Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

Aspirin plus sorafenib potentiates cisplatin cytotoxicity in resistant head and neck cancer cells through xCT inhibition

(2017) Jong-Lyel Roh et al.   FREE RADICAL BIOLOGY AND MEDICINE

PRG3 induces Ras-dependent oncogenic cooperation in gliomas

(2016) Zheng Fan et al.   Oncotarget

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

(2016) Tina Sehm et al.   Oncotarget

Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma

(2016) Jiang Chen et al.   Cancer Medicine

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

(2015) Maria A. O’Connell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight

(2015) Nicolai Savaskan et al.   Current Neuropharmacology

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress

(2015) Eric Habib et al.   Redox Biology

To "Grow" or "Go": TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN

(2014) D. J. Shiwarski et al.   CLINICAL CANCER RESEARCH

Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition

(2014) P. Ye et al.   MOLECULAR AND CELLULAR BIOLOGY

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Paradoxical Role of Nrf2 in Tumor Biology

(2013) Hui Shen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Oncogenic functions of the transcription factor Nrf2

(2013) Irene Gañán-Gómez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The Effects of Nrf2 on Tumor Angiogenesis: A Review of the Possible Mechanisms of Action

(2012) Suna Zhou et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The involvement of Nrf2–ARE pathway in regulation of apoptosis in human glioblastoma cell U251

(2012) Hao Pan et al.   NEUROLOGICAL RESEARCH

Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer

(2011) Xiangdong Ma et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

(2011) Adam Lister et al.   Molecular Cancer

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

xCT modulation in gliomas: Relevance to energy metabolism and tumor microenvironment normalization

(2010) Nic E. Savaskan et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Acquired Cisplatin Resistance in Human Lung Adenocarcinoma Cells Is Associated with Enhanced Autophagy

(2010) Jing-Hua Ren et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Plasticity-related Gene 5 (PRG5) Induces Filopodia and Neurite Growth and Impedes Lysophosphatidic Acid– and Nogo-A–mediated Axonal Retraction

(2009) Thomas Broggini et al.   MOLECULAR BIOLOGY OF THE CELL

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

(2008) Nicolai E Savaskan et al.   NATURE MEDICINE

Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling

(2008) N M Reddy et al.   ONCOGENE

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH