Article
Immunology
Abhinandan Rej, Ankush Paladhi, Samrat Daripa, Debanjan Sarkar, Sankar Bhattacharyya, Indrani Mondal, Sumit Kumar Hira
Summary: In clinical practice, efforts are being made to find suitable drug combinations that can enhance anticancer activity while minimizing side effects. In this study, the combination of doxorubicin and the TGF beta RI inhibitor galunisertib was found to be effective in treating aggressive B-cell non-Hodgkin lymphoma. The combination treatment sensitized B-NHL cells to doxorubicin and increased apoptosis. It also upregulated certain signaling pathways and resulted in reduced tumor growth and improved survival.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Kim A. Reiss, Max M. Wattenberg, Nevena Damjanov, Elizabeth Prechtel Dunphy, Mona Jacobs-Small, M. Judy Lubas, James Robinson, Lisa Dicicco, Luis Garcia-Marcano, Michael A. Giannone, Thomas B. Karasic, Emma E. Furth, Erica L. Carpenter, Andrzej P. Wojcieszynski, Robert H. Vonderheide, Gregory L. Beatty, Edgar Ben-Josef
Summary: The combination therapy of oral TGF beta inhibitor galunisertib with SBRT showed tolerability and antitumor activity in patients with advanced HCC. Changes in immune cell activity associated with the treatment could help distinguish between progressors and nonprogressors.
MOLECULAR CANCER THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Ha-Yeon Song, Fengjia Chen, Hae Ran Park, Jeong Moo Han, Hyun Jung Ji, Eui-Baek Byun, Yeongkag Kwon, Min-Kyu Kim, Ki Bum Ahn, Ho Seong Seo
Summary: Low-dose radiation therapy (LDRT) can effectively reduce the severity of coronavirus disease (COVID-19) and other cases of viral pneumonia. In this study, the molecular mechanism underlying immunological alterations in influenza pneumonia after LDRT was investigated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Review
Medicine, Research & Experimental
Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K. Mainigi
Summary: Atrial fibrillation is a common clinically significant arrhythmia with four fundamental pathophysiological mechanisms, with TGF-beta playing a key role. Studies have shown that TGF-beta 1 is involved in the development and propagation of atrial fibrillation.
Review
Cell Biology
Meng-Yan Wang, Wen-Juan Liu, Le-Yi Wu, Gang Wang, Cheng-Lin Zhang, Jie Liu
Summary: This article provides a comprehensive review of the research progress in TGF-beta 2, highlighting its role in various biological processes and its association with diseases related to dysregulation of its signaling.
Review
Biochemistry & Molecular Biology
Jinwook Chung, Md Nazmul Huda, Yoonhwa Shin, Sunhee Han, Salima Akter, Insug Kang, Joohun Ha, Wonchae Choe, Tae Gyu Choi, Sung Soo Kim
Summary: The interaction between reactive oxygen species (ROS) and transforming growth factor-beta (TGF-beta) signaling pathway plays a critical role in tumor development and progression. While ROS can influence TGF-beta signaling, the TGF-beta pathway can regulate ROS production, leading to a complex relationship between the two in cancer cells. Understanding this crosstalk may provide new insights and potential approaches in cancer biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xuanyan Cai, Huiyan Zha, Zhaoxu Yang, Yiwen Du, Xiaoyang Dai, Bo Yang, Jiajia Wang, Qiaojun He, Qinjie Weng
Summary: In this study, the relationship between TGF-beta 1 polymorphisms and susceptibility to chronic liver disease (CLD) was systematically analyzed using 35 eligible studies. The findings indicate that certain TGF-beta 1 gene variations are associated with an increased risk of CLD. Additionally, TGF-beta 1 gene expression is significantly elevated in CLD patients, and a TGF-beta 1 codon 263 variant may affect the secretion of TGF-beta 1 by altering its dimerization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beatriz Ballester, Javier Milara, Paula Montero, Julio Cortijo
Summary: The study reveals the overexpression of MUC16 in lung tissue of IPF patients and its collaboration with the TGF-beta 1 pathway to induce fibrotic processes. Repression of MUC16 expression can inhibit fibrotic processes, suggesting that targeting MUC16 may be a potential drug target for human IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Dieuwke L. Marvin, Vivian M. Spaans, Cor D. De Kroon, Roderick C. Slieker, Maryam Khelil, Peter Ten Dijke, Laila Ritsma, Ekaterina S. Jordanova
Summary: Cervical cancer is the fourth most common cancer in women worldwide, with adenocarcinoma patients having a worse prognosis. The tumor suppressor function of TGF-beta is lost in tumor cells. Analysis of RNA-seq data showed that TGF-beta plays different roles in squamous cell carcinoma and adenocarcinoma. In adenocarcinoma patients, low expression of T beta R2 and SMAD4 was associated with worse survival, while high expression of PAI-1 and alpha v beta 6 was also correlated with worse survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Qinsheng Lu, Dingqian Sun, Sourima Biswas Shivhare, Huomei Hou, Judith N. Bulmer, Barbara A. Innes, Dharani K. Hapangama, Gendie E. Lash
Summary: Appropriate growth and development of the endometrium is crucial for a woman's quality of life and reproductive health, while conditions like heavy menstrual bleeding and recurrent pregnancy loss significantly impact women's quality of life and healthcare systems. TGF beta 1 plays a key role in regulating endometrial vascular maturation and could be a potential therapeutic target for women with HMB and/or RPL.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Jay Zhu, Stoyan Angelov, Ilkay Alp Yildirim, Hao Wei, Jie Hong Hu, Mark W. Majesky, Frank Brozovich, Francis Kim, David A. Dichek
Summary: Loss-of-function variants in the TGF-beta signaling pathway can lead to endothelial dysfunction and aortic hypercontractility, potentially contributing to the development of aortic aneurysms.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Oncology
Xinhua Song, Xianqiong Liu, Haichuan Wang, Jingxiao Wang, Yu Qiao, Antonio Cigliano, Kirsten Utpatel, Silvia Ribback, Maria G. Pilo, Marina Serra, John D. Gordan, Li Che, Shanshan Zhang, Antonio Cossu, Alberto Porcu, Rosa M. Pascale, Frank Dombrowski, Hongbo Hu, Diego F. Calvisi, Matthias Evert, Xin Chen
CLINICAL CANCER RESEARCH
(2019)
Article
Cell Biology
Pan Wang, Xinhua Song, Kirsten Utpatel, Runze Shang, Yoon Mee Yang, Meng Xu, Jie Zhang, Li Che, John Gordan, Antonio Cigliano, Ekihiro Seki, Matthias Evert, Diego F. Calvisi, Xiaosong Hu, Xin Chen
CELL DEATH & DISEASE
(2019)
Article
Gastroenterology & Hepatology
Li Che, Wenna Chi, Yu Qiao, Jie Zhang, Xinhua Song, Ye Liu, Lei Li, Jiaoyuan Jia, Maria G. Pilo, Jingxiao Wang, Antonio Cigliano, Zhilong Ma, Wenhua Kuang, Zefang Tang, Zemin Zhang, Guanghou Shui, Silvia Ribback, Frank Dombrowski, Matthias Evert, Rosa Maria Pascale, Carla Cossu, Giovanni Mario Pes, Timothy F. Osborne, Diego F. Calvisi, Xin Chen, Ligong Chen
Article
Genetics & Heredity
Mara Sannai, Valentina Doneddu, Veda Giri, Steven Seeholzer, Emmanuelle Nicolas, Shu-Chin Yip, Maria Rosaria Bassi, Pietro Mancuso, Salvatore Cortellino, Antonio Cigliano, Rebecca Lurie, Hua Ding, Jonathan Chernoff, Robert W. Sobol, Timothy J. Yen, Luigi Bagella, Alfonso Bellacosa
Article
Biochemistry & Molecular Biology
Serena Mancarella, Grazia Serino, Francesco Dituri, Antonio Cigliano, Silvia Ribback, Jingxiao Wang, Xin Chen, Diego F. Calvisi, Gianluigi Giannelli
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Medicine, General & Internal
