutathione Peroxidase 4 and Activation of Nuclear Receptor Coactivator 4-Mediated Ferritinophagy
- (2022) Jiameng Yin et al. Frontiers in Pharmacology
- Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer
- (2022) Shumin Ouyang et al. Redox Biology
- Solasonine Causes Redox Imbalance and Mitochondrial Oxidative Stress of Ferroptosis in Lung Adenocarcinoma
- (2022) Yao-Ying Zeng et al. Frontiers in Oncology
- Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells
- (2022) Xiaoli Zhang et al. Frontiers in Oncology
- Solasonine Inhibits Pancreatic Cancer Progression With Involvement of Ferroptosis Induction
- (2022) Xiaoqiang Liang et al. Frontiers in Oncology
- Propofol Inhibits Proliferation and Augments the Anti-Tumor Effect of Doxorubicin and Paclitaxel Partly Through Promoting Ferroptosis in Triple-Negative Breast Cancer Cells
- (2022) Chen Sun et al. Frontiers in Oncology
- CircP4HB regulates ferroptosis via SLC7A11-mediated glutathione synthesis in lung adenocarcinoma
- (2022) Chun-Feng Pan et al. Translational Lung Cancer Research
- N 6 ‐methyladenosine‐RNA methylation promotes expression of solute carrier family 7 member 11, an uptake transporter of cystine for lipid reactive oxygen species scavenger glutathione synthesis, leading to hepatoblastoma ferroptosis resistance
- (2022) Ronald A. Hill et al. Clinical and Translational Medicine
- The N6‐methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma
- (2022) Li Liu et al. Clinical and Translational Medicine
- Connecting N6‐methyladenosine modification to ferroptosis resistance in hepatoblastoma
- (2022) Wan‐Xin Peng et al. Clinical and Translational Medicine
- The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells
- (2022) Tanu Singh et al. Cell Death Discovery
- PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma
- (2022) Yating Liu et al. ONCOGENE
- Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer
- (2022) Han Li et al. PHARMACOLOGICAL RESEARCH
- Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells
- (2022) Gilles Rademaker et al. Redox Biology
- Design, synthesis of isothiocyanate‐containing hybrid androgen receptor (AR) antagonist to downregulate AR and induce ferroptosis in GSH–deficient prostate cancer cells
- (2021) Zhihui Qin et al. Chemical Biology & Drug Design
- Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells
- (2021) Yahui Ding et al. Journal of Hematology & Oncology
- A Marine Terpenoid, Heteronemin, Induces Both the Apoptosis and Ferroptosis of Hepatocellular Carcinoma Cells and Involves the ROS and MAPK Pathways
- (2021) Wen-Tsan Chang et al. Oxidative Medicine and Cellular Longevity
- Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer
- (2021) Yifeng Hou et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Integrative genomic analysis of gemcitabine resistance in pancreatic cancer by patient-derived xenograft models
- (2021) Gang Yang et al. CLINICAL CANCER RESEARCH
- Apatinib induced ferroptosis by lipid peroxidation in gastric cancer
- (2021) Liying Zhao et al. Gastric Cancer
- Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy
- (2021) Xianchuang Liu et al. International Journal of Nanomedicine
- Broadening horizons: the role of ferroptosis in cancer
- (2021) Xin Chen et al. Nature Reviews Clinical Oncology
- mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
- (2021) Yilei Zhang et al. Nature Communications
- NUPR1 is a critical repressor of ferroptosis
- (2021) Jiao Liu et al. Nature Communications
- Curcumin induces ferroptosis in non‐small‐cell lung cancer via activating autophagy
- (2021) Xin Tang et al. Thoracic Cancer
- Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin
- (2021) Changshun Yang et al. Aging-US
- KDM4A-mediated histone demethylation of SLC7A11 inhibits cell ferroptosis in osteosarcoma
- (2021) Meng Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549
- (2021) Shi-hua Deng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation
- (2021) Shuai-Jiang Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Targeting SLC3A2 subunit of system XC− is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma
- (2021) Lifang Ma et al. FREE RADICAL BIOLOGY AND MEDICINE
- CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma
- (2021) Zhixian Wang et al. ONCOLOGY REPORTS
- GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
- (2021) Qiujie Wang et al. Cell Death & Disease
- Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT
- (2021) Yulu Zhou et al. Frontiers in Pharmacology
- Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer
- (2021) Ying Liu et al. Acta Pharmaceutica Sinica B
- A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells
- (2021) Willian Meira et al. Cancers
- Targeting histone deacetylase enhances the therapeutic effect of Erastin-induced ferroptosis in EGFR-activating mutant lung adenocarcinoma
- (2021) Tuo Zhang et al. Translational Lung Cancer Research
- Acidity‐Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer
- (2021) Rundi Song et al. ADVANCED MATERIALS
- Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells
- (2021) Jiangwei Ni et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dihydroisotanshinone I induced ferroptosis and apoptosis of lung cancer cells
- (2021) Ching-Yuan Wu et al. BIOMEDICINE & PHARMACOTHERAPY
- Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
- (2021) Xinbo Wang et al. CANCER RESEARCH
- Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling
- (2021) Dazhi Fu et al. CELLULAR & MOLECULAR BIOLOGY LETTERS
- Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer
- (2021) Nazia Chaudhary et al. INTERNATIONAL JOURNAL OF CANCER
- Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer
- (2021) Jingjing Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cell death in pancreatic cancer: from pathogenesis to therapy
- (2021) Xin Chen et al. Nature Reviews Gastroenterology & Hepatology
- Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4
- (2021) Guan-Nan He et al. Drug Design Development and Therapy
- MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis
- (2021) Haiwei Ni et al. Stem Cell Research & Therapy
- pH‐Sensitive Molecular‐Switch‐Containing Polymer Nanoparticle for Breast Cancer Therapy with Ferritinophagy‐Cascade Ferroptosis and Tumor Immune Activation
- (2021) Tiantian Zuo et al. Advanced Healthcare Materials
- Levobupivacaine Induces Ferroptosis by miR-489-3p/SLC7A11 Signaling in Gastric Cancer
- (2021) Shun-Hong Mao et al. Frontiers in Pharmacology
- Orlistat induces ferroptosis-like cell death of lung cancer cells
- (2021) Wenjing Zhou et al. Frontiers of Medicine
- CircDTL Functions as an Oncogene and Regulates Both Apoptosis and Ferroptosis in Non-small Cell Lung Cancer Cells
- (2021) Wang Shanshan et al. Frontiers in Genetics
- Knockdown of SFRS9 Inhibits Progression of Colorectal Cancer Through Triggering Ferroptosis Mediated by GPX4 Reduction
- (2021) Rui Wang et al. Frontiers in Oncology
- Ketamine suppresses proliferation and induces ferroptosis and apoptosis of breast cancer cells by targeting KAT5/GPX4 axis
- (2021) Huixin Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer
- (2021) Shunv Cai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeted therapy for drug-tolerant persister cells after imatinib treatment for gastrointestinal stromal tumours
- (2021) Tomo Ishida et al. BRITISH JOURNAL OF CANCER
- SLC7A11/ xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells
- (2021) Poonam Yadav et al. CANCER LETTERS
- Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy
- (2021) Xue Liu et al. DRUG DELIVERY
- YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis
- (2021) Ruize Gao et al. EMBO Molecular Medicine
- Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis
- (2021) Haiwei Ni et al. ENVIRONMENTAL TOXICOLOGY
- Hemin enhances radiosensitivity of lung cancer cells through ferroptosis
- (2021) Waleed Abdelbagi Almahi et al. EXPERIMENTAL CELL RESEARCH
- Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2‐dependent silencing of SLC7A11
- (2021) Zhuoyang Fan et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- CircGFRA1 facilitates the malignant progression of HER‐2‐positive breast cancer via acting as a sponge of miR‐1228 and enhancing AIFM2 expression
- (2021) Meiheban Bazhabayi et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism
- (2021) Zhao Cui et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Metal‐Polyphenol‐Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification
- (2021) Lulu Zhou et al. Small
- ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma
- (2021) Wenbin Huang et al. NEOPLASIA
- Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- (2021) Xueying Ren et al. Redox Biology
- MiR-27a-3p Promotes Non-Small Cell Lung Cancer Through SLC7A11-Mediated-Ferroptosis
- (2021) Xuan Lu et al. Frontiers in Oncology
- Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells
- (2021) Yongfei He et al. Annals of Translational Medicine
- Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers
- (2020) Ling F. Ye et al. ACS Chemical Biology
- Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
- (2020) Lian‐Dong Shen et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
- (2020) Yishu Wang et al. FEBS Open Bio
- Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy
- (2020) Tian Xu et al. ACS Nano
- GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression
- (2020) Liang Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death
- (2020) Yang Liu et al. CANCER GENE THERAPY
- Lipid peroxidation and ferroptosis: The role of GSH and GPx4
- (2020) Fulvio Ursini et al. FREE RADICAL BIOLOGY AND MEDICINE
- Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
- (2020) John K. Eaton et al. Nature Chemical Biology
- Cysteine depletion induces pancreatic tumor ferroptosis in mice
- (2020) Michael A. Badgley et al. SCIENCE
- TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells
- (2020) Do Hyung Kim et al. Cell Death & Disease
- xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner
- (2020) Keiko Miyamoto et al. Cancers
- Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma
- (2020) Zhong-jie Li et al. ACTA PHARMACOLOGICA SINICA
- Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression
- (2020) Zhuowei Gao et al. BIOMEDICINE & PHARMACOTHERAPY
- Tanshinone IIA induces ferroptosis in gastric cancer cells through p53 mediated-SLC7A11 down-regulation
- (2020) Zhenhua Guan et al. BIOSCIENCE REPORTS
- Erastin induces apoptotic and ferroptotic cell death by inducing ROS accumulation by causing mitochondrial dysfunction in gastric cancer cell HGC‑27
- (2020) Yingwei Sun et al. Molecular Medicine Reports
- LncRNA SLC7A11-AS1 Contributes to Lung Cancer Progression Through Facilitating TRAIP Expression by Inhibiting miR-4775
- (2020) Yongmin Liu et al. OncoTargets and Therapy
- Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells
- (2020) Li Yang et al. Frontiers in Oncology
- Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system
- (2020) Mingming Jin et al. BIOMEDICINE & PHARMACOTHERAPY
- Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells
- (2020) Kang Wang et al. CELL DEATH AND DIFFERENTIATION
- Lymph protects metastasizing melanoma cells from ferroptosis
- (2020) Jessalyn M. Ubellacker et al. NATURE
- Dihydroartemisinin Inhibits the Proliferation, Colony Formation and Induces Ferroptosis of Lung Cancer Cells by Inhibiting PRIM2/SLC7A11 Axis
- (2020) Bing Yuan et al. OncoTargets and Therapy
- Oxidative Damage and Antioxidant Defense in Ferroptosis
- (2020) Feimei Kuang et al. Frontiers in Cell and Developmental Biology
- RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer
- (2020) Yueyue Yang et al. Cancer Cell International
- Ferroptosis: molecular mechanisms and health implications
- (2020) Daolin Tang et al. CELL RESEARCH
- Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane
- (2020) Yuko Iida et al. Oncology Letters
- Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
- (2020) Enyong Dai et al. Nature Communications
- Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib
- (2020) Xiang Song et al. Frontiers in Oncology
- RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA
- (2020) Qi Wang et al. EXPERIMENTAL CELL RESEARCH
- NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
- (2019) Matthew Dodson et al. Redox Biology
- A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity
- (2019) Jennifer Yinuo Cao et al. Cell Reports
- Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA
- (2019) Min Wang et al. CELL DEATH AND DIFFERENTIATION
- The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11
- (2019) Tong Liu et al. CANCER RESEARCH
- Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers
- (2019) Hideaki Ogiwara et al. CANCER CELL
- Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
- (2019) Ishraq Alim et al. CELL
- Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
- (2019) Yufei Wang et al. EMBO REPORTS
- Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells
- (2019) Shiyao Sui et al. Cell Death & Disease
- Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
- (2019) Boutaina Daher et al. CANCER RESEARCH
- Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism
- (2019) Po-Han Chen et al. CELL DEATH AND DIFFERENTIATION
- ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–
- (2019) Liyuan Wang et al. CELL DEATH AND DIFFERENTIATION
- Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor
- (2019) Haochen Yu et al. ONCOLOGY REPORTS
- A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
- (2019) Yilong Zou et al. Nature Communications
- Ferroptosis is governed by differential regulation of transcription in liver cancer
- (2019) Xiao Zhang et al. Redox Biology
- BHQ-Cyanine Based “Off-On” Long-Circulating Assembly as Ferroptosis Amplifier for Cancer Treatment: a Lipid-Peroxidation Burst Device
- (2019) Mangmang Sang et al. ACS Applied Materials & Interfaces
- STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma
- (2019) Yuanyang Lai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells
- (2019) Tao Bai et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin
- (2019) Xuefei Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
- (2019) Gloria E. Villalpando-Rodriguez et al. Oxidative Medicine and Cellular Longevity
- The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma
- (2019) Wen-Hsuan Yang et al. Cell Reports
- Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells
- (2019) Mengyu Yu et al. CANCER SCIENCE
- O-GlcNAcylated c-Jun antagonizes ferroptosis via inhibiting GSH synthesis in liver cancer
- (2019) Yan Chen et al. CELLULAR SIGNALLING
- Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε
- (2019) Ana‐Marija Vučković et al. FEBS LETTERS
- Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1
- (2019) Hironari Nishizawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- Erastin/sorafenib induces cisplatin‑resistant non‑small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway
