Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Border between natural product and drug: Comparison of the related benzoquinones idebenone and coenzyme Q10

(2015) Nuri Gueven et al.   Redox Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing

(2014) J H Song et al.   ONCOGENE

Growth Factor Priming Differentially Modulates Components of the Extracellular Matrix Proteome in Chondrocytes and Synovium-Derived Stem Cells

(2014) Elena Alegre-Aguarón et al.   PLoS One

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Structural insights into the catalytic mechanism of human squalene synthase

(2014) Chia-I Liu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mammalian Trit1 is a tRNA[Ser]Sec-isopentenyl transferase required for full selenoprotein expression

(2013) Noelia Fradejas et al.   BIOCHEMICAL JOURNAL

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Liquid Chromatography–High Resolution Mass Spectrometry Analysis of Fatty Acid Metabolism

(2011) Jurre J. Kamphorst et al.   ANALYTICAL CHEMISTRY

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

ChemMine tools: an online service for analyzing and clustering small molecules

(2011) T. W. H. Backman et al.   NUCLEIC ACIDS RESEARCH

Modulatory profiling identifies mechanisms of small molecule-induced cell death

(2011) A. J. Wolpaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases

(2010) Heather A. Hirsch et al.   CANCER CELL

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology