Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

(2020) Haiyang Zhang et al.   Molecular Cancer

Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer

(2020) Chao Wang et al.   Aging-US

Gastric cancer

(2020) Elizabeth C Smyth et al.   LANCET

Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

(2020) Zhuanzhuan Qiang et al.   Oxidative Medicine and Cellular Longevity

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

The Induction of Ferroptosis by Impairing STAT3/Nrf2/GPx4 Signaling Enhances the Sensitivity of Osteosarcoma Cells to Cisplatin

(2019) Qiang Liu et al.   CELL BIOLOGY INTERNATIONAL

Targeting STAT3 inhibition to reverse cisplatin resistance

(2019) Chao-Yue Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

(2019) Haibin Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ferroptosis is a lysosomal cell death process

(2018) Huan Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

(2018) Tianyi Wang et al.   Cell Metabolism

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer

(2018) Seung Tae Kim et al.   NATURE MEDICINE

Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein

(2018) Wen-ting He et al.   Chinese Journal of Integrative Medicine

Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

(2018) Matteo Menotti et al.   NATURE MEDICINE

The α6β4 integrin promotes resistance to ferroptosis

(2017) Caitlin W. Brown et al.   JOURNAL OF CELL BIOLOGY

Adjuvant Chemoradiotherapy With Epirubicin, Cisplatin, and Fluorouracil Compared With Adjuvant Chemoradiotherapy With Fluorouracil and Leucovorin After Curative Resection of Gastric Cancer: Results From CALGB 80101 (Alliance)

(2017) Charles S. Fuchs et al.   JOURNAL OF CLINICAL ONCOLOGY

The complex roles of STAT3 and STAT5 in maintaining redox balance: Lessons from STAT-mediated xCT expression in cancer cells

(2017) Katja Linher-Melville et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Progress in the treatment of advanced gastric cancer

(2017) Zheyu Song et al.   TUMOR BIOLOGY

Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression

(2016) Weicheng Wang et al.   BIOCHEMICAL PHARMACOLOGY

Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer

(2016) Jong-Lyel Roh et al.   CANCER LETTERS

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo

(2015) P. Yue et al.   CANCER RESEARCH

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies

(2015) Michinori Ogura et al.   CANCER SCIENCE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors

(2015) Do-Youn Oh et al.   Cancer Research and Treatment

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

(2015) Huiqin Zhong et al.   Redox Biology

Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors

(2014) Johanna C. Bendell et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

(2013) X. Zhang et al.   CANCER RESEARCH

Management of gastric cancer in Asia: resource-stratified guidelines

(2013) Lin Shen et al.   LANCET ONCOLOGY

Down-Regulation of BAX Gene During Carcinogenesis and Acquisition of Resistance to 5-FU in Colorectal Cancer

(2013) Mehdi Manoochehri et al.   PATHOLOGY & ONCOLOGY RESEARCH

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

(2011) L. V. Sequist et al.   Science Translational Medicine

A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes

(2010) Xiaolei Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Identification of a New Series of STAT3 Inhibitors by Virtual Screening

(2010) Kenji Matsuno et al.   ACS Medicinal Chemistry Letters

A Quantitative Model of Thermal Stabilization and Destabilization of Proteins by Ligands

(2008) Piotras Cimmperman et al.   BIOPHYSICAL JOURNAL