- (2019) Yu Li et al. Oncology Letters
- Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
- (2019) Yu-Shih Lin et al. Frontiers in Pharmacology
- Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells
- (2019) Hai Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells
- (2019) Hongxia Tang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma
- (2019) Kewen Hu et al. JOURNAL OF CLINICAL INVESTIGATION
- GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues
- (2018) Matilde Maiorino et al. ANTIOXIDANTS & REDOX SIGNALING
- Fighting breast cancer stem cells through the immune-targeting of the xCT cystine–glutamate antiporter
- (2018) Roberto Ruiu et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction
- (2018) Michael J. Kerins et al. CANCER SCIENCE
- Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
- (2018) Irina Ingold et al. CELL
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
- (2018) Yuki Yamaguchi et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Cisplatin-Based First-Line Treatment of Elderly Patients With Advanced Non–Small-Cell Lung Cancer: Joint Analysis of MILES-3 and MILES-4 Phase III Trials
- (2018) Cesare Gridelli et al. JOURNAL OF CLINICAL ONCOLOGY
- Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4
- (2018) Cong Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
- (2018) Michael M. Gaschler et al. Nature Chemical Biology
- Fighting Resilient Cancers with Iron
- (2018) Jonathan J. Chen et al. TRENDS IN CELL BIOLOGY
- The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
- (2018) Mami Sato et al. Scientific Reports
- Ferroptosis: A Novel Anti-tumor Action for Cisplatin
- (2018) Jipeng Guo et al. Cancer Research and Treatment
- Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells
- (2018) Ubaid Ullah et al. Cell Reports
- BECN1 is a new driver of ferroptosis
- (2018) Rui Kang et al. Autophagy
- AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity
- (2018) Xinxin Song et al. CURRENT BIOLOGY
- BAP1 links metabolic regulation of ferroptosis to tumour suppression
- (2018) Yilei Zhang et al. NATURE CELL BIOLOGY
- Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells
- (2018) Gaetano Donofrio et al. OncoImmunology
- Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics
- (2018) Shuaifei Wang et al. ACS Nano
- CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells
- (2018) Sayo Horibe et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer
- (2018) Daiha Shin et al. FREE RADICAL BIOLOGY AND MEDICINE
- TGF-β as Multifaceted Orchestrator in HCC Progression: Signaling, EMT, Immune Microenvironment, and Novel Therapeutic Perspectives
- (2018) Serena Mancarella et al. SEMINARS IN LIVER DISEASE
- RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
- (2018) Xinbing Sui et al. Frontiers in Pharmacology
- The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production
- (2017) Jaeyong Lee et al. EXPERIMENTAL CELL RESEARCH
- Breast cancer
- (2017) Nadia Harbeck et al. LANCET
- NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
- (2017) Delin Chen et al. MOLECULAR CELL
- NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
- (2017) Samantha W. Alvarez et al. NATURE
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- (2017) Vasanthi S. Viswanathan et al. NATURE
- ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
- (2017) D Chen et al. ONCOGENE
- Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells
- (2017) Shumei Ma et al. PLoS One
- The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells
- (2017) Zohreh Mostafavi-Pour et al. Oncology Letters
- CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway
- (2017) Meng-Shian Chen et al. Oncotarget
- EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes
- (2017) Yiqun Jiang et al. Theranostics
- Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability
- (2017) Jiantao Jia et al. Theranostics
- RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis
- (2017) Ryo Sato et al. Biomed Research International
- Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
- (2017) Z Fan et al. Oncogenesis
- Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells
- (2017) Shihui Hao et al. NEOPLASIA
- A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo
- (2017) Elisabetta Bolli et al. OncoImmunology
- Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines
- (2017) Yuki Haga et al. PLoS One
- The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(--)
- (2016) K. Tsuchihashi et al. CANCER RESEARCH
- The integrated stress response
- (2016) Karolina Pakos‐Zebrucka et al. EMBO REPORTS
- An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model
- (2016) Matthew Jennis et al. GENES & DEVELOPMENT
- Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis
- (2016) Xiaofang Sun et al. HEPATOLOGY
- Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib
- (2016) Aline Houessinon et al. Molecular Cancer
- Glutathione peroxidase 4: a new player in neurodegeneration?
