标题
Role of Nrf2 in Oxidative Stress and Toxicity
作者
关键词
-
出版物
Annual Review of Pharmacology and Toxicology
Volume 53, Issue 1, Pages 401-426
出版商
Annual Reviews
发表日期
2013-01-09
DOI
10.1146/annurev-pharmtox-011112-140320
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- Updates on “Endoplasmic Reticulum Redox”
- (2011) Christian Appenzeller-Herzog ANTIOXIDANTS & REDOX SIGNALING
- DJ-1 regulation of mitochondrial function and autophagy through oxidative stress
- (2011) Melissa K. McCoy et al. Autophagy
- Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress
- (2011) Nicolas Mercado et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels
- (2011) A. A. Merchant et al. BLOOD
- Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
- (2011) Christine E. Hochmuth et al. Cell Stem Cell
- Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
- (2011) Stefan Freigang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
- (2011) Keiko Taguchi et al. GENES TO CELLS
- Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization
- (2011) Yumiko Kawai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signal Transduction by Mitochondrial Oxidants
- (2011) Toren Finkel JOURNAL OF BIOLOGICAL CHEMISTRY
- Signal transduction by reactive oxygen species
- (2011) Toren Finkel JOURNAL OF CELL BIOLOGY
- Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients
- (2011) Deepti Malhotra et al. JOURNAL OF CLINICAL INVESTIGATION
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Resveratrol Restores Nrf2 Level and Prevents Ethanol-Induced Toxic Effects in the Cerebellum of a Rodent Model of Fetal Alcohol Spectrum Disorders
- (2011) A. Kumar et al. MOLECULAR PHARMACOLOGY
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
- (2011) Pablo E. Pergola et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
- (2011) K.-i. Fujita et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interplay between redox status and inflammasome activation
- (2011) Anna Rubartelli et al. TRENDS IN IMMUNOLOGY
- Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway
- (2010) John D. Hayes et al. ANTIOXIDANTS & REDOX SIGNALING
- Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma
- (2010) G. Chevillard et al. BLOOD
- Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene
- (2010) Lisa Becks et al. BMC CANCER
- Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
- (2010) Hironori Satoh et al. CARCINOGENESIS
- Crucial Role of Nrf3 in Smooth Muscle Cell Differentiation From Stem Cells
- (2010) Anna Elena Pepe et al. CIRCULATION RESEARCH
- Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
- (2010) Marcus J. Calkins et al. EXPERIMENTAL NEUROLOGY
- Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions
- (2010) Jack van Horssen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver
- (2010) Soo Han Bae et al. HEPATOLOGY
- An Exceptionally Potent Inducer of Cytoprotective Enzymes
- (2010) Albena T. Dinkova-Kostova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
- (2010) Ashish Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ethanol-induced HO-1 and NQO1 Are Differentially Regulated by HIF-1α and Nrf2 to Attenuate Inflammatory Cytokine Expression
- (2010) Samantha M. Yeligar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1
- (2010) K. Taguchi et al. MOLECULAR AND CELLULAR BIOLOGY
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- (2010) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Metabolic oxidation regulates embryonic stem cell differentiation
- (2010) Oscar Yanes et al. Nature Chemical Biology
- Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
- (2010) Deepti Malhotra et al. NUCLEIC ACIDS RESEARCH
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
- (2010) M. McMahon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
- (2010) T. Ogura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Transcriptome of Nrf2−/− Mice Provides Evidence for Impaired Cell Cycle Progression in the Development of Cigarette Smoke–Induced Emphysematous Changes
- (2010) Stephan Gebel et al. TOXICOLOGICAL SCIENCES
- The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2
- (2010) Jonathan Maher et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver
- (2010) Curtis D. Klaassen et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Regulation of autophagy by ROS: physiology and pathology
- (2010) Ruth Scherz-Shouval et al. TRENDS IN BIOCHEMICAL SCIENCES
- Deletion ofKeap1in the Lung Attenuates Acute Cigarette Smoke–Induced Oxidative Stress and Inflammation
- (2009) David J. Blake et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Nrf2: friend or foe for chemoprevention?
