Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

(2020) Suman Mukhopadhyay et al.   CANCER RESEARCH

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes

(2019) Elina Urpilainen et al.   TUMOR BIOLOGY

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Regulation of lipid peroxidation and ferroptosis in diverse species

(2018) Marcus Conrad et al.   GENES & DEVELOPMENT

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pleiotropic Effects of Metformin on Cancer

(2018) Hans-Juergen Schulten   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Metformin plus chemotherapy versus chemotherapy alone in the first-line treatment of HER2-negative metastatic breast cancer. The MYME randomized, phase 2 clinical trial

(2018) O. Nanni et al.   BREAST CANCER RESEARCH AND TREATMENT

Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics

(2018) Bram Stynen et al.   CELL

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

(2018) Saul Soberanes et al.   Cell Metabolism

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Impact of Diabetes, Insulin, and Metformin Use on the Outcome of Patients With Human Epidermal Growth Factor Receptor 2–Positive Primary Breast Cancer: Analysis From the ALTTO Phase III Randomized Trial

(2017) Amir Sonnenblick et al.   JOURNAL OF CLINICAL ONCOLOGY

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients

(2017) Zhiguang Xiao et al.   NEOPLASIA

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metformin alters DNA methylation genome-wide via the H19/SAHH axis

(2016) T Zhong et al.   ONCOGENE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

(2015) Puyu Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells

(2015) Suman Mukhopadhyay et al.   CELL CYCLE

Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer

(2015) CONG FAN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal Regulation of AMP-activated Protein Kinase and Phospholipase D

(2015) Suman Mukhopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase

(2015) Jichun Zhou et al.   Nature Communications

UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development

(2015) Yafei Cai et al.   PLoS Genetics

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The role of mitochondria in cytosolic-nuclear iron–sulfur protein biogenesis and in cellular iron regulation

(2014) Roland Lill et al.   CURRENT OPINION IN MICROBIOLOGY

Modification of ASC1 by UFM1 Is Crucial for ERα Transactivation and Breast Cancer Development

(2014) Hee Min Yoo et al.   MOLECULAR CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells

(2014) Eveline A. I. F. Queiroz et al.   PLoS One

The Ufm1 Cascade

(2014) Jens Daniel et al.   Cells

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Involvement of ferritin heavy chain in the preventive effect of metformin against doxorubicin-induced cardiotoxicity

(2012) Mari C. Asensio-López et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice

(2011) Kanako Tatsumi et al.   Nature Communications

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism

(2009) Shinichi Ota et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Novel Type of E3 Ligase for the Ufm1 Conjugation System

(2009) Kanako Tatsumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

(2009) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

(2008) R-S Chen et al.   ONCOGENE