- (2016) B R Cardoso et al. MOLECULAR PSYCHIATRY
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- (2016) Valerian E Kagan et al. Nature Chemical Biology
- Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
- (2016) Kenichi Shimada et al. Nature Chemical Biology
- Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
- (2016) Shira L Cramer et al. NATURE MEDICINE
- Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells
- (2016) Takashi Kasukabe et al. ONCOLOGY REPORTS
- Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
- (2016) Wan Seok Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells
- (2016) S Ma et al. Cell Death & Disease
- Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
- (2016) Masanori Hasegawa et al. Oncotarget
- Activation of c-Jun predicts a poor response to sorafenib in hepatocellular carcinoma: Preliminary Clinical Evidence
- (2016) Wei Chen et al. Scientific Reports
- Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration
- (2016) Bradley A. Carlson et al. Redox Biology
- Regulation of Selenium Metabolism and Transport
- (2015) Raymond F. Burk et al. Annual Review of Nutrition
- Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility
- (2015) Marie-Helene Larraufie et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells
- (2015) Christophe Louandre et al. CANCER LETTERS
- Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
- (2015) M Hayano et al. CELL DEATH AND DIFFERENTIATION
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
- (2015) Robert S. Jansen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
- (2015) Mai Matsushita et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Glutaminolysis and Transferrin Regulate Ferroptosis
- (2015) Minghui Gao et al. MOLECULAR CELL
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress
- (2015) Eric Habib et al. Redox Biology
- Mitochondrial iron–sulfur protein biogenesis and human disease
- (2014) Oliver Stehling et al. BIOCHIMIE
- miR-375 inhibits Helicobacter pylori-induced gastric carcinogenesis by blocking JAK2–STAT3 signaling
- (2014) Lin Miao et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Colorectal Cancer Stem Cells: From the Crypt to the Clinic
- (2014) Ann Zeuner et al. Cell Stem Cell
- Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways
- (2014) Weishi Yu et al. GENOME RESEARCH
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- (2014) Jose Pedro Friedmann Angeli et al. NATURE CELL BIOLOGY
- Wearing Red for Signaling: The Heme-Bach Axis in Heme Metabolism, Oxidative Stress Response and Iron Immunology
- (2014) Kazuhiko Igarashi et al. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- (2014) Scott J Dixon et al. eLife
- Role of Nrf2 in Oxidative Stress and Toxicity
- (2013) Qiang Ma Annual Review of Pharmacology and Toxicology
- Mammalian Trit1 is a tRNA[Ser]Sec-isopentenyl transferase required for full selenoprotein expression
- (2013) Noelia Fradejas et al. BIOCHEMICAL JOURNAL
- Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
- (2013) Luika A. Timmerman et al. CANCER CELL
- Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice
- (2013) Markus Wortmann et al. CIRCULATION RESEARCH
- Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib
- (2013) Christophe Louandre et al. INTERNATIONAL JOURNAL OF CANCER
- The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
- (2012) Jan Lewerenz et al. ANTIOXIDANTS & REDOX SIGNALING
- Glutathione synthesis
- (2012) Shelly C. Lu BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
- (2012) Marcel Deponte BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC- Transporter Using Positron Emission Tomography in Patients with Non-Small Cell Lung or Breast Cancer
- (2012) S. Baek et al. CLINICAL CANCER RESEARCH
- The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements
- (2012) Arindam Pal et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Constitutive Notch2 signaling induces hepatic tumors in mice
- (2012) Michael T. Dill et al. HEPATOLOGY
- The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond
- (2011) Marcus Conrad et al. AMINO ACIDS
- CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
- (2011) Takatsugu Ishimoto et al. CANCER CELL
- Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells
- (2011) Takashi Ueta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
- (2011) Adam Lister et al. Molecular Cancer
- LSH and G9a/GLP complex are required for developmentally programmed DNA methylation
- (2010) K. Myant et al. GENOME RESEARCH
- System xc−and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency
- (2010) Pankaj Kumar Mandal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice
- (2009) Hirotaka Imai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ATF4-dependent transcription mediates signaling of amino acid limitation
- (2009) Michael S. Kilberg et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels
- (2008) M. H. Stipanuk et al. AMINO ACIDS
- Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
- (2008) Alexander Seiler et al. Cell Metabolism
- Regulation of glutathione synthesis
- (2008) Shelly C. Lu MOLECULAR ASPECTS OF MEDICINE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now