Fighting breast cancer stem cells through the immune-targeting of the xCT cystine–glutamate antiporter

The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain

(2018) Sigrid Ottestad-Hansen et al.   GLIA

Cancer immunotherapy beyond immune checkpoint inhibitors

(2018) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway

(2017) Eun Sil Kang et al.   FREE RADICAL RESEARCH

Production of virus-like particles for vaccines

(2017) J. Fuenmayor et al.   New Biotechnology

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis

(2017) Federica Fusella et al.   Nature Communications

Virus like particles as a platform for cancer vaccine development

(2017) Hui Kian Ong et al.   PeerJ

A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo

(2017) Elisabetta Bolli et al.   OncoImmunology

NK cells control breast cancer and related cancer stem cell hematological spread

(2017) Rossana Tallerico et al.   OncoImmunology

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

(2016) Kimberly J. Briggs et al.   CELL

The bad seed: Cancer stem cells in tumor development and resistance

(2016) Elle Koren et al.   DRUG RESISTANCE UPDATES

L-Ferritin targets breast cancer stem cells and delivers therapeutic and imaging agents

(2016) Laura Conti et al.   Oncotarget

Different applications of virus-like particles in biology and medicine: Vaccination and delivery systems

(2015) Zeinab Shirbaghaee et al.   BIOPOLYMERS

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

(2015) Ming-zhe Ma et al.   CANCER LETTERS

Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer

(2015) S. Lanzardo et al.   CANCER RESEARCH

Molecular mechanisms for enhanced DNA vaccine immunogenicity

(2015) Lei Li et al.   Expert Review of Vaccines

Inhibition of SystemXc−Transporter Attenuates Autoimmune Inflammatory Demyelination

(2015) Kirsten S. Evonuk et al.   JOURNAL OF IMMUNOLOGY

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Bovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2+ mammary cancer

(2015) Sarah Jacca et al.   OncoImmunology

SCA-1 Identifies the Tumor-Initiating Cells in Mammary Tumors of BALB-neuT Transgenic Mice

(2015) Cristina Grange et al.   NEOPLASIA

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

Immunotherapy of cancer stem cells in solid tumors: initial findings and future prospective

(2014) Loretta Gammaitoni et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

In Vivo Image Analysis of BoHV-4-Based Vector in Mice

(2014) Valentina Franceschi et al.   PLoS One

Microenvironment, Oncoantigens, and Antitumor Vaccination: Lessons Learned from BALB-neuT Mice

(2014) Laura Conti et al.   Biomed Research International

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma

(2013) Einar Osland Vik-Mo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The noninflammatory role of high mobility group box 1/toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells

(2013) Laura Conti et al.   FASEB JOURNAL

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired long-term potentiation and long-term memory deficits in xCT-deficientsutmice

(2012) Yan Li et al.   BIOSCIENCE REPORTS

Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity

(2012) N. Ning et al.   CANCER RESEARCH

Genetic cancer vaccines: current status and perspectives

(2012) Luigi Aurisicchio et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative-stress-inducing agent paraquat

(2012) Sho Kobayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

DNA vaccination against oncoantigens

(2012) Manuela Iezzi et al.   OncoImmunology

Viral Vector-Based Therapeutic Cancer Vaccines

(2011) Cecilia Larocca et al.   CANCER JOURNAL

Co-delivery of PSA and PSMA DNA vaccines with electroporation induces potent immune responses

(2011) Bernadette Ferraro et al.   Human vaccines & immunotherapeutics

Loss of System xFormula Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

(2011) D. De Bundel et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic neurons of system xc−-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity

(2010) Ann Massie et al.   FASEB JOURNAL

Aggravation of ischemia–reperfusion-triggered acute renal failure in xCT-deficient mice

(2009) Tomohiro Shibasaki et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

(2008) R-S Chen et al.   ONCOGENE