- (2009) T. W. Kensler et al. CARCINOGENESIS
- Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
- (2009) Yoo Ri Kim et al. JOURNAL OF PATHOLOGY
- Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2
- (2009) X. He et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
- (2009) Weimin Chen et al. MOLECULAR CELL
- NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation
- (2009) X. He et al. MOLECULAR PHARMACOLOGY
- Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
- (2009) Edward Owusu-Ansah et al. NATURE
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
- (2009) Rongbin Zhou et al. NATURE IMMUNOLOGY
- Transcriptional responses to oxidative stress: Pathological and toxicological implications
- (2009) Qiang Ma PHARMACOLOGY & THERAPEUTICS
- Cigarette Smoking Blocks the Protective Expression of Nrf2/ARE Pathway in Peripheral Mononuclear Cells of Young Heavy Smokers Favouring Inflammation
- (2009) Ulisse Garbin et al. PLoS One
- Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
- (2009) Pei-Chun Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxidative Stress and Alcoholic Liver Disease
- (2009) Defeng Wu et al. SEMINARS IN LIVER DISEASE
- Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice
- (2009) Scott A. Reisman et al. TOXICOLOGICAL SCIENCES
- The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis
- (2009) Delinda A. Johnson et al. TOXICOLOGICAL SCIENCES
- CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes
- (2009) Scott A. Reisman et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
- (2009) Madhurima Biswas et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1
- (2008) Deepti Malhotra et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Mouse Embryos Exposed to Ethanol in vivo: Implications for the Prevention of Fetal Alcohol Spectrum Disorders
- (2008) Jian Dong et al. ANTIOXIDANTS & REDOX SIGNALING
- Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
- (2008) Rui Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis
- (2008) Wenge Li et al. BIOCHEMICAL PHARMACOLOGY
- Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer
- (2008) T. O. Khor et al. Cancer Prevention Research
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- Xenobiotic-Activated Receptors: From Transcription to Drug Metabolism to Disease
- (2008) Qiang Ma CHEMICAL RESEARCH IN TOXICOLOGY
- Activation of Nrf2 in Defense against Cadmium-Induced Oxidative Stress†
- (2008) Xiaoqing He et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1
- (2008) Claude A. Piantadosi et al. CIRCULATION RESEARCH
- Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila
- (2008) Gerasimos P. Sykiotis et al. DEVELOPMENTAL CELL
- PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
- (2008) Shih-Ching Lo et al. EXPERIMENTAL CELL RESEARCH
- Redox-based regulation of signal transduction: Principles, pitfalls, and promises
- (2008) Yvonne M.W. Janssen-Heininger et al. FREE RADICAL BIOLOGY AND MEDICINE
- Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer
- (2008) Tatsuhiro Shibata et al. GASTROENTEROLOGY
- Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
- (2008) Patrick L. Apopa et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes
- (2008) Xiaoqing He et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis
- (2008) M. R. Vargas et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
- (2008) Eunsung Junn et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity
- (2008) T. Yamamoto et al. MOLECULAR AND CELLULAR BIOLOGY
- The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds
- (2008) M. Kobayashi et al. MOLECULAR AND CELLULAR BIOLOGY
- Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling
- (2008) N M Reddy et al. ONCOGENE
- Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function
- (2008) Richard C. Scarpulla PHYSIOLOGICAL REVIEWS
- Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
- (2008) T. E. Sussan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
- (2008) T. Shibata et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
- (2008) C. Dostert et al. SCIENCE
- Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema
- (2008) D Goven et al. THORAX
- Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung
- (2007) Steven G. Kelsen et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2
- (2007) Dianne M. Walters et al. ANTIOXIDANTS & REDOX SIGNALING
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started