Antonio Cigliano, Maria Giulia Pilo, Marta Mela, Silvia Ribback, Frank Dombrowski, Giovanni Mario Pes, Antonio Cossu, Matthias Evert, Diego Francesco Calvisi, Kirsten Utpatel
MEDICINA-LITHUANIA
(2020)
Correction
Oncology
Maria Principia Scavo, Antonio Cigliano, Nicoletta Depalo, Elisabetta Fanizza, Maria Grazia Bianco, Nunzio Denora, Valentino Laquintana, Maria Lucia Curri, Dionigi Lorusso, Claudio Lotesoriere, Alba Panarese, Gianluigi Giannelli
JOURNAL OF ONCOLOGY
(2020)
Article
Pathology
Shu Zhang, Jie Zhang, Katja Evert, Xiaolei Li, Pin Liu, Andras Kiss, Zsuzsa Schaff, Cindy Ament, Yi Zhang, Monica Serra, Matthias Evert, Nianyong Chen, Feng Xu, Xin Chen, Junyan Tao, Diego F. Calvisi, Antonio Cigliano
AMERICAN JOURNAL OF PATHOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Christoph Metzendorf, Katharina Wineberger, Jenny Rausch, Antonio Cigliano, Kristin Peters, Baodong Sun, Daniela Mennerich, Thomas Kietzmann, Diego F. Calvisi, Frank Dombrowski, Silvia Ribback
Review
Gastroenterology & Hepatology
Antonio Cigliano, Xin Chen, Diego F. Calvisi
Summary: Cholangiocarcinoma (CCA) is an aggressive cancer type with poor prognosis, and effective therapies are still lacking. High-throughput approaches have provided better understanding of the molecular landscape of each CCA subtype, identifying promising candidates for targeted therapies. Advancements towards precision medicine in CCA management require improved clinical trial design.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Haichuan Wang, Shanshan Zhang, Yi Zhang, Jiaoyuan Jia, Jingxiao Wang, Xianqiong Liu, Jie Zhang, Xinhua Song, Silvia Ribback, Antonio Cigliano, Matthias Evert, Bingyong Liang, Hong Wu, Diego F. Calvisi, Yong Zeng, Xin Chen
Summary: TAZ is identified as a pivotal player at the crossroad between the c-MYC and Hippo pathways in HCC, playing a critical role in c-MYC-dependent hepatocarcinogenesis and potentially being targeted for the treatment of c-MYC-driven hepatocellular carcinoma patients.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sara M. Steinmann, Anabel Sanchez-Martin, Elisabeth Tanzer, Antonio Cigliano, Giovanni M. Pes, Maria M. Simile, Laurent Desaubry, Jose J. G. Marin, Matthias Evert, Diego F. Calvisi
Summary: Hepatocellular carcinoma (HCC) is a deadly primary liver tumor with limited therapeutic options in advanced stages. This study investigates the role of eukaryotic initiation factor 4A1 (eIF4A1) in HCC and suggests the potential usefulness of pharmacological combinations of eIF4A and mTOR inhibitors in treating this aggressive tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Runze Shang, Xinhua Song, Pan Wang, Yi Zhou, Xinjun Lu, Jingxiao Wang, Meng Xu, Xinyan Chen, Kirsten Utpatel, Li Che, Binyong Liang, Antonio Cigliano, Matthias Evert, Diego F. Calvisi, Xin Chen
Summary: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with limited treatment options. Cabozantinib, an orally bioavailable multikinase inhibitor approved by the FDA for HCC patients, targets c-MET/ERK/p21/PKM2 cascade and VEGFR2-induced angiogenesis, and combination therapies with mTOR inhibitors may be effective against human HCC.
Article
Gastroenterology & Hepatology
Haichuan Wang, Jingxiao Wang, Shanshan Zhang, Jiaoyuan Jia, Xianqiong Liu, Jie Zhang, Pan Wang, Xinhua Song, Li Che, Ke Liu, Silvia Ribback, Antonio Cigliano, Matthias Evert, Hong Wu, Diego F. Calvisi, Yong Zeng, Xin Chen
Summary: YAP and TAZ play overlapping and distinct roles in hepatocarcinogenesis. HCCs may exhibit unique activation of either YAP or TAZ, thus relying on either YAP or TAZ for their growth.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiaoyuan Jia, Li Che, Antonio Cigliano, Xue Wang, Graziella Peitta, Junyan Tao, Sheng Zhong, Silvia Ribback, Matthias Evert, Xin Chen, Diego F. Calvisi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)